Clinical study of adjuvant therapy on ischemic stroke with salviae miltiorrhizae and ligustrazine

Tian, Jing-Qin; Zhang, Wei

doi:10.12980/jad.6.2017jadweb-2016-0056

Cited by 6 publications

(2 citation statements)

References 23 publications

(18 reference statements)

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“…27 TMP has been reported to exhibit a wide range of pharmacological activities, 28 such as anti-inflammatory, 29 antithrombosis, 30 antitumor, 31 neuroprotective, 32,33 suppression of lipid accumulation, 34 expansion of blood vessels, 35,36 and cardiomyocytes protection properties. 37 However, the high sublimation propensity of TMP under ambient condition 38,39 affects its manufacturing and clinical applications. In this work, we have explored the possibility of forming a cocrystal between GEN and TMP to overcome their respective pharmaceutical problems, while attaining potential synergistic pharmacological effects.…”

Section: ■ Introductionmentioning

confidence: 99%

“…TMP has been reported to exhibit a wide range of pharmacological activities, such as anti-inflammatory, antithrombosis, antitumor, neuroprotective, , suppression of lipid accumulation, expansion of blood vessels, , and cardiomyocytes protection properties . However, the high sublimation propensity of TMP under ambient condition , affects its manufacturing and clinical applications.…”

Section: Introductionmentioning

confidence: 99%

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Drug–Drug Cocrystallization Simultaneously Improves Pharmaceutical Properties of Genistein and Ligustrazine

Liu

Song

et al. 2021

Crystal Growth & Design

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The oral delivery of genistein (GEN) is hindered by its low bioavailability. The delivery of tetramethylpyrazine (TMP or ligustrazine) is faced with physical instability challenges due to its high sublimation tendency. We tackled respective challenges of the two drugs by forming a cocrystal. The GEN-TMP cocrystal exhibits a significantly reduced sublimation tendency than TMP and a significant enhancement in both the in vitro release rate and bioavailability in rats than GEN. Thus, cocrystallization simultaneously improves pharmaceutical properties of both parent drugs.

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