Clinical subtypes and prognosis in breast cancer according to parity: a nationwide study in Korean Breast Cancer Society

Park, Sung Min; Moon, Byung In; Oh, Se Jeong; Lee, Han‐Byoel; Seong, Min Ki; Lee, Seok-Won; Byun, Kyung Do; Jung, Seung Pil; Bae, Soo Youn

doi:10.1007/s10549-018-5032-3

Cited by 6 publications

(6 citation statements)

References 36 publications

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“…Previous studies have suggested that parity is correlated with either favorable or unfavorable breast cancer prognoses (2,15,16). In particular, high parity has been associated with poor outcomes for TNBC and luminal subtype tumors (7,9,13). The discrepancies between studies may be due to heterogenous patient material, varying subtype definitions or the dependence on retrospective registry-based studies.…”

Section: Discussionmentioning

confidence: 99%

“…Previous findings have also suggested that pregnancyrelated effects on breast cancer incidence and prognoses may vary among breast cancer subtypes (7)(8)(9). The five intrinsic breast cancer subtypes, which are classed according to their immunohistochemical (IHC) surrogates using the European Society for Medical Oncology (ESMO) 2015 Early Breast Cancer Clinical Practice Guidelines, differ in terms of both their molecular constitutions and patient prognoses (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

“…Although evidence about the prognostic role of patient reproductive history is still emerging, it has become clear that reproduction-related risk factors differ among the breast cancer subtypes ( 13 – 15 ). In particular, registry- and population-based studies have suggested that high parity is an adverse prognostic factor in luminal subtypes and in triple-negative breast cancer (TNBC); however, breast cancer subtype definition has varied, and there have been few prospective studies ( 7 , 9 , 13 , 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

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High Parity Predicts Poor Outcomes in Patients With Luminal B-Like (HER2 Negative) Early Breast Cancer: A Prospective Finnish Single-Center Study

et al. 2020

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While breast cancer prognoses are generally good, different molecular subtypes are known to have varying outcomes. Previous studies using breast cancer registries have suggested that high parity may be an adverse prognostic factor in luminal breast cancer, but breast cancer subtype definitions have varied and there have been few prospective studies. We therefore collected prospective data from patients diagnosed with early breast cancer at a single institution and followed them for a median of 8.5 years. All patients (N = 594) were treated according to Finnish national guidelines using modern treatment modalities in a Finnish university hospital. Clinicopathological surrogates of the intrinsic breast cancer subtypes were updated to match European Society for Medical Oncology 2015 Early Breast Cancer Clinical Practice Guidelines. The overall 10-year breast cancer-specific survival (BCSS) was 91.4%, with the longest 10-year BCSS observed in luminal Alike cancers (97.9%) and the worst in luminal B-like (HER2 positive) cancers (80.6%). Parity of ≥ 5 deliveries was also associated with poor BCSS (univariate P = 0.0020). However, when the subtypes were assessed separately in a multivariate analysis that included tumor size and nodal status, high parity remained significant only in luminal B-like (HER2 negative) cancers (HR = 2.63; 95% confidence interval = 1.04-6.62; P = 0.040). Our results suggest excellent overall 10-year BCSS but indicate that high parity is an adverse prognostic factor in luminal B-like (HER2 negative) breast cancers.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High Parity Predicts Poor Outcomes in Patients With Luminal B-Like (HER2 Negative) Early Breast Cancer: A Prospective Finnish Single-Center Study

et al. 2020

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“…Nationwide breast cancer data have been analyzed and reported by the KBCS since 1996 for the evaluation of chronological changes in Korean breast cancer patients [ 13 ]. Thirty-eight of the 41 medical schools in Korea and more than 100 hospitals, including 74 university hospitals, 24 general hospitals, and 6 private breast clinics, voluntarily participated in the program, and the database was established online [ 14 ]. The database provides clinicopathological factors, such as age; sex; type of surgery; breast cancer stage (according to the 8th American Joint Committee on Cancer classification); family history; parity; age of menarche; histology; presence of the biological markers estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2); methods of treatment; types of chemotherapy; and date and cause of death [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

Low incidence of lymph node metastasis in patients with microinvasive breast cancer: a Korean nationwide study

Paik

Lee

et al. 2022

Ann Surg Treat Res

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Purpose Microinvasive breast cancer (MIBC) is an invasive carcinoma with a tumor dimension not exceeding 1 mm. Owing to its low incidence, the rate of axillary node metastasis and its management are not well established. The aim of this study was to assess the incidence of lymph node metastasis (LNM) and identify variables associated with LNM, as well as to evaluate the need for axillary staging in MIBC patients by analyzing nationwide data. Methods The Korean Breast Cancer Society registry was searched to identify MIBC patients diagnosed between January 1996 and April 2020. Patients without neoadjuvant chemotherapy experiences, systemic metastasis, and missing or discordant data were eligible for the analysis. The incidence rate of LNM was determined, and variables associated with LNM were identified by multivariable regression analysis. Results Of 2,427 MIBC patients identified, 98 (4.0%) had LNM and 12 (0.5%) had N2/3 disease. Type of breast operation (odds ratio [OR], 2.093; 95% confidence interval [CI], 1.332–3.290; P = 0.001), age (OR, 2.091; 95% CI, 1.326–3.298; P = 0.002), hormone receptor status (OR, 2.220; 95% CI, 1.372–3.594; P = 0.001), and lymphovascular invasion (OR, 11.143; 95% CI, 6.354–19.540; P < 0.001) were significantly related to LNM. Conclusion The incidence of LNM in MIBC patients was only 4.0% in our study, suggesting that de-escalation of axillary surgical interventions could be carefully considered. The indications for axillary staging should be individualized considering tumor volume, age, hormone receptor status, and lymphovascular invasion to improve the quality of life of MIBC survivors.

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“…ORC technology has a broad application prospect because it has advantages of high flexibility, high safety, good thermal performance, and low maintenance requirements. [ 14 ] In addition, the organic working fluid has a lower boiling point than water, enabling the recovery of energy from a low‐temperature heat source. [ 15 ] For example, Galloni et al [ 16 ] recovered waste heat from a low‐temperature heat source of 75–95°C to generate a net power ( W net ) of 1.2 kW using the ORC method, and Wang et al [ 17 ] recovered heat from an exhaust gas of 130°C using the ORC method, and the enthalpy efficiency of the ORC system reached a high value of 13.98%.…”

Section: Introductionmentioning

confidence: 99%

Heat recovery from hydrothermal carbonization slurry product by coupling processes of flash and organic Rankine cycle: Thermodynamic analysis

et al. 2021

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Hydrothermal carbonization (HTC) is a promising and effective technology for upgrading the fuel quality of high‐moisture organic wastes. However, a large amount of energy is required to heat the feedstock to high temperature for HTC. Therefore, the maximum waste heat should be recovered to increase the energy efficiency of the HTC process. In this work, a flash‐organic Rankine cycle (FSPG‐ORC) system was coupled after HTC to recover the heat contained in the HTC slurry product. Various operating factors including the flashing temperature, the HTC temperature, the solid‐water ratio (S/W) of the feedstock, and the organic working fluids in the ORC section were studied to obtain their influences on thermodynamic performance of the coupled system. Results indicated that the net power (Wnet) of the FSPG‐ORC system increased from 185.64 to 774.30 kW through the increase of the HTC temperature from 160 to 280°C. In addition, the Wnet and exergy efficiency of the FSPG‐ORC system also increased with increasing the flashing temperature of HTC slurry product. The coupled FSPG‐ORC system converted waste heat to electric energy and increased the energy efficiency of the HTC process.

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Clinical subtypes and prognosis in breast cancer according to parity: a nationwide study in Korean Breast Cancer Society

Cited by 6 publications

References 36 publications

High Parity Predicts Poor Outcomes in Patients With Luminal B-Like (HER2 Negative) Early Breast Cancer: A Prospective Finnish Single-Center Study

High Parity Predicts Poor Outcomes in Patients With Luminal B-Like (HER2 Negative) Early Breast Cancer: A Prospective Finnish Single-Center Study

Low incidence of lymph node metastasis in patients with microinvasive breast cancer: a Korean nationwide study

Heat recovery from hydrothermal carbonization slurry product by coupling processes of flash and organic Rankine cycle: Thermodynamic analysis

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