Clinical study of Presepsin and Pentraxin3 in critically ill children

Gendy, Fady M. El; El-Mekkawy, Muhammad Said; Saleh, Nagwan Y.; Habib, Mona Salah El‐din; Younis, Faten E

doi:10.1016/j.jcrc.2018.06.004

Cited by 17 publications

(14 citation statements)

References 25 publications

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“…The results of many clinical studies have indicated that Presepsin is a useful biomarker not only for early diagnosis, but also for risk stratification and prognosis prediction for sepsis in adults (26) as well as children (27). The present study shows that Presepsin was, as the case in sepsis (28), inferior to PTX3 in predicting IVIG resistance and/or CAL formation. The pathophysiology of the acute phase of Kawasaki disease is characterized by excessive activation of the innate immune system and is accompanied by an increase in inflammatory cytokines and chemokines (29).…”

Section: Discussionmentioning

confidence: 49%

Increased Pentraxin 3 Levels Correlate With IVIG Responsiveness and Coronary Artery Aneurysm Formation in Kawasaki Disease

et al. 2021

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Kawasaki disease (KD) is a febrile disease of childhood characterized by systemic vasculitis that can lead to coronary artery lesions (CAL). This was a prospective cohort study to determine the levels of the pentraxin 3 (PTX3), soluble CD24-Subtype (Presepsin) and N-terminal pro-brain natriuretic peptide (NT-pro BNP) in consecutive KD patients. From January 2013 to March 2015, all patients with KD admitted to Aichi Medical University Hospital who provided consent had their plasma saved before IVIG administration. In total, 97 cases were registered. 22 cases of incomplete KD were excluded from the outcome analysis. The total 75 cases were used for statistical analyses. A PTX3 threshold of >7.92 ng/ml provided a specificity of 88.5 %, a sensitivity of 94.4 %, and a likelihood ratio as high as 15.92 for the diagnosis of KD compared with febrile non-KD controls. Although an echocardiographic diagnosis of CAL in the early course of the disease was confirmed in 24 cases, it was not in the remaining 51 cases. Neither NT-proBNP nor Presepsin had statistical significance for the prediction of the echocardiographic CAL diagnosis. Only PTX3 was significantly predictive of the echocardiographic CAL diagnosis (p=0.01). The PTX3 level was significantly higher in the intravenous immunoglobulin (IVIG) non-responders (45.9±7.45) than in the IVIG responders (17.0 ± 1.46 ng/ml) (p< 0.001). The PTX3 level also correlated with the number of IVIG treatment courses needed to resolve fever (R² =0.64). Persistent CAL (pCAL) formation was observed in three cases; one of aneurysm only and two aneurysms with dilatations. The patients with pCAL had significantly higher PTX3 levels (85 ± 8.4 ng/ml) than patients without pCAL (22 ± 2.2 ng/ml) (p< 0.0001). In terms of pCAL prediction, the area under the curve (AUC) of receiver operating characteristic ROC curve of PTX3 was 0.99, and it was significantly greater than that of Presepsin (0.67) or NT-proBNP (0.75). PTX3 is a soluble pattern recognition molecule that acts as a main component of the innate immune system. These data suggest that PTX3 can be utilized as a definitive biomarker for the prediction of IVIG resistance and subsequent CAL formation in patients with KD.

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Section: Discussionmentioning

confidence: 49%

Increased Pentraxin 3 Levels Correlate With IVIG Responsiveness and Coronary Artery Aneurysm Formation in Kawasaki Disease

et al. 2021

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“…According to a recent meta-analysis, presepsin showed high sensitivity and diagnostic accuracy in sepsis in children compared to CRP and PCT, but its specificity was lower. There was also a significant increase in presepsin concentration in children with suspected or registered catheter-associated infection compared to healthy children in the control group [44], [45], [46].…”

Section: Specific Diagnosis Of Sepsis and Septic Shock In Childrenmentioning

confidence: 86%

“…Pentraxin 3 significantly increases in critically ill children, including those with sepsis, but there was no difference in the concentration of pentraxin 3 between critically ill children with sepsis and other diagnoses. Thus, pentraxin 3 is more of a marker of systemic inflammation than of sepsis [45].…”

Section: Sirsmentioning

confidence: 99%

Modern Diagnostics of Sepsis and Septic Shock in Children

Bulatova

Maltabarova

Zhumabayev

et al. 2020

Open Access Maced J Med Sci

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Sepsis is still one of the leading causes of child mortality worldwide, despite advances in its diagnosis and treatment. Difficulties in recognizing the transition of a localized infectious-inflammatory process to a generalized one lead to a belated diagnosis and the beginning of therapy. Meanwhile, the earlier treatment is started, the higher the patients’ chances of life. Early diagnosis of sepsis, which corresponds to modern ideas about this condition, is one of the main tasks for both scientists and practitioners. The aim of this review is to study modern recommendations for the diagnosis of sepsis and septic shock in children. The article reflects the epidemiology, etiological features, modern definitions, and methods of diagnosis of pediatric sepsis.

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“…According to a recent metaanalysis, presepsin showed high sensitivity and diagnostic accuracy in sepsis in children compared to CRP and PCT, but its specificity was lower. There was also a significant increase in presepsin concentration in children with suspected or registered catheter-associated infection compared to healthy children in the control group (45)(46)(47).…”

Section: Specific Diagnosis Of Sepsis and Septic Shock In Childrenmentioning

confidence: 87%

Section: Specific Diagnosis Of Sepsis and Septic Shock In Childrenmentioning

confidence: 99%

Modern Diagnostics of Sepsis and Septic Shock in Children

et al. 2020

View full text Add to dashboard Cite

Sepsis is still one of the leading causes of child mortality worldwide, despite advances in its diagnosis and treatment. Difficulties in recognizing the transition of a localized infectious-inflammatory process to a generalized one lead to a belated diagnosis and the beginning of therapy. Meanwhile, the earlier treatment is started, the higher the patients' chances of life. Early diagnosis of sepsis, which corresponds to modern ideas about this condition, is one of the main tasks for both scientists and practitioners. The aim of this review is to study modern recommendations for the diagnosis of sepsis and septic shock in children. The article reflects the epidemiology, etiological features, modern definitions and methods of diagnosis of pediatric sepsis.

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Clinical study of Presepsin and Pentraxin3 in critically ill children

Cited by 17 publications

References 25 publications

Increased Pentraxin 3 Levels Correlate With IVIG Responsiveness and Coronary Artery Aneurysm Formation in Kawasaki Disease

Increased Pentraxin 3 Levels Correlate With IVIG Responsiveness and Coronary Artery Aneurysm Formation in Kawasaki Disease

Modern Diagnostics of Sepsis and Septic Shock in Children

Modern Diagnostics of Sepsis and Septic Shock in Children

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