Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis

Hamilton-Reeves, Jill; Vázquez, Gabriela; Duval, Sue; Phipps, William R.; Kurzer, Mindy S.; Messina, Mark

doi:10.1016/j.fertnstert.2009.04.038

Cited by 101 publications

(68 citation statements)

References 75 publications

(102 reference statements)

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“…Rats exposed to a phytoestrogen-rich diet (40 mg/kg or 600 mcg/g of isoflavones) had significantly lower prostate weights and lower concentration of testosterone and andorostenedione, compared with rats fed a phytoestrogen free diet [122,123]. In men, however, ingestion of isoflavones did not have a significant impact on testosterone, SHBG, free testosterone and free androgen index [124]. There is evidence that isoflavone consumption affects endogenous oestrogen levels (and its metabolites) in men [125,126].…”

Section: Prostate Cancermentioning

confidence: 91%

Does equol production determine soy endocrine effects?

et al. 2012

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Isoflavones, a group of phytoestrogens, are selective oestrogen receptor (ER) modulators. They may positively impact endocrine-related conditions but the current evidence is sparse. Equol, a non-steroidal oestrogen, is produced by the metabolism of the isoflavone daidzein by intestinal bacteria. In Western countries, 30-50% of individuals metabolize daidzein into equol and are known as equol producers. Equol production may be the source of benefit from isoflavones in endocrine disease.

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Section: Prostate Cancermentioning

confidence: 91%

Does equol production determine soy endocrine effects?

et al. 2012

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“…A meta-analysis of 15 placebocontrolled studies has also shown that the incorporation of soy foods does not alter the bioavailability of testosterone concentrations in men. 31 Contrary to this, some epidemiological studies have shown the protective effects of phytoestrogens in females against breast cancer. It has also been found that females with history of breast cancer should consume the soya products with caution since soybean can stimulate the growth of estrogen receptor-positive cells in vitro.…”

Section: Effect Of Phytoestrogens On Humansmentioning

confidence: 98%

Phytoestrogens as Pharma Foods

Gupta¹,

Prakash²,

Gupta³

2016

Adv Food Technol Nutr Sci Open J

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Phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens and show potential benefits for human health. They can serve as potential alternatives to the synthetic selective estrogen receptor modulators which are currently being used in hormone replacement therapy. Estrogens play many important physiological roles in men and women. In women, life is severely affected by a variety of estrogen-related conditions such as osteoporosis, cognitive and cardiovascular disease, increased risk of breast cancer and other symptoms that decrease the overall quality of life. Phytoestrogens are effective in maintaining bone mineral density, prevent bone loss, and help in the prevention and/or treatment of such health related problems. They can be classified as flavonoids, isoflavonoids, coumestans, stilbenes, lignans and terpenoids. The main isoflavones, genistein and daidzein found in soybean, can exist as glucosides or as aglycones, and are readily hydrolyzed in the gut to their aglycones. The aglycones are easily transported across intestinal epithelial cells. Terpenoids (ferutinine, tschimgine, and tschimganidine) found in the Umbelliferae family have estrogenic activities. The main dietary source of phytoestrogenic stilbenes is trans-resveratrol from red wine and peanuts. Plant-derived foods may be an adequate source for a variety of phytoestrogens capable of producing a range of pharmacological effects and protection from various life threatening diseases. This article provides the comprehensive information about the main groups of phytoestrogens, their food as well as herbal or botanical sources, potential health benefits and probable health hazards.

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“…Although some studies reported decreases (88,107), a recently published metaanalysis by Hamilton-Reeves et al (108) concluded that neither soy protein nor isoflavone intake affects circulating levels of total T, sex hormone binding globulin, free T, or the free androgen index. The metaanalysis included 15 placebo-controlled treatment groups, with baseline and ending measures, and 32 reports involving 36 treatment groups in which hormones were assessed in simpler models.…”

Section: Soy Isoflavones and Testosteronementioning

confidence: 99%

Soybean isoflavone exposure does not have feminizing effects on men: a critical examination of the clinical evidence

Messina

2010

Fertility and Sterility

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Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis

Cited by 101 publications

References 75 publications

Does equol production determine soy endocrine effects?

Does equol production determine soy endocrine effects?

Phytoestrogens as Pharma Foods

Soybean isoflavone exposure does not have feminizing effects on men: a critical examination of the clinical evidence

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