Clinical Studies with an Antigonadotropin-Danazol

Greenblatt, R. B.; Dmowski, W. Paul; Mahesh, Virendra B.; Schöler, H. F.

doi:10.1016/s0015-0282(16)38045-1

Cited by 212 publications

(56 citation statements)

References 7 publications

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“…There has been considerable experience with the administration of danazol to normals (35), women with endometriosis (36), and individuals with hereditary angioedema (14,15). The most common adverse effects include weight gain, water retention, acne, decreased breast size, monilial vaginitis, mild hirsutism, and menopause-like symptoms, all of which are reversible with cessation of therapy.…”

Section: Resultsmentioning

confidence: 99%

Danazol-induced Augmentation of Serum α1-Antitrypsin Levels in Individuals with Marked Deficiency of this Antiprotease

Gadek¹,

Fulmer²,

Gelfand³

et al. 1980

J. Clin. Invest.

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A B S T R A C T Individuals with serum al-antitrypsin levels below 80 mgldl are clearly at risk for the development of accelerated panacinar emphysema. One possible approach to the therapy of this disorder would be to raise serum levels of this major antiprotease to establish protease-antiprotease homeostasis within the lung parenchyma. Because danazol, an impeded androgen, elevates levels of Cl inhibitor in patients deficient of that serum antiprotease, we hypothesized that this agent might also increase acl-antitrypsin levels in patients with al-antitrypsin deficiency. To evaluate this concept, seven patients with severe emphysema associated with al-antitrypsin deficiency (six PiZ and 1 MDUarteZ) and one asymptomatic individual (PiSZ) received 600 mg of danazol daily for 30 d. Five of the six PiZ patients responded to danazol therapy with significant increases in serum al-antitrypsin levels (mean increase of 37%; P < 0.03). The two individuals who were heterozygous for the Z protein increased their serum levels by 85% (PiMDuar,eZ) and 87% (PiSZ), respectively. These increases in serum al-antitrypsin antigen were accompanied by commensurate increases in serum trypsin inhibition. Crossed immunoelectrophoresis showed no alterations of the microheterogeneity of the al-antitrypsin or the presence of protease-antiprotease complexes in serum during danazol therapy. These data demonstrate that serum al-antitrypsin levels can be augmented by danazol therapy in PiZ individuals as well as those heterozygotes with

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Section: Resultsmentioning

confidence: 99%

Danazol-induced Augmentation of Serum α1-Antitrypsin Levels in Individuals with Marked Deficiency of this Antiprotease

Gadek¹,

Fulmer²,

Gelfand³

et al. 1980

J. Clin. Invest.

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“…& Danazol: It is an antigonadotrophin agent. Danazol is a testosterone derivative and has mild androgenic effect [31]. Current practice in India is to start treatment at 50 mg once daily and then increase to 50 mg twice daily if the response is not complete.…”

Section: Hormone Replacement Therapy and Breast Painmentioning

confidence: 99%

A Systematic Review of Current Understanding and Management of Mastalgia

et al. 2013

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Breast pain or mastalgia is the common symptom in the breast. The two most common concerns of patients presenting with mastalgia are: the fear that breast pain is a symptom of breast cancer and the presence of severe pain that affects a woman's quality of life. Breast pain requires thorough assessment and should be investigated in the same manner as any other breast symptom. We conducted a systematic review of treatment for breast pain. We searched various reviews, randomized controlled trial, and observational studies over Pubmed and Medline via internet. Searches were carried out on MEDLINE

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“…Some patients prefer to have the lump excised because of pain, discomfort, psychological reasons, or fear of cancer. Hormonal manipulation has been attempted to suppress the growth of fibroadenoma with antiestrogenic drug tamoxifen as fibroadenoma is considered to arise from hyperresponsiveness of lobular tissue to estrogen [5][6][7]. Presence of estrogen receptors on tissue obtained from fibroadenoma has been described [8].…”

Section: Introductionmentioning

confidence: 99%

Regression of Fibroadenomas with Centchroman: a Randomized Controlled Trial

et al. 2013

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Fibroadenoma is a common cause of breast lump in young girls. Nearly 10-15 % of lesions regress spontaneously over the period of 6 to 60 months. The aim of study was to investigate the role of Centchroman in regression of fibroadenoma in comparison to natural observation and to study the association of hormonal receptors with degree of regression. The study was carried out at the outpatient clinic of Department of Surgery, All India Institute of Medical Sciences, New Delhi, from November 2004 to November 2007. Patients aged ≤30 years with fibroadenoma were included. Patients with fibroadenoma equal to or larger than 5 cm and with polycystic ovarian disease were excluded. Patients were randomized in two groups. Patients in active therapy arm were prescribed Centchroman 30 mg daily for 12 weeks, and another group was observed without any intervention (control group). Patients were followed at weeks 4, 8, 12, and 24 to assess response to therapy. Twenty-two (31.88 %) fibroadenomas in Centchroman arm disappeared completely as compared to four (7.69 %) in control arm over a period of 6 months.There was a decrease in the volume of fibroadenoma in ten (19.23 %) patients in control arm and 36 (52.17 %) patients in Centchroman arm. Centchroman therapy allowed 31 % fibroadenoma to regress completely with scanty menses or amenorrhea as the only side effect.

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Clinical Studies with an Antigonadotropin-Danazol

Cited by 212 publications

References 7 publications

Danazol-induced Augmentation of Serum α1-Antitrypsin Levels in Individuals with Marked Deficiency of this Antiprotease

Danazol-induced Augmentation of Serum α1-Antitrypsin Levels in Individuals with Marked Deficiency of this Antiprotease

A Systematic Review of Current Understanding and Management of Mastalgia

Regression of Fibroadenomas with Centchroman: a Randomized Controlled Trial

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