Clinical study of XiangShaLiuJunZi decoction combined with S-1 as maintenance therapy for stage III or IV gastric carcinoma and colorectal carcinoma

Hong, Xiao-Cui; Liang, Qiong; Luo, Xing-Bo; Hu, Kehui; Yang, Huiling; Ou, Wen‐Ting; Zhang, Huijie

doi:10.1097/md.0000000000020081

Cited by 12 publications

(6 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, “preventive treatment” is one of the core concepts of traditional Chinese medicine. In clinical practice, many traditional prescriptions have been applied, such as the Sijunzi decoction ( Zhong et al, 1997 ; Cai et al, 2008 ), Xiangshaliujunzi decoction ( Lv et al, 2017 ; Hong et al, 2020 ), etc. Among these decoctions, Codonopsis pilosula (Franch.)…”

Section: Introductionmentioning

confidence: 99%

Proteomics and Metabolomics Unveil Codonopsis pilosula (Franch.) Nannf. Ameliorates Gastric Precancerous Lesions via Regulating Energy Metabolism

Jin

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Objective: This study aimed to systematically evaluate the efficacy of Codonopsis pilosula (Franch.) Nannf. (Codonopsis Radix, CR) and reveal the mechanism of its effects on suppressing Gastric Precancerous Lesions.Methods: First, we established the GPL rat model which was induced by N-methyl-N′-nitro-N-nitrosoguanidine, a disordered diet, and 40% ethanol. The CR’s anti-Gastric Precancerous Lesions effect was comprehensively evaluated by body weight, pathological section, and serum biochemical indexes. Then, quantitative proteomics and metabolomics were conducted to unveil the disturbed protein-network and pharmacodynamic mechanism. Furthermore, serum pharmacology was employed to confirm that CR’s anti-gastritis and anti-cancer phenotype in cell models.Results: In animal models, CR had been shown to control inflammation and ameliorate Gastric Precancerous Lesions. Considering the combination of proteomics and metabolomics, we found that CR could significantly reverse the biological pathways related to energy metabolism which were disturbed by the Gastric Precancerous Lesions model. Furthermore, the results of serum pharmacology indicated that the Codonopsis Radix containing serum could ameliorate gastritis injury and selectively inhibit the proliferation of gastric cancer cells rather than normal cells, which was closely related to ATP production in the above mentioned cells.Conclusion: In summary, CR exerted anti-Gastric Precancerous Lesions effects by ameliorating gastritis injury and selectively inhibiting the proliferation of gastric cancer cells rather than normal cells. Proteomics and metabolomics unveiled that its efficacy was closely related to its regulation of the energy-metabolism pathway. This research not only provided new ideas for exploring the mechanism of complex systems such as Chinese herbals but also benefited the treatment strategy of Gastric Precancerous Lesions via regulating energy metabolism.

show abstract

Section: Introductionmentioning

confidence: 99%

Proteomics and Metabolomics Unveil Codonopsis pilosula (Franch.) Nannf. Ameliorates Gastric Precancerous Lesions via Regulating Energy Metabolism

Jin

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…It has been reported that traditional Chinese medicine (TCM) combined with chemotherapy can improve CRC treatment, through reducing postoperative ileus and urinary, improving the tolerance of patients and the complications and resistance of chemotherapy, remodeling the gut microbiota and the tumor microenvironment, suppressing thymidylate synthase, and preventing cancer recurrence and metastasis, etc. ( Tan et al, 2008 ; Ye et al, 2015 ; Liu et al, 2017a ; Sui et al, 2017 ; Liu et al, 2018a ; Zhang et al, 2018 ; Lv et al, 2019 ; Hong et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effect and Mechanism of Bushen-Jianpi-Jiedu Decoction Combined with Chemotherapeutic Drugs on Postoperative Colorectal Cancer

et al. 2021

View full text Add to dashboard Cite

There is a lack of effective therapeutic drugs in patients with postoperative colorectal cancer (PCRC). This study aimed to investigate the therapeutic effect and mechanisms of Bushen-Jianpi-Jiedu decoction (BSJPJDD) combined with chemotherapeutic drugs (oxaliplatin) on PCRC with liver and kidney yin deficiency and spleen deficiency syndrome (LKYD-SDS) through the therapeutic evaluation of clinical therapy and the integrative analysis of network pharmacology, RNA-seq and label-free data, and experiment verification in vitro. In clinical therapy, the median progression-free survival (PFS) and Karnofsky performance score (KPS) were increased in PCRC patients by the aqueous extract of BSJPJDD combined with oxaliplatin treatment for three months, compared to oxaliplatin alone (p < 0.05). The integrative analysis showed that 559 differentially expressed genes (DEGs) and 11 differentially expressed proteins (DEPs) were regulated by BSJPJDD, among which seven bioactive compounds through 39 potential targets were involved in the regulation of multiple signaling pathways including MAPK, PI3K-Akt, and HIF-1, etc. In the experimental verification, an ELISA assay showed that plasma ZEB2, CAT, and KRT78 were decreased, and IL-1Α, CD5L, FBLN5, EGF, and KRT78 were increased in comparison to the above (p < 0.05). Furthermore, the SW620 cell viability was inhibited and the expressions of MAPK and the p-ERK/ERK ratio were significantly downregulated by the aqueous extract of BSJPJDD combined with oxaliplatin treatment, compared with oxaliplatin treatment alone (p < 0.05). These data suggested that BSJPJDD combined with oxaliplatin prolongs the survival and improves Karnofsky performance status of PCRC patients with LKYD-SDS, and may be associated with the regulation of multiple signaling pathways.

show abstract

“…[ 16 ] Modern research shows that XSLJZ can be used to treat nausea, vomiting, abdominal distension, diarrhea, and diarrhea. [ 17 , 18 ] Therefore, it is often used to treat CINV in China. The clinical effect of XSLJZ on CINV may be achieved by up-regulating the production of ghrelin, cholecystokinin and vasoactive intestinal polypeptides and increasing the levels of these neuropeptides in the circulation.…”

Section: Introductionmentioning

confidence: 99%

“…Xiang-Sha-Liu-Jun-Zi (XSLJZ) created by Yunbo Ke, a doctor of Chinese medicine in the Qing Dynasty, is a classic formula of TCM [16] . Modern research shows that XSLJZ can be used to treat nausea, vomiting, abdominal distension, diarrhea, and diarrhea [17,18] . Therefore, it is often used to treat CINV in China.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Xiang-Sha-Liu-Jun-Zi on chemotherapy-induced nausea and vomiting

Xiao

Liu

et al. 2021

Medicine

View full text Add to dashboard Cite

Background: Cancer is the main cause of death worldwide, and chemotherapy is the basic method of treating cancer. However, chemotherapy-induced nausea and vomiting (CINV) is the most common side effect of chemotherapy, and conventional antiemetics for the treatment of CINV also have side effects. At present, a large number of randomized controlled trials have shown that Xiang-Sha-Liu-Jun-Zi (XSLJZ) can effectively treat CINV, but there is no systematic review. Therefore, this systematic review aims to discuss the effectiveness of XSLJZ in the treatment of CINV. Methods: Search for relevant documents in the Chinese and English databases, and the search time is limited to March 2021. Databases include Embase, Cochrane Library, Web of Science, PubMed, China National Knowledge Infrastructure, Chongqing VIP Information Resource Integration Service Platform, Wanfang Data, Chinese Biomedical Literature, etc. We will search the international clinical trial registration platform and the Chinese clinical trial registration platform to find ongoing and unpublished clinical trials. Randomized controlled trial of the efficacy of XSLJZ in the treatment of CINV were collected. After screening the literature according to the inclusion and exclusion criteria, two researchers independently extracted the data. The effective rate of treatment is the main outcome indicator of this study. The secondary indicators of this study include the incidence of adverse reactions and the improvement rate of quality of life. RevMan 5.3.5 software was used for statistical analysis. Grades of Recommendation, Assessment, Development, and Evaluation system will be used to evaluate the quality evidence for each outcome. Results: This study will provide the latest evidence for the treatment of CINV by XSLJZ. Conclusion : To evaluate the efficacy of XSLJZ in the treatment of CINV. Unique INPLASY number: INPLASY202140079.

show abstract

Clinical study of XiangShaLiuJunZi decoction combined with S-1 as maintenance therapy for stage III or IV gastric carcinoma and colorectal carcinoma

Abstract: Supplemental Digital Content is available in the text

Cited by 12 publications

References 24 publications

Proteomics and Metabolomics Unveil Codonopsis pilosula (Franch.) Nannf. Ameliorates Gastric Precancerous Lesions via Regulating Energy Metabolism

Proteomics and Metabolomics Unveil Codonopsis pilosula (Franch.) Nannf. Ameliorates Gastric Precancerous Lesions via Regulating Energy Metabolism

Therapeutic Effect and Mechanism of Bushen-Jianpi-Jiedu Decoction Combined with Chemotherapeutic Drugs on Postoperative Colorectal Cancer

Efficacy of Xiang-Sha-Liu-Jun-Zi on chemotherapy-induced nausea and vomiting

Contact Info

Product

Resources

About