Clinical signs of normal plasma volume expansion during pregnancy

Goodlin, Robert C.; Dobry, Charles A.; Anderson, Joseph C.; Woods, Ralph E.; Quaife, Merton A.

doi:10.1016/0002-9378(83)90856-6

Cited by 73 publications

(27 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5 Several studies in sub-Saharan Africa found an increased risk of LBW associated with maternal anemia 31 or severe anemia, 32 but this association was not consistent in the literature. 28 Physiological plasma volume expansion might be necessary and even beneficial during pregnancy, 33 but, as we found, severe anemia might have adverse effects as found by others. [34][35][36][37] We found an association between severe anemia and LBW when assessing Hb in the third trimester of pregnancy.…”

Section: Discussionsupporting

confidence: 64%

Maternal Anemia in Benin: Prevalence, Risk Factors, and Association with Low Birth Weight

Bodeau-Livinec¹,

Briand²,

Berger³

et al. 2011

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 64%

Maternal Anemia in Benin: Prevalence, Risk Factors, and Association with Low Birth Weight

Bodeau-Livinec¹,

Briand²,

Berger³

et al. 2011

The American Society of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…Only one author has previously reported a reduction in plasma volume in normotensive gravidas with FGR [ 12], However, it is not well defined if those cases corre sponded to idiopathic FGR, as in the present study, or if they also included FGR associated with various maternal conditions.…”

Section: Discussioncontrasting

confidence: 48%

Maternal Hemodynamic Adjustments in Idiopathic Fetal Growth Retardation

Rosso

Donoso

Braun

et al. 1993

Gynecol Obstet Invest

View full text Add to dashboard Cite

The hemodynamic characteristics of 11 normotensive gravidas with idiopathic fetal growth retardation (FGR), were compared with 11 controls of similar age, parity and body size. At weeks 36–38 of gestation, plasma volume was 3,161 ± 121 ml in controls and 2,624 ± 95 ml in the FGR group (p < 0.003); cardiac output (CO) was 6,191 ± 132 ml/min in controls and 5,483 ± 186 ml/min in the FGR group (p < 0.01). Total peripheral vascular resistance (TPVR) was lower in controls than in FGR (1,031 ± 33 vs. 1,306 ± 62 dyn/s/cm⁵; p < 0.001). Birth weight was correlated with both plasma volume (r = 0.61; p < 0.01) and CO (r = 0.53; p < 0.02) and inversely correlated with TPVR (r = ––0.69; p < 0.001). These results are in line with the hypothesis that a reduced plasma volume leads to a lower CO and, secondarily, to reduced uterine blood flow and FGR.

show abstract

“…In addition, failure of plasma volume expansion (or high Hgb) was associated with increased risk of fetal growth restriction. [30][31][32][33] Therefore, the plasma volume expansion and consequent "anemia" are associated with fewer low-birth-weight and preterm-birth deliveries.…”

Section: Discussionmentioning

confidence: 99%

Anemia During Pregnancy and Birth Outcome: A Meta-Analysis

Xiong¹,

Buekens²,

Alexander³

et al. 2000

Amer J Perinatol

161

114

View full text Add to dashboard Cite

To determine the relationship between maternal anemia [hemoglobin (Hgb) < 10-11 g/dL] and various birth outcomes, a meta-analysis was conducted based on published literature identified by MEDLINE and manual search from 1966 through 1999. Odds ratios (OR) from selected studies were pooled according to the gestational age at anemia diagnosis. The meta-analysis shows that maternal anemia during early pregnancy was associated with slightly increased preterm birth [pooled adjusted OR (aOR): 1.32, 95% confidence interval (CI): 1.01-1.74], and nonstatistically significant increased low birth weight [pooled aOR: 1.39 (0.70-2.74)], and was not associated with fetal growth restriction [pooled aOR: 1.01 (0.73-1.38)]. However, there was a nonstatistically significant inverse relationship between anemia during late pregnancy and preterm birth [pooled aOR: 0.92 (0.54-1.84)] and low birth weight [pooled aOR: 0.80 (0.64-1.00)]. Anemia was not statistically significantly associated with hypertensive disorders of pregnancy regardless of stage of pregnancy [pooled OR: 0.80 (0.53-1.20)]. The relationship between anemia and perinatal mortality was inconclusive. A few studies indicated that severe maternal anemia (Hgb < 8-8.5 g/dL) was associated with increased risk of poor outcomes. We conclude that early pregnancy anemia is associated with slightly increased risk of preterm birth. The trend toward an inverse association of anemia determined during late pregnancy with preterm birth and low birth weight may reflect the benefit of plasma volume expansion.

show abstract

Clinical signs of normal plasma volume expansion during pregnancy

Cited by 73 publications

References 7 publications

Maternal Anemia in Benin: Prevalence, Risk Factors, and Association with Low Birth Weight

Maternal Anemia in Benin: Prevalence, Risk Factors, and Association with Low Birth Weight

Maternal Hemodynamic Adjustments in Idiopathic Fetal Growth Retardation

Anemia During Pregnancy and Birth Outcome: A Meta-Analysis

Contact Info

Product

Resources

About