Clinical spectrum of cryptogenic organising pneumonitis.

Bellomo, Rinaldo; Finlay, Moira; McLaughlin, Paul; Tai, E.

doi:10.1136/thx.46.8.554

Cited by 45 publications

(34 citation statements)

References 5 publications

(1 reference statement)

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“…The chest radiography varies depending on initial clinical manifestations [11]. Patients with a preceding URTI have patchy, mixed alveolar-interstitial infiltrates, often with a bilateral peripheral predominance and a migratory pattern [3, 4, 11, 12]. Our results confirm that bilateral alveolar and/or interstitial infiltrates are the most commonly seen radiographic findings.…”

Section: Discussionsupporting

confidence: 79%

“…The second pattern simulates idiopathic pulmonary fibrosis (IPF) but progresses over a shorter period. The third pattern develops rapidly with acute presentation [4, 7, 11]. The clinical findings of our patients were consistent with these patterns.…”

Section: Discussionsupporting

confidence: 74%

“…In the BOOP syndrome, three clinical patterns are recognized [11]. The first pattern is the most common and occurs in patients with a preceding upper respiratory tract infection (URTI) that proceeds to cough and progressive dyspnea after several weeks or months.…”

Section: Discussionmentioning

confidence: 99%

“…Plain chest radiography remains the first diagnostic approach to patients with BOOP but has limited diagnostic sensitivity and specificity as in the other diffuse infiltrative lung diseases [21]. The chest radiography varies depending on initial clinical manifestations [11]. Patients with a preceding URTI have patchy, mixed alveolar-interstitial infiltrates, often with a bilateral peripheral predominance and a migratory pattern [3, 4, 11, 12].…”

Section: Discussionmentioning

confidence: 99%

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Bronchiolitis obliterans Organizing Pneumonia

Oymak

Demirbaş

Mavili³

et al. 2005

Respiration

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Background: Bronchiolitis obliterans organizing pneumonia (BOOP) may be classified as cryptogenic (idiopathic) and secondary. There are no clear clinical and radiological features distinguishing between idiopathic and secondary BOOP. Objectives: To analyze the etiologic factors, clinical and radiological features, diagnostic approach and response to therapy at onset and outcome in subjects with BOOP. Methods: The medical files of Erciyes University Hospital from 1995 to 2003 were retrospectively reviewed. Patients with biopsy-proven BOOP were selected for evaluation. The etiology and initial features of BOOP, treatment, resolution, relapse, and survival were obtained from medical records, and a follow-up patient questionnaire. Results: We have diagnosed 26 cases (13 males /13 females) with BOOP syndrome (mean age 54 ± 15 years, range 14–93). More than half the patients (58%) were classified as idiopathic BOOP. Patients presented with cough (92%), dyspnea (70%), pleuritic chest pain, hemoptysis and fever (50%). The biopsy specimens had been obtained by transbronchial and/or transthoracic lung biopsy in 18 cases (69%). At radiological evaluation, there were bilateral patchy alveolar and/or interstitial infiltrates in 16 patients (62%), and solitary pneumonic involvement in 10 patients (38%). Three patients recovered spontaneously, 5 remained cured after resection of the focal lesion. Corticosteroid therapy was given in 17 patients (65%). Apart from four patients who died (death was attributable to BOOP in only 1 patient) and three patients who relapsed, the prognosis was good in all patients. Conclusions: The etiology of BOOP is usually idiopathic. We observed that hemoptysis and pleuritic chest pain were a relatively frequent symptom in BOOP in the present series, in contrast to previous observations. The diversity of radiological and clinical presentations including hemotysis and pleuritic chest pain should prompt consideration of the diagnosis in patients with persisting pulmonary symptoms and radiological findings.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Bronchiolitis obliterans Organizing Pneumonia

Oymak

Demirbaş

Mavili³

et al. 2005

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“…Nessa série, os pacientes com consolidação úni-ca apresentaram hemoptise mais freqüentemente, associação não encontrada em nossos casos, mas as lesões localizadas também predominaram nos lobos superiores. Em série de seis casos descritos como idiopáticos, Bellomo et al (11) igualmente encontraram apresentações clíni-cas e radiológicas diversas, com apresentações radiológi-cas localizadas. Em um caso, entretanto, o paciente estava usando amiodarona, uma possível associação.…”

Section: Discussionunclassified

O espectro clínico e radiológico da pneumonia em organização: análise retrospectiva de 38 casos

et al. 2002

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A pneumonia em organização, acompanhada ou não de bronquiolite obliterante, é uma condição anatomopatológica pulmonar específica com uma grande variedade de apresentações clínicas e radiológicas. A pneumonia em organização pode ser idiopática ou secundária a várias doenças, incluindo infecções e drogas. Objetivos: Descrever as manifestações clínicas, dados radiológicos e espirométricos de pacientes com pneumonia em organização. Métodos: Análise retrospectiva de pacientes com o diagnóstico de pneumonia em organização. Resultados: 38 pacientes foram incluídos na análise. Quatorze apresentavam também condições clínicas relacionadas à pneumonia em organização, e estes mais freqüentemente apresentaram infiltração pulmonar difusa (três de quatro casos) e bronquiolite obliterante associada (57% vs. 20%, p = 0,05). Dos 13 pacientes com bronquiolite obliterante associada apenas um era assintomático e dois apresentavam lesões localizadas (15%). De oito pacientes assintomáticos com lesões localizadas, nenhum possuía bronquiolite obliterante associada, e a apresentação radiológica freqüentemente mimetizou carcinoma brônquico. A espirometria de modo geral não contribuiu sobremaneira para o diagnóstico, provavelmente devido à alta prevalência de tabagismo na amostra. Conclusões: A pneumonia em organização possui apresentação clínica e radiológica variada. Fatores que sugerem a ausência de bronquiolite obliterante são a ausência de sintomas e lesões radiológicas localizadas, e esta forma da doença mais freqüentemente deve ser diferenciada de carcinoma brônquico na prática clínica. Doutor em Pneumologia pela UFRGS. Médico Pneumologista do Pavilhão Pereira Filho (ISCMPA). Professor da FEEVALE (RS).Endereço para correspondência -Adalberto Sperb Rubin, Rua Almirante Abreu, 246/402 -90420-010 -Porto Alegre, RS. E-mail: arubin@terra.com.brRecebido para publicação em 4/3/02. Aprovado, após revisão, em 18/8/02.

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Organizing pneumonia. Features and prognosis of cryptogenic, secondary, and focal variants

Lohr

Boland²,

Douglas³

et al. 1997

Archives of Internal Medicine

141

198

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Clinical classification of OP is useful to predict clinical course and outcome. Cryptogenic OP most often was a symptomatic bilateral lung process that had an overall favorable prognosis with prolonged corticosteroid therapy. Patients with secondary OP had a high mortality rate when the disease was associated with predisposing conditions or drugs. Patients with asymptomatic focal OP had an excellent prognosis.

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Clinical spectrum of cryptogenic organising pneumonitis.

Cited by 45 publications

References 5 publications

Bronchiolitis obliterans Organizing Pneumonia

Bronchiolitis obliterans Organizing Pneumonia

O espectro clínico e radiológico da pneumonia em organização: análise retrospectiva de 38 casos

Organizing pneumonia. Features and prognosis of cryptogenic, secondary, and focal variants

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