Clinical spectrum of herpes zoster in HIV infected versus non HIV infected patients in Benin City, Nigeria

Herpes zoster: clinical, therapeutic, and outcome aspects among HIV-infected patients in Yaoundé, Cameroon

“…This can be explained by a feminization of the HIV pandemic. The mean age of 39.7 years approaches what was found elsewhere (35 years) [1,10]. Similarly, the most represented age group (25-44 years) was also reported by Abdelmalek et al in Tunisia [1].…”

“…Concurring these results, Onumu et al found a female predominance in their Nigerian study, though at lower proportions (male/female sex ratio 0.74/1) [10]. This can be explained by a feminization of the HIV pandemic.…”

Robust gene expression changes in the ganglia following subclinical reactivation in rhesus macaques infected with simian varicella virus

“…These observations are in line with clinical studies that have indicated a critical role for CD4 T cells in prevention of VZV reactivation. Specifically, HZ is more prevalent in HIV+ patients (Onunu and Uhunmwangho, 2004). Furthermore, rapid recovery of CD4 T cells, but not CD8 T cells, after stem cell transplants is associated with reduced rates of cytomegalovirus reactivation (Drylewicz et al , 2016).…”

IE63-specific T-cell responses associate with control of subclinical varicella zoster virus reactivation in individuals with malignancies

“…Malignancy is associated with reactivation of chronic persistent viruses such as varicella zoster virus (VZV) (Whiteside, 2006), causing significant morbidity and mortality (Wade, 2006). Herpes zoster is more common in patients with malignancies (Schmader, 2001;Sorensen et al, 2004) and may lead to severe disease with multi-dermatomal involvement and visceral dissemination, which can be lethal (Gallagher and Merigan, 1979;Onunu and Uhunmwangho, 2004;Hackanson et al, 2005;Graue et al, 2006). However, apart from clinically apparent VZV reactivation, subclinical reactivation has also been reported in both immunocompetent and immunosuppressed individuals (Schunemann et al, 1998;Quinlivan et al, 2007).…”