Clinical significance of Vimentin Antisense RNA 1 and its correlation with other epithelial to mesenchymal transition markers in oral cancers

Bozgeyik, Esra; Eğe, Bilal; Koparal, Mehtap

doi:10.1016/j.prp.2022.153807

Cited by 6 publications

(9 citation statements)

References 23 publications

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“…Interference with LINC01426 expression reduces the proliferation and metastatic capacity of LUAD H1299 and PC9 cells [15] . VIM-AS1 has been shown to be associated with cancer metastasis and poor patient prognosis [7][8][9][10][16][17][18] . For example, VIM-AS1 expression levels are signi cantly downregulated in breast cancer tissues.…”

Section: Discussionmentioning

confidence: 99%

IncRNA VIM-AS1 expression is positively correlated with the prognosis and immune infiltration in lung adenocarcinoma

Kang

Abudurufu

Zhang

et al. 2022

Preprint

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BackgroundStudies have reported that Long Non-coding RNA Vimentin antisense RNA1(VIM-AS1) is related to progression and prognosis in several cancers. Although the relationship between VIM-AS1 and the clinical features of lung adenocarcinoma has been described, their studies are incomplete. Therefore, a comprehensive analysis was performed to identify the role and potential clinical value of VIM-AS1 in LUAD progression.MethodsThe expression of VIM-AS1 in LUAD was identified based on Cancer Genome Atlas database (TCGA) and genotypic tissue expression (GTEx). Survival analysis and COX regression analysis were performed to evaluate the clinical value of VIM-AS1 in the prognosis of LUAD patients, and to construct a prognostic nomogram. Correlation and COX regression analysis were performed to filter prognosis-related VIM-AS1 co-expression genes, and to construct the correlation column chart and the prognostic risk model. Correlation analysis was also used to explore the relationship between VIM-ASI expression and LUAD immune microenvironment.ResultsVIM-AS1 expression levels were significantly downregulated in LUAD tissues and significantly associated with short OS, DSS, significant PFI, late T and pathological staging, lymph node metastasis, gender male and complete resection in LUAD patients. Decreased expression of VIM-AS1 was an independent risk factor for poor prognosis in LUAD patients. VIM-AS1 co-expressed genes SLC15A2, ZNF56, FAM76A, GNG7, UCK2, and ADIPOR2 were significantly associated with OS, DSS, and PFI in LUAD patients. The nomogram and risk models constructed based on VIM- AS1 co-expressed genes were associated with the prognosis of LUAD patients. K-M survival analysis showed that high-risk patients were significantly associated with short OS, DSS, and PFI in LUAD patients. VIM- AS1 expression was related to the estimate, immune and stromal scores, and highly associated with immune cells -TFH, Th1 cells, T cells, Tcm, B cells, T helper cells, cytotoxic cells, macrophages, pDC, iDC, aDC, mast cells, DC, Tem, NK CD56dim cells, Tgd and Th2 cells, and significantly correlated with levels of immune cell markers HLA-DPB1, HLA-DRA, CCR7, and other markers.ConclusionVIM-AS1 was significantly downregulated in LUAD tissues, which was significantly associated with poor prognosis and immune microenvironment in LUAD patients. The nomogram and risk models of VIM-AS1 were expected to be tools to assess the prognosis of LUAD patients.

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Section: Discussionmentioning

confidence: 99%

IncRNA VIM-AS1 expression is positively correlated with the prognosis and immune infiltration in lung adenocarcinoma

Kang

Abudurufu

Zhang

et al. 2022

Preprint

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“…Accordingly, the expression of E-cadherin exhibited an opposite trend, being downregulated in tumor samples. The higher expression of VIM-AS1 was also associated with an advanced clinical stage and the presence of lymph node metastasis [60] . Other crucial EMT-related ncNAT is ZE2-NAT ( ZEB2 natural antisense transcript), which was shown to be important for the maintenance of 5′-UTR ZEB2 intron through direct overlapping with the 5′ splice site in the intron [61] .…”

Section: Selected Cancer-related Ncnatsmentioning

confidence: 93%

Non-coding antisense transcripts: fine regulation of gene expression in cancer

Santos

Capela²,

Mateus³

et al. 2022

Computational and Structural Biotechnology Journal

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“…Another lncRNA downregulated in T2D patients (vs. euglycemic individuals) is Vimentin Antisense RNA 1 ( VIM-AS1 ); [ 161 ]. VIM-AS1 is located on chromosomal region 10p13 and transcribed from the opposite strand of the VIM gene, which is a positive regulator [ 162 ]. Interestingly, VIM-AS1 is strongly downregulated in T2D patients with DR compared to T2D patients without complications [ 161 ].…”

Section: Long Non-coding Rnas With Reduced Expression In Diabetic Ret...mentioning

confidence: 99%

Diabetic Retinopathy: Are lncRNAs New Molecular Players and Targets?

et al. 2022

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The growing incidence of diabetes mellitus worldwide implies the increasing prevalence of several related macro- (e.g., hypertension and atherosclerosis) and micro-vascular (e.g., nephropathy and retinopathy) complications. Notably, diabetic retinopathy (DR) is the leading cause of blindness in older diabetic patients and can occur with different degrees of severity. Chronic hyperglycemia is the main determinant of the functional damage of retinal cells. The oxidative stress, inflammatory factors and vascular endothelial growth factor signaling have been widely reported as contributors of DR onset and progression, and an emerging role has been described for different classes of non-coding RNA, including several long non-coding RNAs (lncRNAs). Here, we report the main results of all research articles (i.e., 150) listed on PubMed database from 2014 to 2022 regarding the putative role of lncRNAs in DR, including small nucleolar RNA host genes (SNHGs). Particularly, in this review we describe all lncRNAs and SNHGs with altered expression in DR and related contexts, discussing their association with DR outcomes, their mechanism of action related to DR, the molecular/functional effects, as well as the biological and experimental contexts. Thus, herein we provide an overview of the current state of knowledge regarding the putative involvement of 50 lncRNAs and SNHGs in the pathogenesis of DR, highlighting their potential as therapeutic targets or biomarkers for improving the clinical management of DR.

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Clinical significance of Vimentin Antisense RNA 1 and its correlation with other epithelial to mesenchymal transition markers in oral cancers

Cited by 6 publications

References 23 publications

IncRNA VIM-AS1 expression is positively correlated with the prognosis and immune infiltration in lung adenocarcinoma

IncRNA VIM-AS1 expression is positively correlated with the prognosis and immune infiltration in lung adenocarcinoma

Non-coding antisense transcripts: fine regulation of gene expression in cancer

Diabetic Retinopathy: Are lncRNAs New Molecular Players and Targets?

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