Clinical study of cutaneous drug eruptions in 200 patients

Patel, Ramesh; Marfatia, YS

doi:10.4103/0378-6323.38431

Cited by 89 publications

(65 citation statements)

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“…This was in cofirmity with Sharma VK et al, however Marfatia et al reported fixed drug eruption to be the most common pattern followed by urticaria, morbilliform rash and pruritus. 5,7 Similar observation was also made by Pudukadan et al where fixed drug eruption was the most common presentation (31.1%) followed by maculopapular rash, SJS-TEN and urticaria (Table 2). 6 Antimicrobial group of drugs were found to be the most common culprit (29.33%) in our study as opposed to Marfatia et al where NSAIDS formed the major group (21%).…”

Section: 6supporting

confidence: 67%

A clinical study of cutaneous adverse drug reactions

Shah

Agrawal

Bhuptani

2017

Int J Basic Clin Pharmacol

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Background: Adverse cutaneous drug reactions pose a diagnostic challenge due to a myriad of clinical manifestations and wide variety of causative agents. Present study aims to record various clinical patterns of adverse drug reactions, their causative agents and to study the pattern of morbidity and mortality in patients with severe cutaneous adverse drug reactions.Methods: 150 patients with adverse cutaneous drug reactions were included who came to Department of Dermatology, Venereology and Leprosy at PDU Govt. Medical College and Hospital, Rajkot, Gujarat from September 2009 to September 2011. Thorough history with all routine haematological and biochemical investigations, septic screening were done. HIV testing was done in severe reactions. Appropriate specific treatment was given with counselling regarding the offending drug.Results: The most common age group was 21-30 years (26.67%) with male to female ratio being 0.92:1. Morbilliform rash was the most common clinical type (42.67%) in both HIV reactive and non-reactive patients. Antimicrobials were the most common group (29.33%) and nevirapine was the most common offending drug (27.33%). Mortality rate was 2% (3 out of 150 cases) and all the patients were of toxic epidermal necrolysis.Conclusions: The pattern of cutaneous adverse drug reactions and the causative drugs are remarkably different in our study. Knowledge of the pattern and the causative agent helps in better management and reduced consequences in these patients particularly in severe adverse cutaneous drug reactions.

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Section: 6supporting

confidence: 67%

A clinical study of cutaneous adverse drug reactions

Shah

Agrawal

Bhuptani

2017

Int J Basic Clin Pharmacol

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“…Previous studies also suggest FDE as the most common type of cutaneous ADRs. 3,14,15 The most commonly incriminated drugs in our study are NSAIDs (41.66%), anti-microbials (25%), anti-convulsants (25%), anti-diarrhoeal (3.33%), anti-neoplastic (3.33%), corticosteroids (3.33%) and herbal medicine (3.33%). In the present study, herbal medicine caused 1.66% of cutaneous ADRs which included SJS (one case).…”

Section: 12-15mentioning

confidence: 99%

Drug-induced cutaneous adverse drug reactions in dermatology in Dr. B.R. Ambedkar Medical College

Bai¹,

Padma²,

Mohan

et al. 2014

Int J Basic Clin Pharmacol

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“…A community study in India also showed that NSAID is the major cause for SJS/ TEN and exanthema in drug allergy. 9 Moreover, Noguera-Morel et al 10 also showed a similiar result in their study of pediatric drug allergy.…”

Section: Discussionmentioning

confidence: 91%

“…Several studies have discovered that antibiotic and antiinflammatory is the major causative agent in drug allergy. 3,8,9 Another study in Malang, Indonesia, also showed that paracetamol and penicillin are the major suspected causative drugs for drug allergy in pediatrics. 4 The majority of the suspected causative drugs generates the drug allergy when it is given as a single drug, and not combined with the other drug, except for anti-tuberculosis drugs which is always given as a combination of several different antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Drug Allergy Clinical Characteristics in Pediatrics

Almira¹,

Sapartini²,

Yunivita³

2017

amj

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Background: A drug allergy causes a morbidity and a mortality due to its various range of clinical manifestation. Unfortunately, a study focusing in pediatric drug allergy is insufficient, especially in Bandung. Thus, this study is conducted to determine the clinical characteristic of pediatric drug allergy in Dr. Hasan Sadikin General Hospital Bandung. Methods: This study was a retrospective descriptive study using medical records of pediatric drug allergy patients between 2010-2015 in Dr. Hasan Sadikin General Hospital Bandung taken with total sampling method. The variables were patient age, gender, causative drug, and clinical manifestation. Clinical manifestation was then divided into exanthem, urticaria, erythema multiforme, Steven-Johnson's syndrome/ toxic epidemiolytic necrosis (SJS/TEN), and fixed drug eruption (FDE). Results: Out of 101 patients, only 71 were included in the study due to incomplete medical records of the rest. There were 34 (47.89%) males and 37 (52.11%) females. Patients' age ranged from 1-18 years old with the mean of 7.4 years old. The most common clinical manifestation was SJS/TEN with 25 (35.21%) patients, followed by exanthem with 22 (30.98%) patients. The most common suspected causative drug was non-steriodal anti inflammatory drugs (NSAID) (24%), followed with penicillin (21%). Conclusions: Most common manifestation of pediatric drug allergy in female is SJS/TEN, meanwhile in male is exanthema. Steven-Johnson's syndrome/toxic epidemiolytic necrosis mostly occurs at the age group of 12-18 years old, and exanthema at the age group of 0-3 years old. This condition is mostly caused by NSAID and penicillin.

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Clinical study of cutaneous drug eruptions in 200 patients

Cited by 89 publications

References 0 publications

A clinical study of cutaneous adverse drug reactions

A clinical study of cutaneous adverse drug reactions

Drug-induced cutaneous adverse drug reactions in dermatology in Dr. B.R. Ambedkar Medical College

Drug Allergy Clinical Characteristics in Pediatrics

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