Clinical Study on the Efficacy of Fluvoxamine for Psychological Distress in Gynecologic Cancer Patients

Abstract

The present findings suggest that fluvoxamine is useful for alleviating psychological distress, including adjustment disorder and major depression, in gynecologic cancer patients. Management of psychological distress after diagnosis of cancer is important.

A systematic review of pharmacologic treatment efficacy for depression in older patients with cancer

“…After treatment with fluvoxamine in patients with depression or adjustment disorder, HADs scores were significantly reduced at 6 weeks post-treatment. In the depression group, vitality and emotional health was also improved in this cohort as evaluated by the SF-36 scale (n ​= ​10) ( Suzuki et al., 2011 ).…”

“…( Schillani et al., 2008 ) – – – 11.3 ​± ​0.9 6.7 ​± ​1.0 0.003 6.7 ​± ​1.3 3.5 ​± ​0.9 2 Suzuki et al. ( Suzuki et al., 2011 ) – – – Total HADs MDD: 25 (21–28) ADDM: 15 (13–17) Reduced <0.05 Not specified Reduced <0.01 8 Torta et al. ( Torta et al., 2011 ) 32.3 ​± ​8.9 14.5 ​± ​10.8 <0.05 14.4 ​± ​3.8 7.2 ​± ​4.6 <0.05 13.2 ​± ​4.5 6.6 ​± ​4.5 <0.05 12 Torta et al.…”

“…( Rodriguez Vega et al., 2011 ) 2011 RCT Escitalopram SSRI Y 33 (E only) 56 ​± ​10.8 (E only) 24 Suzuki et al. ( Suzuki et al., 2011 ) 2011 PNRT Fluvoxamine SSRI MDD, ADDM 10 53 (33–66) 8 Capozzo et al. ( Capozzo et al., 2009 ) 2009 PNRT Citalopram SSRI Y 21 71.1 ​± ​12.1 2 Schillani et al.…”

“…( Rodriguez Vega et al., 2011 ) 3 Breast (48), Colorectal (15), Lung (9) 72 Suzuki et al. ( Suzuki et al., 2011 ) 3 Cervical (2), Ovarian (3), Endometrial (5) 10 Capozzo et al. ( Capozzo et al., 2009 ) 11 Colon/Rectum (4), Pancreas (3), Lung (2), Prostate (2), Breast (2), Liver (2), Esophagus (2), Brain (1), Stomach (1), Ethmoid bone (1), Hematologic (1) 21 Schillani et al.…”

Update on Research-Based Interventions for Anxiety in Patients With Cancer

“…al., 2008). Researchers evaluated antidepressants for effect on depression, anxiety, and sleep (Cankurtaran et al, 2008;Suzuki et al, 2011;Torta, Leombruni, Borio, & Castelli, 2011), revealing significant improvement in anxiety with mirtazapine, fluvoxamine, or duloxetine. The studies were limited by nonrandomized design and small samples.…”