Clinical Study of Graft Materials Using Autogenous Teeth in Maxillary Sinus Augmentation

Jeong, Kyung-In; Kim, Su-Gwan; Kim, Young-Kyun; Oh, Ji‐Su; Jeong, Mi‐Ae; Park, Jin-Ju

doi:10.1097/id.0b013e3182386d74

Cited by 69 publications

(69 citation statements)

References 16 publications

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“…Among them, the emerging autogenous dentin materials were successfully used for various clinical situations including guided bone regeneration (GBR), sinus grafts, and ridge preservation [20,21]. Many studies have indicated that manipulated dentin materials can act as osteoconductive or even osteoinductive substitutes for common graft biomaterials [31].…”

Section: Discussionmentioning

confidence: 99%

“…Several recent studies have demonstrated that DDM is well-tolerated when used to fill the ridge defects, indicating promising potential for bone regeneration [13][14][15]20]. Similarly, the effectiveness of DDM as a bone substitute has already been identified in various clinical circumstances such as the alveolar bone regeneration associated with dental implants, sinus augmentation, and preservation of extraction sockets [13][14][15]21,22]. In these studies, DDM completely fulfills the criteria for a bone regeneration material, possessing osteoinductive and osteoconductive properties [23].…”

Section: Introductionmentioning

confidence: 99%

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Volumetric, Radiographic, and Histologic Analyses of Demineralized Dentin Matrix Combined with Recombinant Human Bone Morphogenetic Protein-2 for Ridge Preservation: A Prospective Randomized Controlled Trial in Comparison with Xenograft

et al. 2018

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Featured Application: Novel technology of bone regeneration.Abstract: The aim of this study was to evaluate the clinical, volumetric, radiographic, and histologic aspects of autogenous demineralized dentin matrix (DDM) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) used for ridge preservation, compared to those of deproteinized bovine bone with collagen (DBBC). Following atraumatic extraction, the socket was filled with DBBC, DDM, or rhBMP-2/DDM. Scanned images of dental casts and cone beam computed tomographs (CBCT) were superimposed for the calculation of soft and hard tissue volume alteration. Preoperative and postoperative measurements of the height and width of the alveolar ridge were compared using CBCT images. After 4 months, bone specimens were harvested for histomorphometric assessment. Loss of hard and soft tissue volume occurred at 4 months after extraction and ridge preservation in all groups. No volumetric differences were detected among the three groups before and 4 months after ridge preservation. The reduction in the horizontal width at 5 mm was higher in the DBBC compared to the DDM. Histologically, approximately 40% newly formed bone was founded in rhBMP-2/DDM group. The autogenous dentin matrix used to fill the socket was as beneficial for ridge preservation as conventional xenografts. The combination of rhBMP-2 with dentin matrix also demonstrated appreciable volumetric stability and higher new bone formation compared to DDM alone and DBBC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Volumetric, Radiographic, and Histologic Analyses of Demineralized Dentin Matrix Combined with Recombinant Human Bone Morphogenetic Protein-2 for Ridge Preservation: A Prospective Randomized Controlled Trial in Comparison with Xenograft

et al. 2018

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“…The analyses of mandibular cortical bone taken from patients, crown of autogenous tooth bone graft material, root of autogenous tooth bone graft material, irradiated mineralized allogeneic cancellous bone (ICB; Rocky Mountain Tissue Bank, Denver, CO, USA), xenograft bone (Bio-Oss), and synthetic bone MBCP (Biomatlante, Vigneux de Bretagne, France) showed that the x-ray diffraction (XRD) pattern of dentin of autogenous tooth bone graft material and allograft bone was most similar to autogenous bone, and this finding has been announced 50 . Many authors have published case reports as well as the results of clinical studies on sinus bone graft, ridge augmentation, guided bone regeneration, socket preservation or graft, and they have proven to be useful materials for hard tissue defect restoration [51][52][53][54][55][56][57][58][59] . Lee 60 performed quantitative analysis of the proliferation and differentiation of the MG-63 cell line on the bone grafting material using human tooth.…”

Section: Discussionmentioning

confidence: 99%

Bone graft material using teeth

Kim

2012

J Korean Assoc Oral Maxillofac Surg

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(J Korean Assoc Oral Maxillofac Surg 2012;38:134-8) Autogenous tooth bone graft material contains organic and inorganic components for osteoinductive and osteoconductive healing. The clinical availability and safety of this material have been confirmed by various experimental and clinical studies. In the future, allogenic and xenogenic tooth bone graft materials, ideal scaffold using teeth for stem cells and bone growth factors, and endodontic and tooth restorative material will be developed.Key words: Tooth, Bone graft material [paper submitted 2012. 4. 6 / accepted 2012. 4. 6] and its osteoconduction capacity is low. Moreover, it cannot be degraded by macrophage. Low-crystalline carbonic apatite has the most effective osteoconduction capacity 1,2 . The chemical compositions of teeth and bone are very similar. Enamel is 96% inorganic ingredients and 4% organic ingredients and water. Dentin has a 65% : 35% ratio, whereas cementum has the ratio of 45-50% : 50-55%. Finally, alveolar bone is made up of 65% inorganic ingredients and 35% organic ingredients. Tooth dentin and cementum contain a number of bone growth factors including type I collagen and bone morphogenic protein (BMP). Type I collagen accounts for 90%, with the rest consisting of noncollagenous proteins, biopolymer, lipid, citrate, lactate, etc. Noncollagenous proteins are phosphophoryn, sialoprotein, glycoprotein, proteoglycan, BMP, etc. They can perform the role of promoting bone resorption and bone formation. Therefore, bone graft materials using teeth are considered to be potentially useful in clinics [3][4][5] . II. Osteoinduction of TeethDentin matrix has long been proven to be osteoinductive and rich in BMP 6-8 . Organic component accounts for about 20% of dentin weight and mostly consists of type I collagen. Moreover, it was proven to have BMP promoting cartilage and bone formation, differentiating undifferentiated mesenchymal stem cells into chondrocytes and osteogenic cells [9][10][11][12] . Noncollagenous proteins of dentin such as

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“…These constituents, especially type I collagen, are very similar to those in dentin and alveolar bone. Previous studies on AutoBT demonstrated active bone formation and remodeling through osteoconduction and osteoinduction, with little or no infection risk despite the partially opened wound after surgery 4,5,10,11) . More importantly, since AutoBT was fabricated by bio-recycling the patient's own extracted tooth, it is less technique-sensitive and is patient-friendly without any major surgery.…”

Section: Discussionmentioning

confidence: 99%

“…The organic and inorganic contents in AutoBT are very similar to those in alveolar bone. Moreover, AutoBT possesses the same capabilities as the autogenous bone graft since it showed osteoconduction, osteoinduction, and bone remodeling 4,5) . This article reports five cases of the successful use of chin bone graft and AutoBT in alveolar cleft repair.…”

Section: Introductionmentioning

confidence: 99%

Alveolar Cleft Reconstruction Using Chin Bone and Autogenous Tooth Bone Graft Material: Reports of 5 Cases

Jeong¹,

Lee²,

Kim

et al. 2013

Journal of Korean Dental Science

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cc This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ORIGINAL ARTICLEPurpose: To report the successful results of using chin bone graft and autogenous tooth bone graft material (AutoBT) in alveolar cleft patients. Materials and Methods: Five patients with alveolar cleft defects underwent alveolar bone grafting. Three patients were treated using chin bone graft, and the other two patients underwent AutoBT graft. After implant site development using chin bone graft in the fi rst three cases, endosseous implant restorations were placed. In case #4 and 5, AutoBT graft material was placed to guide the normal eruption of partially impacted maxillary right canine and to the upper docking site after distraction osteogenesis. Result: Successful implant restorations with closure of the oronasal fistula were achieved in alveolar cleft defect reconstruction using either chin bone graft (Case #1, 2, 3) or AutoBT graft material (Case #4, 5). Case #4 showed enlarged follicle of the right maxillary canine, indicating a normal eruption guide pattern. Conclusion: Both chin bone graft and AutoBT graft showed favorable outcomes in reconstructing alveolar cleft defects. Autogenous tooth bone graft opens up the possibility of avoiding harvesting autogenous bone graft with complications and morbidities.

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Clinical Study of Graft Materials Using Autogenous Teeth in Maxillary Sinus Augmentation

Abstract: The results indicated that autogenous tooth bone graft materials are appropriate for use in maxillary sinus augmentation.

Cited by 69 publications

References 16 publications

Volumetric, Radiographic, and Histologic Analyses of Demineralized Dentin Matrix Combined with Recombinant Human Bone Morphogenetic Protein-2 for Ridge Preservation: A Prospective Randomized Controlled Trial in Comparison with Xenograft

Volumetric, Radiographic, and Histologic Analyses of Demineralized Dentin Matrix Combined with Recombinant Human Bone Morphogenetic Protein-2 for Ridge Preservation: A Prospective Randomized Controlled Trial in Comparison with Xenograft

Bone graft material using teeth

Alveolar Cleft Reconstruction Using Chin Bone and Autogenous Tooth Bone Graft Material: Reports of 5 Cases

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