Clinical staging model in offspring of parents with bipolar disorder: a systematic review

Raouna, Aigli; Osam, Cemre Su; MacBeth, Angus

doi:10.1111/bdi.12604

Cited by 22 publications

(16 citation statements)

References 89 publications

(439 reference statements)

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“…A recent meta-analysis staging the developmental symptoms preceding full blown bipolar disorder (BP) (Raouna et al, 2018) showed that the childhood precursors of the disease mainly consist of non-mood disorders (anxiety disorders, ADHD, disruptive behavioural disorders). In a previous study on offspring aged 10-18 years of parents with BP type-1 (BP-I) we showed that ADHD was the most prevalent disorder in boys, while anxiety disorders and depressive spectrum disorders were the most prevalent disorders in girls compared with same sex offspring of healthy parents (Grigoroiu-Serbanescu et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Predictive power of the ADHD GWAS 2019 polygenic risk scores in independent samples of bipolar patients with childhood ADHD

Grigoroiu‐Serbanescu

Giaroli

Thygesen

et al. 2020

Journal of Affective Disorders

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Background: Although there is evidence of genetic correlation between bipolar disorder (BP) and ADHD, the extent of the shared genetic risk and whether childhood ADHD (cADHD) influences the characteristics of the adult BP remain unclear. Our objectives were: (i) to test the ability of polygenic risk scores (PRS) derived from the latest PGC ADHD-GWAS (Demontis et al., 2019) to predict the presence of cADHD in BP patients; (ii) to examine the hypothesis that BP preceded by cADHD is a BP subtype with particular clinical traits and (iii) partially shares its molecular basis with ADHD.Method: PRS derived from the ADHD-GWAS-2019 were tested in BP patients (N=942) assessed for cADHD with the Wender Utah Rating Scale and in controls from Romania and UK (N=1616). Results:The ADHD-PRS differentiated BP cases with cADHD from controls. Proband sex and BP age-of-onset significantly influenced the discriminative power of the ADHD-PRS. The ADHD-PRS predicted the cADHD score only in males and in BP cases with early age-of-onset (≤21 years). Bipolar patients with cADHD had a younger age-of-onset of mania/depression than patients without cADHD.The ADHD-PRS predicted the BP-affection status in the comparison of early-onset BP cases with controls suggesting a partial molecular overlap between early-onset BP and ADHD.Limitations: Retrospective diagnosis of cADHD, small sample size. Conclusions:The PRS-analysis indicated an acceptable predictive ability of the ADHD-SNP-set 2019 in independent BP samples. The best prediction of both cADHD and BP-affection status was found in the early-onset BP cases. The results may have impact on the individual disease monitoring.

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Section: Introductionmentioning

confidence: 99%

Predictive power of the ADHD GWAS 2019 polygenic risk scores in independent samples of bipolar patients with childhood ADHD

Grigoroiu‐Serbanescu

Giaroli

Thygesen

et al. 2020

Journal of Affective Disorders

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“…High-risk youth had at least one parent diagnosed with BD or MDD. In the context of staging models of risk for mood disorders, these high-risk youth were recruited at what would be considered Stage 0, or very early along the risk continuum (Duffy, Vandeleur, Heffer, & Preisig, 2017; Raouna, Osam, & MacBeth, 2018). In addition, 27 healthy youth with no personal or family history of psychopathology (HCL) were recruited from the community by advertisements.…”

Section: Methodsmentioning

confidence: 99%

Neural correlates of emotion processing predict resilience in youth at familial risk for mood disorders

et al. 2019

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Aberrant face emotion processing has been demonstrated in youth with and at a familial risk for bipolar and major depressive disorders. However, the neurobiological factors related to emotion processing that underlie resilience from youth-onset mood disorders are not well understood. Functional magnetic resonance imaging data during an implicit emotion processing task were collected at baseline from a sample of 50 youth, ages 8–17, who were healthy but also familially at high risk for either bipolar disorder or major depressive disorder, and 24 healthy controls with no family history of psychopathology (HCL). Participants were reevaluated 3 years later and classified into three groups for analysis: high-risk youth who converted to a psychiatric diagnosis (CVT; N = 23), high-risk youth who were resilient from developing any psychopathology (RES; N = 27), and HCL youth (N = 24) who remained healthy at follow-up. For happy > calm faces, the CVT and RES groups had significantly lower activation in the left inferior parietal lobe (IPL), while the RES group had lower activation in the right supramarginal gyrus. For fear > calm faces, the RES group had lower activation in the right precuneus and inferior frontal gyrus (IFG) compared to the CVT group. Connectivity analyses revealed the RES group exhibited higher left IPL connectivity with visual cortical regions for happy > calm faces, and higher IFG connectivity with frontal, temporal, and limbic regions for fear > calm faces. These connectivities were correlated with improvements in prosocial behaviors and global functioning. Our findings suggest that differential activation and connectivity in the IPL, IFG, and precuneus in response to emotional stimuli may represent distinct resilience and risk markers for youth-onset mood disorders.

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“…By contrast, similar to two prior prospective high-risk studies (Axelson et al, 2015;Duffy et al, 2013) and one prospective community study (Paaren et al, 2014), we found no evidence that any of the subtypes of anxiety disorders were associated with the subsequent onset of (hypo)manic episodes. This challenges staging models that have posited that anxiety disorders are an early stage in the development of BPD (Raouna et al, 2018). Although longitudinal studies have consistently reported a prospective association between cannabis use and schizophrenia (Volkow, Hampson, & Baler, 2017), evidence for such an association for BPD has been inconsistent.…”

Section: Mood Episodes and Nonmood Disorders Preceding (Hypo)manic Epmentioning

confidence: 99%

“…These issues have been addressed through the application of the high-risk strategy that increases the probability of the number of cases of onset of BPD, prospective research that can track psychopathology across development to minimize inherent biases of retrospective recall, and the use of staging models to characterize developmental patterns of psychopathology across development. A recent meta-analysis suggested a trajectory of risk from nonmood disorders, such as childhood anxiety disorders, via depression in early adolescence to (hypo)manic episodes in later adolescence and early adulthood (Raouna, Osam, & MacBeth, 2018).…”

Section: Introductionmentioning

confidence: 99%

Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13‐year prospective cohort high‐risk study

Rudaz

Vandeleur

Gholam

et al. 2020

Child Psychology Psychiatry

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Background: There is still limited evidence from prospective high-risk research on the evolution of specific disorders that may emerge early in the development of mood disorders. Moreover, few studies have examined the specificity of mood disorder subtypes among offspring of parents with both major subtypes of mood disorders and controls based on prospective tracking across the transition from childhood to adulthood. Our specific objectives were to (a) identify differences in patterns of psychopathological precursors among youth with (hypo)mania compared to MDD and (b) examine whether these patterns differ by subtypes of parental mood disorders. Methods: Our data stem from a prospective cohort study of 449 directly interviewed offspring (51% female, mean age 10.1 years at study intake) of 88 patients with BPD, 71 with MDD, 30 with substance use disorders and 60 medical controls. The mean duration of follow-up was 13.2 years with evaluations conducted every three years. Results: Within the whole cohort of offspring, MDE (Hazard Ratio = 4.44; 95%CI: 2.19-9.02), CD (HR = 3.31;1.55-7.07) and DUD (HR = 2.54; 1.15-5.59) predicted the onset of (hypo)manic episodes, whereas MDD in offspring was predicted by SAD (HR = 1.53; 1.09-2.15), generalized anxiety (HR = 2.56; 1.05-6.24), and panic disorder (HR = 3.13; 1.06-9.23). The early predictors of (hypo)mania in the whole cohort were also significantly associated with the onset of (hypo)mania among the offspring of parents with BPD. Conclusions: The onset of mood disorders is frequently preceded by identifiable depressive episodes and nonmood disorders. These precursors differed by mood subtype in offspring. High-risk offspring with these precursors should be closely monitored to prevent the further development of MDD or conversion to BPD.

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Clinical staging model in offspring of parents with bipolar disorder: a systematic review

Cited by 22 publications

References 89 publications

Predictive power of the ADHD GWAS 2019 polygenic risk scores in independent samples of bipolar patients with childhood ADHD

Predictive power of the ADHD GWAS 2019 polygenic risk scores in independent samples of bipolar patients with childhood ADHD

Neural correlates of emotion processing predict resilience in youth at familial risk for mood disorders

Psychopathological precursors of the onset of mood disorders in offspring of parents with and without mood disorders: results of a 13‐year prospective cohort high‐risk study

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