Clinical spectrum of chronic acquired demyelinating polyneuropathies

Abstract

A number of presentations of chronic demyelinating polyneuropathy have been identified, each distinguished by its phenotypic pattern. In addition to classic chronic inflammatory demyelinating polyneuropathy (CIDP), which is characterized clinically by symmetric proximal and distal weakness and sensory loss, several regional variants can be recognized: multifocal motor neuropathy (MMN: asymmetric and pure motor), multifocal acquired demyelinating sensory and motor (MADSAM) neuropathy (asymmetric, sensory, and motor), and distal acquired demyelinating symmetric (DADS) neuropathy (symmetric, distal, sensory, and motor). There are also temporal, pathological, and disease‐associated variants. This review describes a clinical scheme for approaching the chronic acquired demyelinating polyneuropathies that leads to a rational use of supportive laboratory studies and treatment options. In addition, we propose new diagnostic criteria for CIDP that more accurately reflect current clinical practice. © 2001 John Wiley & Sons, Inc. Muscle Nerve 24: 311–324, 2001

Effective treatment with intravenous immunoglobulins reduces autoreactive T-cell response in patients with CIDP

“…It has become evident that CIDP is not a homogeneous disorder but consists of several subtypes responding differentially to the various therapeutic options 25 26. Therefore, predictive biomarkers might be helpful for the selection of optimal initial treatment.…”

Profile and outcome of non-traumatic paraplegia in Kano, northwestern Nigeria

“…MRI was said to be suggestive in the presence of a hyperintense spinal cord signal change in T2-weighted images which may extend over 3-4 vertebral segments or hyperintensity in the central two-thirds of spinal cord with a central dot. [3][4][5] All the patients with suspected spinal cord disease (86 patients) had spinal X-ray. Viral studies, nerve conduction test, electromyography (EMG), CSF electrophoresis, etc.…”

MRI biomarkers of proximal nerve injury in CIDP

“…Proximal nerve injury has been recognized for a long time as a characteristic feature of CIDP, in contrast to many other neuropathies 8, 9, 10. However, the assessment of proximal nerve injury is hampered due to the limited accessibility of proximal nerves by standard nerve conduction studies.…”