Clinical significance of urinary liver-type fatty acid-binding protein as a predictor of ESRD and CVD in patients with CKD

Matsui, Katsuomi; Kamijo‐Ikemori, Atsuko; Imai, Naohiko; Sugaya, Takeshi; Yasuda, Takashi; Tatsunami, Shinobu; Toyama, Tadashi; Shimizu, Miho; Furuichi, Kengo; Wada, Takashi; Shibagaki, Yugo; Kimura, Kenjiro

doi:10.1007/s10157-015-1144-9

Cited by 40 publications

(32 citation statements)

References 34 publications

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“…CVD is the critical cause of mortality in PD and HD patients. 8 Extracellular fluid volume overload and hypertension are the most common pathogenesis which result in myocardial hypertrophy. 9 Calcium concentration was reported to be an important factor in the development of CVD.…”

Section: Discussionmentioning

confidence: 99%

The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients

Wang

Wen

et al. 2016

Renal Failure

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Left ventricular (LV) diastolic function was found to be a significant predictor of cardiovascular events and general mortality in dialysis. Studies have indicated that dialysate calcium concentrations were significantly associated with cardiac function. However, the relationship between low calcium dialysate and LV diastolic function has not been clear. The aim of this study was to investigate the influence of low calcium dialysate on cardiac function in peritoneal dialysis (PD) patients. A total of 60 PD patients were enrolled in this study, with a calcium content of the PD solution of 1.25 mmol/L in 30 patients (low-calcium group) and 1.75 mmol/L in 30 patients (standard-calcium group). Standard M-mode and two-dimensional ultrasound measurements were applied to detect the cardiac function. After 12-month follow-up, we found no significant difference in blood pressure, calcium, phosphorus, parathyroid hormone (PTH), etc., between the two groups. Residual renal function (RRF), which is associated with LV cardiac function, was significantly decreased in the standard-calcium group compared with the low-calcium group (5.64 ± 3.23 vs. 9.38 ± 3.17, p ¼ .001). Compared with the low-calcium group, E max (peak early diastolic velocity) and A max (peak late diastolic velocity) were significantly decreased (p < .05), whereas myocardial performance index (MPI) was obviously increased in standard-calcium group (9.69 ± 2.71 vs. 7.75 ± 0.93, p < .05). In conclusion, our data suggest that low calcium dialysate treatment is significantly associated with better LV diastolic function. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients

Wang

Wen

et al. 2016

Renal Failure

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“…To precisely evaluate the degree of renal injury using the marker urinary liver-type fatty acid-binding protein (L-FABP) (11), human L-FABP chromosomal transgenic (Tg) mice (12) in which human L-FABP was expressed in proximal tubules of the cortex were used, because L-FABP is not expressed in mouse kidneys (37). Because urinary L-FABP accurately reflects the degree of oxidative stress, peritubular blood flow, and tubulointerstitial damage (14 -16), it is a novel tubular marker to predict renal prognosis in CKD (11,13,19) or for early detection of diabetic nephropathy (1,16,27) and acute kidney disease (acute kidney injury) (20,32,39) in clinical practice.…”

mentioning

confidence: 99%

Renoprotective effect of the xanthine oxidoreductase inhibitor topiroxostat on adenine-induced renal injury

Kamijo‐Ikemori

Sugaya

Hibi³

et al. 2016

American Journal of Physiology-Renal Physiology

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The aim of the present study was to reveal the effect of a xanthine oxidoreductase (XOR) inhibitor, topiroxostat (Top), compared with another inhibitor, febuxostat (Feb), in an adenine-induced renal injury model. We used human liver-type fatty acid-binding protein (L-FABP) chromosomal transgenic mice, and urinary L-FABP, a biomarker of tubulointerstitial damage, was used to evaluate tubulointerstitial damage. Male transgenic mice (n = 24) were fed a 0.2% (wt/wt) adenine-containing diet. Two weeks after the start of this diet, renal dysfunction was confirmed, and the mice were divided into the following four groups: the adenine group was given only the diet containing adenine, and the Feb, high-dose Top (Top-H), and low-dose Top (Top-L) groups were given diets containing Feb (3 mg/kg), Top-H (3 mg/kg), and Top-L (1 mg/kg) in addition to adenine for another 2 wk. After withdrawal of the adenine diet, each medication was continued for 2 wk. Serum creatinine levels, the degree of macrophage infiltration, tubulointerstitial damage, renal fibrosis, urinary 15-F2t-isoprostane levels, and renal XOR activity were significantly attenuated in the kidneys of the Feb, Top-L, and Top-H groups compared with the adenine group. Serum creatinine levels in the Top-L and Top-H groups as well as renal XOR in the Top-H group were significantly lower than those in the Feb group. Urinary excretion of L-FABP in both the Top-H and Top-L groups was significantly lower than in the adenine and Feb groups. In conclusion, Top attenuated renal damage in an adenine-induced renal injury model.

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“…b Correlation between ischemic time and urinary L-FABP. R indicates correlation coefficient [36] disease (CKD) [53] or those who have undergone cardiac catheterization [54,55] or renal transplantation [56,57]. Clinical prospective observation studies to predict mortality in sepsis using urinary L-FABP have been conducted with both adult patients and pediatric patients (Table 3) [27,28].…”

Section: Predicting Poor Outcomesmentioning

confidence: 99%

“…It is important to measure the higher range near 100 ng/ml for ICU patients because it was suggested that upper levels of urinary L-FABP than 100 μg/g Cr may be specific to septic shock [25]. Additionally, it is also important to measure the range near 12.5 ng/ml for CKD patients because it was reported that levels of urinary L-FABP above the upper limit of the reference value (8.4 μg/g Cr [6]) are a risk factor for the progression to ESRD, the onset of cardiovascular disease CVD, and death [53]. When we reanalyzed reference value to L-FABP concentration, the reference value which converted to L-FABP concentration was 10.1 ng/ml.…”

Section: Clinical Significance Of the Poc Assay For Urinary L-fabpmentioning

confidence: 99%

Urinary excretion of liver-type fatty acid-binding protein reflects the severity of sepsis

et al. 2017

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Sepsis due to microbial invasion often causes multiple organ failure (MOF), including acute kidney injury (AKI), with high mortality rates in serious cases. Hence, there is an urgent need for diagnostic biomarkers that can be used to rapidly, accurately, and easily detect sepsis to identify the condition early and guide the selection of appropriate treatment. Liver-type fatty acid-binding protein (L-FABP), which localizes in renal proximal tubules, is excreted into the urine in response to oxidative stress-induced tubular injury. Because of this mechanism, L-FABP has been reported to be a useful urinary biomarker not only for renal disease but also for the severity of sepsis. Based on this concept, we developed a new L-FABP point-of-care (POC) assay kit that can be used to rapidly measure human L-FABP in the urine to further improve the usefulness of this biomarker in clinical settings. In this review, we describe the molecular mechanisms of L-FABP, its clinical usefulness, and the performance of the POC assay kit.

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Clinical significance of urinary liver-type fatty acid-binding protein as a predictor of ESRD and CVD in patients with CKD

Abstract: Urinary L-FABP may be a useful prognostic marker of progression to ESRD and the onset of CVD in patients with CKD.

Cited by 40 publications

References 34 publications

The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients

The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients

Renoprotective effect of the xanthine oxidoreductase inhibitor topiroxostat on adenine-induced renal injury

Urinary excretion of liver-type fatty acid-binding protein reflects the severity of sepsis

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