Clinical studies of human growth hormone

Root, Allen W.

doi:10.1016/s0362-5486(76)80004-0

Cited by 2 publications

(5 citation statements)

References 197 publications

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“…This apparent insulin resistance could be the result of the reported increase function of the hypothalamic-pituitary-adrenocortical axis (HPAC) producing high levels of plasma cortisol (Marco et al 1973;Lantigua et al 1980). Alterations in the sensitivity of the hypothalamic glucose receptors which are reportedly stimulated by alpha and inhibited by beta adrenergic and serotonergic input may also be involved (Root, 1976). Further analyses of these data, together with data available on the HPAC and neurotransmitter systems, should help to clarify these relationships.…”

Section: Discussionmentioning

confidence: 99%

“…Pearson correlation coefficients for hGH sample replicate reliabilities were all 0-97 or higher, and those for plasma glucose were 0-95 or higher. hGH secretion may be altered by a variety of stimuli, including emotional and physical stress, diet, and other endogenous and exogenous factors (see review by Root, 1976). In order to control for these variables, when analysing the hGH response to ITT, subjects were included for analysis only if all of the following 4 criteria were met:…”

Section: Methodsmentioning

confidence: 99%

“…(2) No greater than a 20% deviation from ideal body weight (Davidson et al 1975) in order to control for obesity and malnourishment, both of which produce aberrant hGH responses to provocative stimuli (Root, 1976).…”

Section: Methodsmentioning

confidence: 99%

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Insulin Tolerance Test: human growth hormone response and insulin resistance in primary unipolar depressed, bipolar depressed and control subjects

Koslow¹,

Stokes

Mendels³

et al. 1982

Psychol. Med.

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SynopsisPreliminary data from the National Institute of Mental Health – Clinical Research Branch Collaborative Program on the Psychobiology of Depression dealing with the human growth hormone (hGH) response to the Insulin Tolerance Test (ITT) during the pre-treatment (drug-free) period of the study are presented in this paper. Data are reported for 54 unipolar depressed, 21 bipolar depressed, and 40 normal control subjects, who represent approximately 50% of the final subject sample to be studied. In this population the unipolar depressed subjects showed a significantly greater resistance to insulin-induced hypoglycaemia than bipolar and control subjects. After applying the inclusion/exclusion criteria necessary to interpret hGH responses accurately, the data from only 54 subjects were acceptable. Mean peak hGH concentrations were not significantly different among the three groups. There was, however, a significant difference in the distributions of the hGH peak response, with the bipolar depressed population demonstrating greater variability in response than unipolar and control populations. These findings are discussed as they relate to previous reports and theoretical considerations.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Insulin Tolerance Test: human growth hormone response and insulin resistance in primary unipolar depressed, bipolar depressed and control subjects

Koslow¹,

Stokes

Mendels³

et al. 1982

Psychol. Med.

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“…(2) Deviation of body weight from ideal body weight, > 20% (Davidson et al 1975). This was considered necessary to control for obesity and malnourishment, both of which may produce abnormal GH responses to stimuli (Roth et al 1964;Root, 1976). For example, Root (1976) reported that the insulin-induced growth hormone response was lowered in obese subjects.…”

Section: Exclusion Criteriamentioning

confidence: 99%

“…This was considered necessary to control for obesity and malnourishment, both of which may produce abnormal GH responses to stimuli (Roth et al 1964;Root, 1976). For example, Root (1976) reported that the insulin-induced growth hormone response was lowered in obese subjects. Similarly, Smith et al (1973) reported that severe protein-calorie malnutrition of adults lowers the growth hormone response to hypoglycaemia, although not all investigators have found this (Alvarez et al 1972).…”

Section: Exclusion Criteriamentioning

confidence: 99%

Insulin-induced hypoglycaemic response and release of growth hormone in depressed patients and healthy controls

et al. 1988

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SynopsisAs part of the Collaborative Study of the Psychobiology of Depression, we have examined the pretreatment growth hormone response (ΔGH) to insulin (0·1 U/kg) and the magnitude of the hypoglycaemic response in a large number of well-defined depressed patients (N = 132) and healthy controls (N = 80). After applying rigorous exclusion criteria, data were analysed from 93 patients and 66 controls for blood glucose response and from 56 patients and 52 controls for ΔGH. Depressed patients, either unipolar or bipolar, showed less of a fall in glucose than controls. A weak association was found between the magnitude of the fall in glucose and the severity of depression. No significant differences were found in values for ΔGH between the unipolar or bipolar depressed patients and controls either for males, pre-menopausal or postmenopausal females, or the total female group. These data do not support previous claims of a lowered ΔGH response to insulin in depressed patients. However, the resistance to hypoglycaemia seen in the depressed patients is consistent with previous reports.

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Clinical studies of human growth hormone

Cited by 2 publications

References 197 publications

Insulin Tolerance Test: human growth hormone response and insulin resistance in primary unipolar depressed, bipolar depressed and control subjects

Insulin Tolerance Test: human growth hormone response and insulin resistance in primary unipolar depressed, bipolar depressed and control subjects

Insulin-induced hypoglycaemic response and release of growth hormone in depressed patients and healthy controls

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