Clinical Significance of Toll-Like Receptor and Toll-Like Receptor Blocker

Choi, Jae Young; Song, Phil Hyun; Ko, Young Hwii

doi:10.14777/uti.2016.11.1.1

Cited by 2 publications

(6 citation statements)

References 45 publications

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“…TLR/4Myd88/NF-κB signaling pathway is used to activate nuclear factors, induce systemic immune response and mutually participate in the development of KOA. [8] In conclusion, the abnormal increase in the levels of TLR-4 and IL-1β in the serum and the joint fluid in KOA patients is closely associated with the development of the disease. These two indicators can not only be used to predict the occurrence of the disease, but also used to monitor the development degree of KOA.…”

Section: Discussionmentioning

confidence: 85%

“…; [19] 3) the reduction of the synthetic amount of proteoglycans and the increase of the amount of glucolysis lead to the degradation of cartilage matrix, accelerate the apoptosis of cartilage cells and mutually participate in the occurrence of KOA; [20] 4) enhancing the growth speed of B cells, inhibiting the expression of collagens in cartilage cells and performing a bone resorption function; [21] 5) accelerating the release of prostaglandin E2 in synovial tissues and cartilage tissues, and E2 can improve the effect of IL-1β on degrading the cartilage; [22] 6) improving the pro-inflammatory effect of the collagenases. [8] Pearson correlation analysis shows that the level of TLR-4 in the serum is positively correlated to the level of IL-1β in the serum (p < .05); the level of TLR-4 in the joint fluid is positively correlated to the level of IL-1β in the joint fluid (p < .05). It is indicated that TLR-4 is closely associated with IL-1β, and it is probably due to the high homology.…”

Section: Discussionmentioning

confidence: 99%

“…However, the specific pathogenesis remains to be studied. Some researches have shown that, [8] inflammatory reactions and immunological stress reactions are significant to the occurrence and development of KOA. Not only KOA is an inflammatory disease affecting all joints, but also autoimmune responses play an important role in the development of KOA.…”

Section: Discussionmentioning

confidence: 99%

“…[13] In 1985, Toll-like receptors were firstly found by Nusslein Volhard in drosophila embryos, and this type of receptors belongs to Type I transmembrane receptors, which can recognize exogenous ligands such as polysaccharide, bacterial lipoprotein and so on. [7][8][9] TLR-4, as an important member of Toll family, is considered as one of Type I transmembrane receptors, which is composed of intracellular domain, extracellular domain and transmembrane domain. It can participate in the development of multiple diseases by specifically activating autoimmune responses.…”

Section: Discussionmentioning

confidence: 99%

“…They probably participate in the pathological course of KOA. [8,9] It provides a new idea for the clinical exploration of the specific pathogenesis of KOA. By detecting the levels of TLR-4 and IL-1β in the serum and knee joint fluid and exploring their correlation, the research is designated to provide a theoretical basis for exploring the pathogenesis of KOA and the treatment methods.…”

Section: Introductionmentioning

confidence: 99%

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Expression changes and clinical significance of TLR-4 and IL-1β in serum and knee joint fluid of patients with knee osteoarthritis

Mao¹,

Zhu

Liu³

et al. 2020

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Objective: To investigate the expression changes and clinical significance of Toll-like receptor-4 (TLR-4) and interleukin-1β (IL-1β) in the serum and knee joint fluid in patients with knee osteoarthritis (KOA).Methods: From June 2017 to December 2018, 220 cases of patients with KOA who were admitted in Department of Orthopedics of the Third Affiliated Hospital of Inner Mongolia Medical University (“our hospital” for short) were selected as the observation group. According to the severity of KOA, they were divided into the mild subgroup (n = 98), the moderate subgroup (n = 80) and the severe subgroup (n = 42). In addition, 60 cases of volunteers who received the physical examination in Health Medical Center of our hospital were selected as the control group. The levels of TLR-4 and IL-1β in the serum and knee joint fluid were detected by enzyme-linked immunosorbent assay, in order to analyze the correlation of TLR-4 and IL-1β levels with the severity of KOA.Results: The levels of TLR-4 and IL-1β in the serum and knee joint fluid of the observation group were significantly higher than those of the control group, and the differences were statistically significant (all p < .05). The levels of TLR-4 and IL-1β in the serum and knee joint fluid of the severe subgroup were significantly higher than those of the mild subgroup and the moderate subgroup, and the levels of TLR-4 and IL-1β in the serum and knee joint fluid of the moderate subgroup were higher than those of the mild group. The differences were statistically significant (all p < .05). The levels of TLR-4 and IL-1β in the serum and knee joint fluid were positively correlated to the severity of KOA (r = .706, .729, .741, .715, all p < .05); in the serum, the level of TLR-4 was positively correlated to the level of IL-1 (r = .720, p < .05); in the joint fluid, the level of TLR-4 was positively correlated to the level of IL-1 (r = .736, p < .05).Conclusions: The levels of TLR-4 and IL-1β in the serum and knee joint fluid of KOA patients are abnormally increased, which is closely related with the severity of KOA. It can be used for clinical prediction, diagnosis and treatment of KOA.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression changes and clinical significance of TLR-4 and IL-1β in serum and knee joint fluid of patients with knee osteoarthritis

Mao¹,

Zhu

Liu³

et al. 2020

DCC

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Host-Pathogen Interactions in Urinary Tract Infections

Choi

Song

2019

Urogenit Tract Infect

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Urinary tract infections (UTIs) are classified by the host condition. Uncomplicated infections are caused most commonly by uropathogenic Escherichia coli (UPEC) and affect otherwise healthy people, whereas complicated infections are commonly caused by species, such as Proteus mirabilis, and affect patients with underlying difficulties, such as a urinary tract abnormality or catheterization. The outcome of infection caused by these bacteria is dictated by the immune response to the UTI and the host factors that influence the susceptibility to disease. This review focuses on the host pathogen interactions in UTI, including an identification of additional virulence factors and therapeutic or prophylactic targets, particularly by UPEC and P. mirabilis.

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Clinical Significance of Toll-Like Receptor and Toll-Like Receptor Blocker

Cited by 2 publications

References 45 publications

Expression changes and clinical significance of TLR-4 and IL-1β in serum and knee joint fluid of patients with knee osteoarthritis

Expression changes and clinical significance of TLR-4 and IL-1β in serum and knee joint fluid of patients with knee osteoarthritis

Host-Pathogen Interactions in Urinary Tract Infections

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