Clinical study of colorectal cancer operation: Survival analysis

Abstract

Purpose: Overall 5-year survival rates for colon and rectal cancer reported recently by the American Cancer Society were 89%, 90% for localized disease, 71%, 71% for regional disease, and 14%, 15% for distant disease. But the results of survival rate of colorectal cancer in a single institution were very rare. The aim of this study is to evaluate surgical results and survival rates of colorectal cancer. Methods: We conducted a retrospective study with patients who underwent curative resection for a primary colorectal adenocarcinoma between 2009 and 2018. Results: Five-year overall and disease-free survival were 79.5% and 69.9%, respectively. The overall 5-year survival by stages was 94.7% in stage I, 88.4% in stage II, 74.3% in stage III and 31.5% in stage IV. Five-year disease-free survival was 91% in stage I, 79.8% in stage II, 63.3% in stage III, and 18.9% in stage IV. The overall 5-year survival in rectal cancer was superior to colon cancer (P=0.014) while there was no difference in 5-year disease-free survival (P=0.338). Overall survival in female patients was better than male patient (P=0.029). Overall survival by age was worst in group of less than 40 years old (62.5%), and best in group between 41 and 65 years old (86.5%). Postoperative mortality within 30 days was 0.4%, and the recurrence rate was 19.2%. Conclusion: With the development of surgical skills and various treatments, postoperative outcome of colorectal cancer is expected to improve. It may be helpful for surgeons to improve their surgical outcomes when they review their data and conduct active researches.

Ethyl Protocatechuate Encapsulation in Solid Lipid Nanoparticles: Assessment of Pharmacotechnical Parameters and Preliminary In Vitro Evaluation for Colorectal Cancer Treatment

“…Colorectal cancer (CRC) is one of the most diffused tumoral diseases, heavily connected to environmental and lifestyle-related causes [ 1 ], with worrying higher recurrence and death rates the more developed the cancer is and the more unfavorable the genetic analysis results are [ 2 , 3 ]. Screening and prevention have been demonstrated to be very effective in reducing the odds of the development of severe illness [ 1 , 4 ], while for the currently available treatments there is a lack of late-term efficacy on both physiological and psychological symptoms, since the illness itself and most medicaments too are strongly debilitating [ 5 ].…”

Diabetic severity and oncological outcomes of colorectal cancer following curative resection: A population‐based cohort study in Taiwan

“…The mortality rate was 27.5 deaths per 100,000 people 3,4 . The prognosis of CRC, including overall survival (OS) and disease‐free survival (DFS), is inversely correlated with the disease stage 5,6 …”

“…3,4 The prognosis of CRC, including overall survival (OS) and diseasefree survival (DFS), is inversely correlated with the disease stage. 5,6 Poor prognostic factors of CRC following curative resection may be divided into three categories. 2,7,8 The first is tumor-related pathological factors, which include the advanced extent of tumor invasion, lymphatic metastasis, neurovascular, and poor histologic grade of differentiation.…”

Nanomaterial-Based Fluorescence Resonance Energy Transfer (FRET) and Metal-Enhanced Fluorescence (MEF) to Detect Nucleic Acid in Cancer Diagnosis

“…Cancer is one of the dominant and highly influential diseases in human life. Even though the five-year survival rates have gradually increased, the death rate is still above 0.1%, and the cancer incidence is approximately 0.4% [1,2]. In addition, cancer has become more frequent due to the increasing lifespan.…”