Clinical Study on Selective Enhancement of Drug Delivery by Angiotensin II in Cancer Chemotherapy

Sato, Haruhiko; Sato, Ko; Satô, Yukio; Mimata, Yoshikuni; Asamura, M; Kanamuru, R.; Wakui, A; Suzuki, Maroh

doi:10.1007/978-94-009-8925-2_75

Cited by 10 publications

(11 citation statements)

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“…Clinical studies on induced hypertension chemotherapy, based on basic knowledge dealing with characteristics of tumor vessels have been underway since 1978 by A Wakui, H Sato and others of the Department of Clinical Cancer Chemotherapy in our institute (14)(15)(16). Several other institutes and hospitals in Japan have also been interested in examining induced hypertension chemotherapy on tumors.…”

Section: Clinical Application Of Angiotensin-induced Hypertension Chementioning

confidence: 99%

“…In this review, we describe some aspects of tumor vessels and their functional characteristics in the microcirculation of tumors, particularly with regard to selective enhancement of tumor blood flow (4--13). We also briefly outline a new approach (8,(14)(15)(16) to cancer chemotherapy, i.e., induced hypertension chemotherapy with angiotensin II. This approach is based on the finding that delivery to tumor tissue of systemically administered anticancer drugs can be selectively enhanced without any increase in drug delivery to normal tissues.…”

Section: Introductionmentioning

confidence: 99%

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Functional characterization of the microcirculation in tumors

et al. 1984

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This review describes some aspects of tumor vessels and the influence of vasoactive agents on tumor blood flow, particularly the characteristic microcirculation of tumors with regard to its selective increase in blood flow. Elevation of blood pressure by infusion of angiotensin II produced a severalfold increase in tumor blood flow. The increase was selective and specific to the tumor vessels as long as the mean arterial blood pressure was kept under 150 mm Hg. Pressure elevation by angiotensin II also selectively increased tumor oxygen tension and influx of lymph flow from the primary transplanted lesion to the lymph node metastatic lesion. Newly devised techniques for analyzing microhemodynamics of tumor vessels showed that the velocity of tumor blood flow, the vascular area in tumor tissue, and the hydrostatic pressure difference between the tumor vessel and extravascular tissue were markedly enhanced. Thus, the extravasation of material into tumor tissues can be increased by the enhancement of blood flow. This demonstration allowed the development of a new approach to cancer chemotherapy, in which the delivery to tumor tissue of systemically administered anticancer drugs can be selectively enhanced.

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Section: Clinical Application Of Angiotensin-induced Hypertension Chementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Functional characterization of the microcirculation in tumors

et al. 1984

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“…5) The solutions of (1) were identified with the points of universal Grassmannian by Sato and known as the τ functions [11].…”

Section: Introductionmentioning

confidence: 99%

Singularity Confinement and Projective Resolution of Triangulated Category

Saito,

Yumibayashi,

Wakimoto

2013

Preprint

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“…In 2 we give an expression or the r unctions of the KP hierarchy by means of the Clifford operators used in [10]. In 3 we give the explicit orms o Hirota's bilinear equations or them using a transformation introduced in [8]. In 4, as a corollary o the operator expression given in 2, we show that the characters o the general linear group are r unctions 2or the KP hierarchy; that is one o the astonishing results o M. and Y. Sato [9].…”

mentioning

confidence: 99%

“…In [8], M. Sato and Y. Sato listed the bilinear equations satisfied by r(x) up to degree 11, and conjectured that the number o bilinear equations o degree n is equal to p(n-1), where p(n) is the partition unction; p(n)={(n, ..., n)]n integer s.t. lnn n and In 3 we propose a refined version o their conjecture by giving explicit forms of bilinear equations or every degree.…”

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confidence: 99%