Clinical significance of the subsets of lymphocyte in the peripheral blood of the head and neck cancer patients.

Okamoto, Makito; Takahashi, Hiromi; Yao, Kazuo; Fujino, Akito; Ishii, Toyota; Harada, Kouichi; Yagi, Akira; Yagi, Kazunori; Furusawa, Shin; Furusawa, Ichi; Momiyama, Yasuhiro

doi:10.3950/jibiinkoka.88.443

Cited by 2 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They also reported that the CD4 ϩ SP T-cell subset decreased in association with lymphocytopenia, whereas the CD8 ϩ SP T-cell subset and the B-cell fraction remained unchanged even in tumor-bearing individuals and their descendants. Similar findings have been documented in patients with malignant tumor of the head and neck, 10 and there is a report that both Th1 function, which is involved in cellular immunity, and Th2 function, which is related to humoral immunity, are progressively depressed with progression of the tumor-bearing state. Thus, it appears likely that the B-cell function of antibody production and the cytotoxic function of CD8 ϩ SP T cells were not fully operating, and that the observed increases in the B-cell fraction and CD8 ϩ SP T-cell subset percentage were no more than apparent increases resulting from the marked decreases in the T-cell fraction and the CD4 ϩ SP T-cell subset percentage.…”

Section: Peripheral Blood Lymphocyte Subsetsmentioning

confidence: 51%

Lymphocyte changes in peripheral blood, spleen, and liver in DMBA-induced squamous cell carcinoma of mouse cheek skin

2004

View full text Add to dashboard Cite

The peripheral blood, spleen, and liver lymphocyte subsets of mice with experimental cheek skin carcinoma were determined. The carcinoma was induced by the topical application of 2% (w/v) 9,10-dimethyl-1,2-benzanthracene (DMBA) to cheek skin twice a week for 12 weeks, and it was examined macroscopically and histopathologically. The composition of lymphocyte subsets (T cells, B cells, CD4+ single-positive [SP] T cells, and CD8+SP T cells) in peripheral blood, spleen, and liver was determined by flow cytometry at 3-week intervals for up to 24 weeks. Spleens and livers were assessed by determining their content of natural killer (NK)T cells. The results showed histopathological progression of the skin lesions from papilloma to squamous cell carcinoma at week 12. Body weight was significantly reduced from weeks 15 to 24, and spleen weight was significantly increased at weeks 21 and 24, but liver weight was not significantly different from the control. The lymphocyte subset composition of peripheral blood showed significant elevation of T cells at weeks 6 and 9, followed by reduced levels at weeks 21 and 24, with significant reduction of B cells at weeks 6 and 9, followed by elevation at weeks 21 and 24. CD4+SP T-cell content was elevated at weeks 6, 9, and 12, and reduced at weeks 21 and 24. CD8+SP T-cell content was significantly reduced at weeks 6, 9, and 12, and elevated at weeks 21 and 24. The composition of the lymphocyte subsets in the spleen was similar to their composition in peripheral blood. The composition of both T and B cells in the liver was significantly different from that in the corresponding control group, but no significant differences were found in either CD4+SP or CD8+SP T cells. These findings revealed that the DMBA-induced cheek skin carcinoma in mice affected not only the lymphocyte subsets in peripheral blood, but the cells in the spleen and liver as well.

show abstract

Section: Peripheral Blood Lymphocyte Subsetsmentioning

confidence: 51%

Lymphocyte changes in peripheral blood, spleen, and liver in DMBA-induced squamous cell carcinoma of mouse cheek skin

2004

View full text Add to dashboard Cite

show abstract

Analysis of the Results of Combined Therapy for Maxillary Carcinoma

Sakata¹,

Aoki²,

Kiura³

et al. 1993

Cancer

View full text Add to dashboard Cite

Background. Maxillary sinus carcinomas usually are locally advanced. A wide variety of modalities, including surgery, radiation therapy, and intraarterial chemotherapy, alone or in combination, have been used. However, there is still much controversy with regard to the optimum treatment. Methods. From 1972 to 1986, 108 patients with squamous cell carcinoma of the maxillary sinus were treated at the Department of Radiology, University of Tokyo Hospital. From 1972 to 1974 (the first period), the treatment consisted of operation for reduction of tumor volume, daily cleaning of the maxillary antrum, 20 Gy of postoperative radiation therapy, and intraarterial infusion of 1500 mg of 5‐fluorouracil (5‐FU) and 3000 mig of 5‐bromodeoxyuridine (BUdR). From 1975 to 1979 (the second period), the radiation dose was reduced to 10 Gy, and intraarterial infusion of 5‐FU and BUdR was not performed. Surgery for reduction of tumor volume and daily cleaning of the antrum played a major role in this period. From 1980 to 1982 (the third period), daily cleaning of the antrum was not performed. Instead, the dose of radiation was increased to 50–60 Gy. From 1983 to 1986 (the fourth period), more extensive surgery to resect the tumor en bloc was introduced. The radiation dose was increased to 70 Gy. Intraarterial infusion of 3750 mg of 5‐FU and 120 mg of cisplatin also was administered. Results. The 5‐year survival rate was 46% in the first period, 24% in the second period, 7.2% in the third period, and 53% in the fourth period. In the third period, there were more cases in which death resulted from a cause other than local failure, such as distant metastasis, pneumonia, or secondary primary cancer. Since 1984, we planned treatment with computed tomography (CT) and used the linear accelerator with a multileaf collimator to treat patients with an irregular field of irradiation. These have made it possible to administer radiation therapy in doses as high as 70 Gy without severe complications and improve the survival rate, especially for T4 disease. Conclusions. Radiation plays an important role in sterilizing malignant cells that cannot be removed by operation. The dose of radiation should be determined according to the volume of residual tumor. Careful treatment planning is required to irradiate the tumor adequately and reduce complications.

show abstract

Clinical significance of the subsets of lymphocyte in the peripheral blood of the head and neck cancer patients.

Cited by 2 publications

References 2 publications

Lymphocyte changes in peripheral blood, spleen, and liver in DMBA-induced squamous cell carcinoma of mouse cheek skin

Lymphocyte changes in peripheral blood, spleen, and liver in DMBA-induced squamous cell carcinoma of mouse cheek skin

Analysis of the Results of Combined Therapy for Maxillary Carcinoma

Contact Info

Product

Resources

About