Clinical study of azoospermia

Abstract

This study evaluated how many patients with azoospermia might have fertility potential using assisted conception techniques. A total of 102 male patients with azoospermia were included in the study. Thirteen patients had sex chromosomal abnormalities. Testicular biopsy performed in the other 89 patients showed incomplete spermatogenesis in 47 of them whereas 42 had complete spermatogenesis. In the latter 42 patients, distal vasography demonstrated bilateral obstruction of the excurrent ducts in 14 patients whereas no distal obstruction of the ducts was found in 28. The 89 patients were divided into three groups according to the findings of testicular biopsy and distal vasography. In the 14 patients with both complete spermatogenesis and distal obstruction of the excurrent ducts, surgical procedures are applicable. The pathogenesis of the 28 patients with complete spermatogenesis but without distal obstruction of the ducts should be clarified for further treatment.

Assessment of Seminal Estradiol and Testosterone Levels as Predictors of Human Spermatogenesis

“…Histological evidence showed maturation arrest (MA), Sertoli cell-only syndrome (SCOS), and tubular sclerosis/atrophy in these patients (Matsumiya et al, 1994). For NOA patients, at least 4 sites were randomly biopsied from each testis.…”

Molecular analysis of testis biopsy and semen pellet as complementary methods with histopathological analysis of testis in non-obstructive azoospermia

“…Hence, azoospermia is the cause of infertility in more than 10 % of men with infertility [1,2]. At the present time, testis biopsy is a more reliable and effective procedure in assessing the presence of mature sperm in NOA testis and its quality for use in fresh or frozen TESE/ICSI cycles.…”

“…Non-obstructive azoospermia (NOA) due to the failure of spermatogenesis is seen in about 10 % of infertile men and it is defined as the lack of mature sperm in semen [1,2]. The introduction of testicular sperm extraction (TESE) in combination with intracytoplasmic sperm injection (ICSI) raised hope in men with azoospermia to conceive their own biological child [3].…”

Relationship Between Hormone Levels and Testicular Biopsies of Azoospermic Men

“…Azoospermia is found in approximately 15-20% of men who are evaluated for infertility [15]. Several etiologies for azoospermia exist, but the prospects of fertility in every case are very poor [25].…”