Clinical significance of the long‐term symptom‐modifying effects of glucosamine sulfate: Comment on the article by Brandt and Mazzuca

Bruyère, Olivier; Reginster, Jean‐Yves; Giacovelli, Giampaolo; Barbetta, Beatrice; Rovati, Lucio C.; Pavelka, Karel

doi:10.1002/art.21867

Cited by 6 publications

(4 citation statements)

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“…However, the baseline Lequesne index scores indicated at least moderate symptomatic disease severity in the GUIDE study (17), and the present results are therefore applicable to this subset of patients with knee OA. Conversely, previous long‐term trials have focused on the effects of glucosamine sulfate in patients with milder disease (4, 5, 44).…”

Section: Discussionmentioning

confidence: 99%

Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: A randomized, double‐blind, placebo‐controlled study using acetaminophen as a side comparator

Herrero‐Beaumont¹,

Ivorra²,

Trabado³

et al. 2007

Arthritis & Rheumatism

241

161

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Objective. To assess the effects of the prescription formulation of glucosamine sulfate (1,500 mg administered once daily) on the symptoms of knee osteoarthritis (OA) during a 6-month treatment course.Methods. Three hundred eighteen patients were enrolled in this randomized, placebo-controlled, doubleblind trial in which acetaminophen, the currently preferred medication for symptomatic treatment of OA, was used as a side comparator. Patients were randomly assigned to receive oral glucosamine sulfate 1,500 mg once daily (n ‫؍‬ 106), acetaminophen 3 gm/day ( n ‫؍‬ 108), or placebo (n ‫؍‬ 104). The primary efficacy outcome measure was the change in the Lequesne index after 6 months. Secondary parameters included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and response according to the Osteoarthritis Research Society International criteria. These outcome measures were assessed using an intentto-treat analysis.Results. At baseline, the study patients had moderately severe OA symptoms (mean Lequesne index ϳ11 points). Glucosamine sulfate was more effective than placebo in improving the Lequesne score, with a final decrease of 3.1 points, versus 1.9 with placebo (difference between glucosamine sulfate and placebo ؊1.2 [95% confidence interval ؊2.3, ؊0.8]) (P ‫؍‬ 0.032). The 2.7-point decrease with acetaminophen was not significantly different from that with placebo (difference ؊0.8 [95% confidence interval ؊1.9, 0.3]) (P ‫؍‬ 0.18). Similar results were observed for the WOMAC. There were more responders to glucosamine sulfate (39.6%) and acetaminophen (33.3%) than to placebo (21.2%) (P ‫؍‬ 0.004 and P ‫؍‬ 0.047, respectively, versus placebo). Safety was good, and was comparable among groups.Conclusion. The findings of this study indicate that glucosamine sulfate at the oral once-daily dosage of 1,500 mg is more effective than placebo in treating knee OA symptoms. Although acetaminophen also had a higher responder rate compared with placebo, it failed to show significant effects on the algofunctional indexes.ClinicalTrials.gov identifier: NCT00110474.

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Section: Discussionmentioning

confidence: 99%

Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: A randomized, double‐blind, placebo‐controlled study using acetaminophen as a side comparator

Herrero‐Beaumont¹,

Ivorra²,

Trabado³

et al. 2007

Arthritis & Rheumatism

241

161

View full text Add to dashboard Cite

show abstract

“…This symptom modification is sustained for years, and there is an intriguing suggestion of possible disease (structure) modification (5,6). These long-term effects are particularly relevant (7), given the chronic and progressive nature of this degenerative joint disease. Several reviews and meta-analyses have scrutinized the efficacy of glucosamine.…”

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confidence: 99%

The efficacy of glucosamine sulfate in osteoarthritis: Financial and nonfinancial conflict of interest

Reginster¹

2007

Arthritis & Rheumatism

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“…Other reports have questioned the significance of this symptom improvement [53]; however, this has been recently reassessed and found to be clinically relevant [54], although the effect size is small due to the mild symptom characteristics of the patients at enrolment.…”

Section: Figure 2 Mean Change In the Lequesne Index Score (In Pointsmentioning

confidence: 96%

Use of crystalline glucosamine sulfate in osteoarthritis

Herrero

Rovati²

2006

Future Rheumatology

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Clinical significance of the long‐term symptom‐modifying effects of glucosamine sulfate: Comment on the article by Brandt and Mazzuca

Cited by 6 publications

References 6 publications

Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: A randomized, double‐blind, placebo‐controlled study using acetaminophen as a side comparator

Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: A randomized, double‐blind, placebo‐controlled study using acetaminophen as a side comparator

The efficacy of glucosamine sulfate in osteoarthritis: Financial and nonfinancial conflict of interest

Use of crystalline glucosamine sulfate in osteoarthritis

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