Clinical significance of the diagnosis of low‐grade squamous intraepithelial lesion, cannot exclude high‐grade squamous intraepithelial lesion

Abstract

The similarity of histologic follow-up results between LSIL-H and ASC-H suggested that the management of women who have a diagnosis of LSIL-H should be similar to the management of women who have a diagnosis of ASC-H.

P53, bcl-2, and nm23 expressions in serous ovarian tumors: correlation with the clinical and histopathological parameters

“…We obtained similar values between aSC-H, and LSiL and HSiL as regards determining Cin2 or higher lesions of LSiL-aSC-H. Past studies have reported similar results (2,8,16 in conclusion, we believe that LSiL/aSC-H should be classified as a separate category as there is a high chance of defining the underlying Cin2 and that it should therefore be evaluated separately from LSiL. We found that LSiL/ aSC-H had a high risk of a Cin2 or higher neoplasia like aSC-H but that it had low risk for Cin3 in contrast.…”

“…This rate was higher than with LSiL (0%), aSC-H (8%) and HSiL (13%). Hang et al (18) and alsharif et al (8). have also reported that biopsies of patients diagnosed with LSiL/aSC-H have a higher rate of Cin2 diagnosis when found to have a Cin2 or higher lesion and LSiL/aSC-H probably indicates Cin2 as also reported by these authors.…”

“…The potential of LSiL/aSC-H to catch a Cin2 or higher lesion (45%) was especially consistent with some previous studies (3,6,16,17). The rate of finding a Cin2 or higher lesion in LSiL/aSC-H biopsies was slightly higher than aSC-H in some studies (4,6,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) and slightly lower in others (2,3,5,19).…”

“…1, 2011; Sayfa/Page 46-50 frequently reported as LSiL/aCH or LSiL where HSiL cannot be excluded (LSiL-H). recent studies have found the rate of a cervical intraepithelial lesion 2 (Cin2) or higher diagnosis in these biopsy materials to be higher than those that received a diagnosis of LSiL only (2)(3)(4)(5)(6)(7)(8)(9). This rate is seen to be similar to that of receiving a diagnosis of Cin2 or above on histopathology for patients with a diagnosis of aSC-H. We aimed to compare the LSiL/aSC-H diagnosis and LSiL-aSC-H, HSiL diagnosis in conventional Pap smears and to evaluate the clinical significance of these results especially for LSiL/aSC-H in this study.…”

Follow-up of women with atypical squamous cells cannot exclude high-grade squamous intraepithelial lesions (ASC-H)

“…18 This is consistent with the results obtained from the majority of the studies observed, which demonstrated CIN II+ prevalences of more than 40%, according to the biopsy results. 3,5,6,[17][18][19][20][21][22][23][24]29 Our results confirmed that at the time of the first ASC-H report, immediate intervention with colposcopy was necessary, followed by a biopsy. This validates the medical management of ASC-H that is required by the "management algorithm from the time of the first atypical Pap, " which is included in the Chilean Ministry of Health's Clinical Guidelines for Cervical Cancer.…”