Clinical status and behavior of patients with hyperprolactinemic hypogonadism treated by selected dopamine agonists

Abstract

Mental status and behavior were studied in 19 women aged 18-45 years with hyperprolactinemic hygonadism of different forms treated by selective dopamine receptor agonists (4 patients were treated with chinagolide and 15 with cabergolide). Appreciable improvement of the general clinical status was attained: biphasic menstrual cycle was restored, galactorrhea decreased, and prolactin level normalized. Sexual disorders and headaches reduced. Mental status improved: anxiety, depression, and severity of neurovegetative symptoms decreased. Hamilton score (anxiety) decreased from 16.5 to 9.1. Versatile personality investigation showed de creased profiles of the first, third, seventh, and eighth scales, which indicates decreased affective strain, reduction of psychological partitioning and sense of one's own inadequacy, and decreased liability to exert psychological pressure on other people by means of somatic symptoms available. However, these positive shifts in the mental status of patients were insufficiently complete and stable, despite the continuing decrease in prolactin level.