Clinical significance of transient receptor potential vanilloid 2 expression in human hepatocellular carcinoma

Liu, Guoxing; Xie, Chengzhi; Sun, Fadi; Xu, Xundi; Yang, Yaohui; Zhang, Tao; Deng, Yuansheng; Wang, Dianchen; Huang, Zhao; Li, Yang; Huang, Shengfu; Wang, Qunwei; Li, Guoli; Zhong, Di; Miao, Xiangshui

doi:10.1016/j.cancergencyto.2009.08.007

Cited by 53 publications

(36 citation statements)

References 31 publications

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“…Moreover, a role for TRPV2 in lysophospholipid‐mediated migration, extracellular matrix invasion and progression to androgen resistance of prostate cancer cells has been reported 26, 27. Finally, a clinicopathological significance of TRPV2 expression as prognostic marker in human hepatocellular carcinoma has been shown 28…”

mentioning

confidence: 95%

“…TRPV2 was found in neuronal and non‐neuronal tissues,15, 18, 22, 23 where its activity can be regulated by signaling events triggered by growth factors including the insulin growth factor‐I, the platelet‐derived growth factor and the neuropeptide head activator that can induce the translocation of TRPV2 channel from the intracellular compartments to the plasma membrane through phosphatidylinositol‐3 kinase (PI3‐kinase)‐dependent and ‐independent pathways 24, 25. Recent evidence indicates a specific role of TRPV2 in cancer 17, 26–28. In this regard, we have recently reported that TRPV2 negatively controls glioma cell survival and proliferation as well as resistance to Fas‐induced apoptosis in an extracellular signal‐regulated kinases‐dependent manner 17.…”

mentioning

confidence: 99%

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The transient receptor potential vanilloid‐2 cation channel impairs glioblastoma stem‐like cell proliferation and promotes differentiation

Morelli

Nabissi

Amantini

et al. 2012

Intl Journal of Cancer

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Malignant transformation of cells resulting from enhanced proliferation and aberrant differentiation is often accompanied by changes in transient receptor potential vanilloid (TRPV) channels expression. In gliomas, recent evidence indicates that TRPV type 2 (TRPV2) negatively controls glioma cell survival and proliferation. In addition, cannabinoids, the ligands of both cannabinoid and TRPV2 receptors, promote glioblastoma stem-like cells (GSCs) differentiation and inhibit gliomagenesis. Herein, we provide evidence on the expression of TRPV2 in human GSCs and that GSCs differentiation reduces nestin and progressively increases both the glial fibrillary acidic protein (GFAP) and TRPV2 expression. Therefore, we evaluated the role of TRPV2 cation channel in GSC lines differentiation. Treatment of GSC lines with the TRPV antagonist Ruthenium Red, with ethylene glycol-bis(2-aminoethylether)-N,N,N 0 ,N 0 -tetraacetic acid or knockdown of TRPV2 gene during differentiation, decreases GFAP and class III beta-tubulin (b III -tubulin) expression; conversely, phorbol-12-myristate-13-acetate stimulates GSCs proliferation, reduces TRPV2 expression and partially reverts astroglial differentiation. In addition, forced TRPV2 expression in GSC lines by stable TRPV2 transfection increases GFAP and b III -tubulin expression and parallelly reduces proliferation. Finally, TRPV2 overexpression inhibits GSCs proliferation in a xenograft mouse model, as shown by reduced tumor diameter and mitotic index, and promotes the differentiation of GSCs toward a more mature glial phenotype. Overall, our results demonstrate that TRPV2 promotes in vitro and in vivo GSCs differentiation and inhibits their proliferation. Better understanding of the molecular mechanisms that regulate the balance between proliferation and differentiation of GSCs would lead to more specific and efficacious pharmacological approaches.Malignant gliomas remain the most deadly human brain tumors with a poor prognosis despite years of research in antitumoral therapeutic strategies. A hallmark characteristic of gliomas is their molecular and cellular heterogeneity that is considered to be one of the reasons for their high malignancy and recurrence. 1,2 Neoplastic transformation of differentiated glial cells was for many years the most accepted hypothesis to explain the origin of gliomas 1,2 ; however, recent findings support the existence of a stem cell-derived origin for different types of cancers including brain tumors. 2,3 In particular,

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confidence: 95%

mentioning

confidence: 99%

The transient receptor potential vanilloid‐2 cation channel impairs glioblastoma stem‐like cell proliferation and promotes differentiation

Morelli

Nabissi

Amantini

et al. 2012

Intl Journal of Cancer

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“…TRPV2 protein is expressed in human hepatoblastoma (HepG2) cells (Vriens et al, 2004). TRPV2 was found to be more expressed at both the mRNA and protein levels in cirrhotic livers compared with chronic hepatitis, whereas it also occurred in moderately and well-differentiated tumors compared with that of poorly differentiated tumors (Liu et al, 2010). In hepatocellular carcinoma the increased expression of TRPV2 was identified in 16/55 (29%) cases.…”

Section: Expressionmentioning

confidence: 99%

“…Prognosis Quantitative RT-PCR and Western blotting analysis revealed that expression of TRPV2 at both the mRNA and protein levels were increased in cirrhotic livers compared with chronic hepatitis, whereas that also occurred in moderately and well-differentiated tumors compared with that of poorly differentiated tumors (Liu et al, 2010). Immunohistochemistry of the 55 human hepatocellular carcinoma samples showed that the expression of TRPV2 increased when going from normal liver or chronic hepatitis to cirrhosis.…”

Section: Liver Cancermentioning

confidence: 99%

TRPV2 (transient receptor potential cation channel, subfamily V, member 2)

Lehen’kyi¹,

Prevarskaya²

2012

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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“…Despite the discovery of several carcinogenetic pathways, the mechanisms of liver carcinogenesis still remain to be clarified. Further insight into the alterations for distinct molecular pathways during hepatocarcinogenesis could improve the screening and treatment of HCC patients …”

Section: Introductionmentioning

confidence: 99%

Differential expression analysis of Golgi apparatus proteomes in hepatocellular carcinomas and the surrounding liver tissues

Yang¹,

Luo

Li³

et al. 2013

Hepatology Research

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Clinical significance of transient receptor potential vanilloid 2 expression in human hepatocellular carcinoma

Cited by 53 publications

References 31 publications

The transient receptor potential vanilloid‐2 cation channel impairs glioblastoma stem‐like cell proliferation and promotes differentiation

The transient receptor potential vanilloid‐2 cation channel impairs glioblastoma stem‐like cell proliferation and promotes differentiation

TRPV2 (transient receptor potential cation channel, subfamily V, member 2)

Differential expression analysis of Golgi apparatus proteomes in hepatocellular carcinomas and the surrounding liver tissues

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