Clinical spectrum of the anti-GQ1b antibody syndrome: a case series of eight patients

Bruyn, Alexander de; Poesen, Koen; Bossuyt, Xavier; Heremans, Isaac P; Claeys, Tom; Depuydt, Christophe; Damme, Philip Van; Claeys, Kristl

doi:10.1007/s13760-019-01093-8

Cited by 20 publications

(17 citation statements)

References 23 publications

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Section: Discussionmentioning

confidence: 90%

“…Anti-GQ1b or anti-GT1a have been identified in all cases. In addition, serum anti-GM1 was also detected in two cases 1,4 . Our patient would be the first described associated with isolated anti-GM1 positive titers J o u r n a l P r e -p r o o f Some potentially dangerous diseases may present with multiple or bilateral acute nerve palsies.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 90%

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What did he eat?

Rodrigo-Rey

Gutiérrez-Ortiz

Muñoz

et al. 2021

Survey of Ophthalmology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Discussionmentioning

confidence: 90%

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 90%

What did he eat?

Rodrigo-Rey

Gutiérrez-Ortiz

Muñoz

et al. 2021

Survey of Ophthalmology

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“…It has also been reported that decreased vision, ophthalmoplegia and peripheral facial paralysis are the main manifestations [ 4 ]. Although there was more than one type of antibody in the patient’s serum, this situation is not rare according to related reports of anti-GQ1b antibody syndrome [ 5 – 7 ]. Due to their close structural relationship, anti-GT1a antibodies often cross-react with anti-GQ1b antibodies.…”

Section: Discussionmentioning

confidence: 92%

Graves’ disease with anti-GQ1b antibody syndrome: a rare case report

Liang

Zhou

et al. 2021

BMC Neurol

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Background Graves’ disease and anti-GQ1b antibody syndrome are both autoimmune diseases, and there have been few reports on whether there is a correlation between the two. In this study, we present the case of a woman who was diagnosed with Graves’ disease and anti-GQ1b antibody syndrome in succession. Case presentation The chief complaints of this patient were limb weakness and blurred vision. Graves’ disease was diagnosed by examination of thyroid function and thyroid autoantibodies, but the clinical symptoms were not relieved after antihyperthyroidism treatment. Finally, it was found that Graves’ disease was complicated by anti-GQ1b antibody syndrome, and the symptoms were relieved after treatment with glucocorticoids and intravenous immunoglobulin. We also explored the possible mechanism of these diseases through a literature review. Conclusions We report a rare case of the cooccurrence of Graves’ disease and anti-GQ1b antibody syndrome. Immune dysregulation might be the pathogenesis of the association, but there is no precise supporting evidence, and more research is needed.

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“…24 Anti-Gq1b syndromes manifest along a spectrum, ranging from the peripheral nervous system predominant Miller-Fisher syndrome (typified by the clinical triad of ataxia, areflexia and ophthalmoplegia) through to central involvement in the form of Bickerstaff's brainstem encephalitis, defined by a combination of external ophthalmoplegia AND either altered level of consciousness -ranging from mild drowsiness to coma-OR hyper-reflexia [25][26][27] with a multitude of forme frustes including acute ophthalmoparesis and acute ataxic neuropathy in between. 24,28 Up to 50 percent of patients with Bickerstaff's brainstem encephalitis have coexisting GBS, but limb weakness generally follows the development of ophthalmoplegia/ ataxia rather than being present at the onset. 27 Nerve conduction studies in these patients frequently demonstrate axonal involvement.…”

Section: Could the Gbs Treatment Be Responsible?mentioning

confidence: 99%

“…The next point to consider is whether the patient could be suffering from a related, but distinct disorder, particularly anti‐Gq1b antibody‐related disease 24 . Anti‐Gq1b syndromes manifest along a spectrum, ranging from the peripheral nervous system predominant Miller‐Fisher syndrome (typified by the clinical triad of ataxia, areflexia and ophthalmoplegia) through to central involvement in the form of Bickerstaff’s brainstem encephalitis, defined by a combination of external ophthalmoplegia AND either altered level of consciousness –ranging from mild drowsiness to coma‐ OR hyper‐reflexia 25–27 with a multitude of forme frustes including acute ophthalmoparesis and acute ataxic neuropathy in between 24,28 …”

Section: Am I Dealing With a Gbs Variant (Esp Anti‐gq1b Ssease)?mentioning

confidence: 99%

Altered mental status in “Guillain‐Barré syndrome” –a noteworthy clinical clue

Mulroy

Anderson

2020

Ann Clin Transl Neurol

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Guillain-Barr e syndrome (GBS) is widely regarded as a "pure" peripheral nervous system disorder. However, this simplistic interpretation belies the fact that central nervous system involvement, often manifesting as derangements in mental status can occur as a complication of the "pure" form of the disorder, as part of GBS variants, as well as in a number of mimic disorders. Despite being common in clinical practice, there is no guidance in the literature as to how to approach such scenarios. Herein, we detail our approach to these cases.

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Clinical spectrum of the anti-GQ1b antibody syndrome: a case series of eight patients

Cited by 20 publications

References 23 publications

What did he eat?

What did he eat?

Graves’ disease with anti-GQ1b antibody syndrome: a rare case report

Altered mental status in “Guillain‐Barré syndrome” –a noteworthy clinical clue

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