Clinical States Associated with Alterat of the Hemoglobin Molecule

Molecular structure and biological specificity; a symposium sponsored by the Office of Naval Research and arranged by the American Institute of Biological Sciences, held in Washington, D.C., October 28, 29, 1955

“…The normal hemoglobins of man are fetal (F), present in fetal life and in early infancy, and adult (A). Electrophoretic studies have disclosed the existence of a number of abnormal forms which are inherited modifications of the adult hemoglobin (Pauling, et al, 1949;Itano, 1955). The adult form and its modifications are probably determined by a series of allelic genes (Itano, 1953a), so that a person can have either one or two of these forms, depending upon whether he is homozygous in one of the genes or heterozygous; he can have no more than two since an individual can have only one pair of genes at any allelic site.…”

Thalassaemia in a Gurkha Family

“…This may be responsible in some degree for her present liver enlargement. Relatively low levels of foetal haemoglobin are not unknown in thalassaemia major (Itano, 1955).…”

Unusual Haemoglobin Variant in a Gujerati Indian

“…The letter was originally reserved by Itano (1955) for a component reported by Battle and Lewis (1954), but subsequently he could not confirm that this was a distinct variant . At the sixth International Congress of Haematology it was suggested that K might describe another haemoglobin reported from Algeria by Cabannes et al (1956), and one of the new vatiants (Liberia II) found by Robinson et al (1956) in Liberia.…”

“…At pH 6.5 in phosphate buffer, however, the abnormal haemoglobin was not separable from haemoglobin A, but trailed behind it. The solubility of Mrs. L. M.'s haemoglobin was 1.57 g. per litre in 2.58 M phosphate buffer, by the method of Itano (1953). After ten weeks' storage at about -25°C.…”