2020
DOI: 10.4103/ijo.ijo_1375_19
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Clinical spectrum and management outcomes of Langerhans cell histiocytosis of the orbit

Abstract: Purpose: To describe the clinical spectrum and management outcomes of Langerhans cell histiocytosis (LCH) involving the orbit. Methods: Retrospective review of patients with orbital LCH presenting at the Sankara Nethralaya, Chennai, India, over the past 15 years. Demographic details, presenting features, radiology, histopathology, immunohistochemistry, and management outcomes were analyzed. Results: Nine patients were reviewed. The mean age o… Show more

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Cited by 7 publications
(19 citation statements)
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“…Literature review in PubMed yielded 68 results using the terms “langerhans cell histiocytosis and orbit” of which there are 15 applicable results outlined below. There were no complications with treatment 1,9–22 …”
Section: Discussionmentioning
confidence: 98%
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“…Literature review in PubMed yielded 68 results using the terms “langerhans cell histiocytosis and orbit” of which there are 15 applicable results outlined below. There were no complications with treatment 1,9–22 …”
Section: Discussionmentioning
confidence: 98%
“…The presence of langerin (CD207+) or cluster of differentiation 1a (CD1a) on immunohistochemistry or Birbeck granules on electron microscopy are specific for a definitive diagnosis of LCH 1,6 . The presence of S‐100, adenosine deaminase, alpha‐mannosidase, and peanut lectin binding are also common markers and two or more of these markers meet criteria from the International Histiocyte Society for a diagnosis of LCH 1 . Langerhans cell histiocytosis preferentially affects the bone, skin, lungs, and pituitary gland and can have variable presentation 14 .…”
Section: Discussionmentioning
confidence: 99%
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