Clinical Study of Carcinoma in Situ of the Urinary Bladder

Abstract

For both primary and secondary CIS, the 5-year survival rate was about 90% and 5-year bladder preservation rate was over 50%. There was no significant difference between the primary and secondary group. The group of immediate total cystectomy was not significantly differ from the groups of the following total cystectomy and the bladder preservation in the effect of total cystectomy on the survival rate. About intravesical therapy, BCG was very effective in CR rate and the bladder preservation rate seemed to be better (but not significantly) in BCG group than in chemotherapy or non-treatment group.

Long-term Outcome of a Low-dose Intravesical Bacillus Calmette–Guerin Therapy for Carcinoma In Situ of the Bladder: Results After Six Successive Instillations of 40 mg BCG

“…In previous studies, the CR rate after BCG (Tokyo 172 strain) instillation for CIS of the bladder was reported to be 78-84% at a dose of 80 mg (12,18). At a dose of 40 mg, the CR rate was documented to be 78-85% in the group treated by instillation 10 times (15,19) and 69-70% in the group treated by instillation eight times (16,17), respectively.…”