Clinical Spectrum of HTLV-I in South Florida

Harrington, William J.; Ucar, Antonio; Gill, Parkash S.; Snodgrass, Susan; Sheremata, William A.; Cabral, Lisa; Rabin, Mark; Byrne, Gerald E.; Berger, Joseph R.; Voight, Walter; Kemper, Robert V.; Miller, G. B.; Whitcomb, Clarence C.; Greenberg, Alan E.; Byrnes, John; Poiesz, Bernard J.

doi:10.1097/00042560-199504120-00006

Cited by 31 publications

(20 citation statements)

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“…A search of the Ovid database for publications from the period of 1985-2005 yielded only 8 case reports of TSP/HAM among HIV-HTLV-coinfected individuals in the United States [35,[40][41][42]. The present report brings the total to 13.…”

Section: Discussionmentioning

confidence: 89%

“…TSP/HAM is rarely diagnosed outside of regions where HTLV-1 is endemic. The largest published study from the United States included a total of 63 patients with TSP/HAM in Florida [35]; however, the majority of the patients were originally residents of Haiti, Jamaica, or other Caribbean islands or were sex partners of individuals from these regions. Two of these patients were coinfected with HIV-1.…”

Section: Discussionmentioning

confidence: 99%

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Tropical Spastic Paraparesis/Human T Leukemia Virus Type 1--Associated Myelopathy in HIV Type 1--Coinfected Patients

Beilke

Japa

Moeller-Hadi

et al. 2005

Clinical Infectious Diseases

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Tropical Spastic Paraparesis/Human T Leukemia Virus Type 1--Associated Myelopathy in HIV Type 1--Coinfected Patients

Beilke

Japa

Moeller-Hadi

et al. 2005

Clinical Infectious Diseases

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“…3 South Florida is the continental US region most proximal to the Caribbean; therefore, HTLV-1-associated diseases, including ATLL and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), are commonly encountered in Miami, FL. 4,5 HTLV-1-related diseases may also affect US-born African Americans. 5 HTLV-1 establishes lifelong latency in human T cells.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology, clinical features, and outcome of HTLV-1–related ATLL in an area of prevalence in the United States

Pimentel²,

et al. 2018

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“…Many reports on cases or single institutional studies of ATLL in the United States have been published [25], but the true prevalence of the disease is unknown. Our data, taken from a large multi-institutional cohort, suggest that, among other-than-low-grade lymphomas, the prevalence rate of ATLL is around 4%, making this a rela-tively uncommon but not necessarily rare tumor.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of HTLV-I-associated T-cell lymphoma

Poiesz

Papsidero²,

Ehrlich

et al. 2000

Am. J. Hematol.

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In order to assess the prevalence rate of HTLV-1-associated T-cell lymphomas and human retrovirus infection in general, approximately 21,000 individuals representing various patient populations, retroviral risk groups, and blood donors were examined for HTLV-I, HTLV-II, HIV-1, or HIV-2 infection using serologic and PCR assays. The prevalence rates among volunteer blood donors were 0.02% and 0% for HTLV and HIV, respectively. Significantly increased HTLV prevalence rates were observed among paid blood donors, African American health care clinic patients, Amerindians, recipients of HTLV-positive cellular blood products, intravenous drug users, sexual contacts and family members of HTLV-positive people, and patients with primary thrombocytosis and other-than-low-grade non-Hodgkin's lymphoma (NHL). Among some of these groups there were significant differences in the prevalence of HTLV-I versus HTLV-II. The eight HTLV-positive NHL patients all had mature, high-grade, CD4+ T-cell lymphomas with clonally integrated HTLV-I, for a prevalence of 4% among other-than-low-grade NHL patients. Seven of the eight died from their disease within 2 years despite treatment. Interestingly, two groups at risk for HTLV infection, namely needle stick victims and recipients of HTLV-infected and/or pooled plasma products, showed no evidence for infection. Significantly increased HIV-1 prevalence was observed among paid blood donors, African Americans, homosexuals, female prostitutes, hemophiliacs, and other-than-low-grade NHL patients. Only one patient was infected with HIV-2. Of the nine HIV-positive, other-than-low-grade NHL patients, seven HIV-1 positives had B-cell lymphomas, one HIV-1 positive had an HTLV-I-positive CD4+ T-cell lymphoma, and one infected with HIV-2 had a CD4+ T-cell lymphoma that was HTLV negative. The data indicate that HTLV-I lymphoma, while uncommon, is not necessarily rare among other-than-low-grade NHL cases in the United States and, given its poor prognosis, should probably be studied separately in clinical trials.

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Clinical Spectrum of HTLV-I in South Florida

Cited by 31 publications

References 0 publications

Tropical Spastic Paraparesis/Human T Leukemia Virus Type 1--Associated Myelopathy in HIV Type 1--Coinfected Patients

Tropical Spastic Paraparesis/Human T Leukemia Virus Type 1--Associated Myelopathy in HIV Type 1--Coinfected Patients

Epidemiology, clinical features, and outcome of HTLV-1–related ATLL in an area of prevalence in the United States

Prevalence of HTLV-I-associated T-cell lymphoma

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