Clinical spectrum of septic pulmonary embolism and infarction

MacMillan, James C.; Milstein, Stephen H.; Samson, Paul C.

doi:10.1016/s0022-5223(19)41311-1

Cited by 78 publications

(42 citation statements)

References 43 publications

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“…There is often a history of predisposing factor, e.g. drug abuse or extra pulmonary infection [13,14] or a catheter, as in our patient. The clinical features and chest radiography could be nonspecific, as in our patient, thus delaying the diagnosis.…”

Section: Discussionmentioning

confidence: 81%

“…In this study, fungal SPE was twice more common then bacterial SPE and more likely to be associated with hematological or solid malignancy compared to bacterial SPE [12]. In another study, tricuspid endocarditis was the most common cause and the drug abusers were the most common patients [13].…”

Section: Discussionmentioning

confidence: 89%

“…Only 32% of lesions visible on chest CTs were detected by chest radiographs in a study [17]. Chest CT might show patchy infiltrate, poorly defined nodule or wedge-shaped densities, which are typically multiple, sub pleural and peripheral, and located at the end of a blood vessel [13,14,17], and sometimes associated with cavitations and air bronchogram within the nodule, ground-glass halo around the nodule, pleural effusion or empyema [13,14]. These features, along with the clinical scenario, help to differentiate SPE from other causes of diffuse pulmonary nodules [18].…”

Section: Discussionmentioning

confidence: 95%

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Hemodialysis-Catheter Related Septic Pulmonary Emboli in the Absence of Endocarditis or Right Atrial Thrombus

Dahal

2013

J Med Cases

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Catheter-related bloodstream infection, although a major cause of morbidity and mortality in hemodialysis population, is rarely associated with septic pulmonary emboli (SPE). SPE is generally associated with endocarditis or right atrial thrombus. We describe a case of a young man on hemodialysis with fever, who was subsequently diagnosed to have SPE in the absence of endocarditis or right atrial thrombus.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 95%

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Hemodialysis-Catheter Related Septic Pulmonary Emboli in the Absence of Endocarditis or Right Atrial Thrombus

Dahal

2013

J Med Cases

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“…[2][3][4] In the USA, 80% of SPE patients are thought to be intravenous drug users and the most common cause is tricuspid valve endocarditis. 6 However, an increasing number of other individuals are at risk of developing SPE, including immunocompromised patients with AIDS, organ transplant recipients, and patients with long-term indwelling catheters. Considering these factors, patients undergoing chemotherapy for cancer are thought to be susceptible to SPE.…”

Section: Discussionmentioning

confidence: 99%

A case of Sweet's syndrome following septic pulmonary emboli after high‐dose chemotherapy for advanced testicular cancer

et al. 2006

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A 33-year-old man with advanced testicular cancer underwent high-dose chemotherapy combined with peripheral blood stem cell transplantation. After administration of granulocyte colony-stimulating factor (G-CSF), multiple infiltrative erythema was identified on the face, thigh, and lower leg. A dermatologist diagnosed this as Sweet's syndrome caused by G-CSF; consequently G-CSF administration was stopped. When the skin lesions had improved, phlebitis was found at the injection site of the peripheral vein catheter. The patient then suffered from sudden left chest pain and dyspnea. Chest computed tomography showed the characteristic findings of septic pulmonary emboli (SPE). He was treated by the administration of vancomycin, fluconazole, and pazufloxacin mesilate. Although Sweet's syndrome and SPE are rare diseases, the presence of these diseases must be considered when performing chemotherapy for urological malignancy.

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“…Consequently, a generalization can be made that the higher the blood flow to a specific organ or anatomic region, the higher the chance of SE traveling there. Within the thorax, there are two commonly described types of septic embolithose originating on the "left side" of the heart and involving the coronary arterial circulation or thoracic aorta [56,57], and those originating from the "right side" and involving the pulmonary arterial circuit [58][59][60].…”

Section: The Thoraxmentioning

confidence: 99%

Septic Embolism in Endocarditis: Anatomic and Pathophysiologic Considerations

Yellapu¹,

Ackerman²,

Longo³

et al. 2018

Advanced Concepts in Endocarditis

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Septic embolism is a relatively common and potentially severe complication of infective endocarditis (IE). Septic emboli (SE), most often described as consisting of a combination of thrombus and infectious material-either bacterial or fungal-can be caused by hematogenous spread from virtually any anatomic site; however, it most commonly originates from cardiac valves. During the past two decades there has been a confluence of various risk factors that, both alone and in combination, led to greater incidence of both IE and SE, including increasing population age, greater use of prosthetic valves, implantation of various intracardiac devices, escalating intravenous drug use, and the high incidence of healthcare associated infections with antibiotic resistant microorganisms. From a clinical standpoint, SE can present at any time during the course of IE and may even be the initial presenting sign. SE may affect virtually any location in the human body, but some organs (e.g., liver, spleen, brain) and anatomic regions (e.g., lower extremity) tend to be more frequently involved. The most important aspect of management involves prompt recognition and proactive therapeutic approach. Given the broad spectrum of clinical presentations, symptoms and complications, SE can be challenging to diagnose and treat. Following the identification of SE, appropriate antibiotic coverage should be immediately instituted followed by supportive and/or interventional management, depending on the severity of presentation and the associated complications. In this chapter we explore the pathophysiology, anatomic origins, diagnostic tools, therapeutic measures, and new developments in SE, focusing predominantly on bacterial infections of cardiac origin.

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Clinical spectrum of septic pulmonary embolism and infarction

Cited by 78 publications

References 43 publications

Hemodialysis-Catheter Related Septic Pulmonary Emboli in the Absence of Endocarditis or Right Atrial Thrombus

Hemodialysis-Catheter Related Septic Pulmonary Emboli in the Absence of Endocarditis or Right Atrial Thrombus

A case of Sweet's syndrome following septic pulmonary emboli after high‐dose chemotherapy for advanced testicular cancer

Septic Embolism in Endocarditis: Anatomic and Pathophysiologic Considerations

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