Clinical Studies of the Blood Volume. Iii. Changes in Blood Volume, Venous Pressure and Blood Velocity Rate in Chronic Congestive Heart Failure

Gibson, David J.; Evans, William A.

doi:10.1172/jci100911

Cited by 96 publications

(29 citation statements)

References 13 publications

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“…In comparison with a group of cases with congestive heart failure (29) capacity of a unit mass of blood due to the red cell deficit and plasma dilution, the rate of flow is increased in relation to the lowered viscosity of the blood. During recovery the significant change is the increase in circulating red cell volume, and the relation of this increase to the course of plasma volume is such that total blood volume slowly rises from the subnormal level present in the severe stages to within normal limits for the individual when recovery is complete.…”

Section: Blood Volumementioning

confidence: 85%

Clinical Studies of the Blood Volume. Viii. Macrocytic and Hypochromic Anemias Due to Chronic Blood Loss, Hemolysis and Miscellaneous Causes, and Polycythemia Vera 1

Gibson¹,

Harris²,

Swigert³

1939

J. Clin. Invest.

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Section: Blood Volumementioning

confidence: 85%

Clinical Studies of the Blood Volume. Viii. Macrocytic and Hypochromic Anemias Due to Chronic Blood Loss, Hemolysis and Miscellaneous Causes, and Polycythemia Vera 1

Gibson¹,

Harris²,

Swigert³

1939

J. Clin. Invest.

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“…Since the association between anoxemia and compensatory polycythemia is well established, measurements of arterial and venous oxygen were made and it proved possible to show a rough quantitative relationship between anoxemia and cellular increase. On the other hand, while the statement has been made (1,2) that there is a positive relationship between the venous pressure and the change in blood volume in congestive heart failure, it was not possible to find such a relationship within this group of severely congested cardiac patients.…”

mentioning

confidence: 87%

“…The results of these studies conducted on cardiac patients are therefore presented in full. 1 Louisiana State University School of Medicine, New Orleans, La.…”

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confidence: 99%

A Study of the Volume of the Blood in Congestive Heart Failure. Relation to Other Measurements in Fifteen Patients

Meneely

Kaltreider²

1943

J. Clin. Invest.

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While the volume of the blood in health is quite constant and closely related to the size, age, and sex of the individual, it has long been recognized that in congestive heart failure, this relationship is disturbed. Therefore, investigations of the volume of the blood in this clinical condition should throw light on the mechanism of normal control of the volume of the blood as well as on the nature of the physiological disturbances involved in heart failure itself. Studies of this nature, summarized by Gibson and Evans (1), indicate that there is an increase in the volume of the blood in this condition. While this generality is well supported, there is a striking variability in individual cases. It appeared likely that this variability might be accounted for if quantitative measurement of factors which might influence blood volume were made at the time of the determination of the blood volume. Since the association between anoxemia and compensatory polycythemia is well established, measurements of arterial and venous oxygen were made and it proved possible to show a rough quantitative relationship between anoxemia and cellular increase. On the other hand, while the statement has been made (1, 2) that there is a positive relationship between the venous pressure and the change in blood volume in congestive heart failure, it was not possible to find such a relationship within this group of severely congested cardiac patients.Although a number of the lines of investigation pursued did not lead to the establishment of any simple correlation with plasma or cell volume changes, these data presented are of interest, not only in themselves, but also because certain interesting relations obtain between them. The results of these studies conducted on cardiac patients are therefore presented in full.1 Louisiana State University School of Medicine, New Orleans, La. MATERIALFifteen patients were selected who had clinical evidence of severe congestive heart failure (class IV). All were dyspneic or orthopneic, all but one had pitting edema, all but one had hepatomegaly, most had chronic passive congestion of the lungs, a few had hydrothorax, several had ascites. The clinical findings in these patients are summarized in Table I. Every effort was made to select uncomplicated cases, who were untreated, or who were in a steady state despite digitalis. Etiology of the heart disease in these cases included rheumatic heart disease, arteriosclerosis, hypertension, thyrotoxicosis, syphilis, and heart disease secondary to pulmonary disease. The duration of failure ranged from a few weeks to several years. Patient number seven had evidence of a moderate degree of renal insufficiency and he also had hemoptysis. None of the others had evidence of chronic blood loss. Five patients were female and ten were male. The average age was 542 years, with one subject in the third decade, five in the fourth decade, four in the fifth, and five in the sixth decades. METHODSThe patient was brought to the laboratory in bed in the post-absorptive state. T...

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“…The lowered basal metab-,olism that obtains in nephrotic cases is well known. The circulation time is slow in myxedema (35,36) even when uncomplicated by anemia. In our opinion the depressed metabolism of the nephrotic cases probably accounts for the relatively slow blood flow at the levels of anemia exhibited by these patients.…”

Section: Fig 4 Circulation Time In Bright's Diseasementioning

confidence: 99%

Clinical Studies of the Blood Volume. Vii. Changes in Blood Volume in Bright's Disease With or Without Edema, Renal Insufficiency, or Congestive Heart Failure, and in Hypertension 1

Harris¹,

Gibson²

1939

J. Clin. Invest.

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Clinical Studies of the Blood Volume. Iii. Changes in Blood Volume, Venous Pressure and Blood Velocity Rate in Chronic Congestive Heart Failure

Cited by 96 publications

References 13 publications

Clinical Studies of the Blood Volume. Viii. Macrocytic and Hypochromic Anemias Due to Chronic Blood Loss, Hemolysis and Miscellaneous Causes, and Polycythemia Vera 1

Clinical Studies of the Blood Volume. Viii. Macrocytic and Hypochromic Anemias Due to Chronic Blood Loss, Hemolysis and Miscellaneous Causes, and Polycythemia Vera 1

A Study of the Volume of the Blood in Congestive Heart Failure. Relation to Other Measurements in Fifteen Patients

Clinical Studies of the Blood Volume. Vii. Changes in Blood Volume in Bright's Disease With or Without Edema, Renal Insufficiency, or Congestive Heart Failure, and in Hypertension 1

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