Clinical Significance of Surveillance Culture in Liver Transplant Recipients

Kim, Y.J.; Kim, S.I.; Jun, Yoon Hee; Choi, Jung‐Hyun; Yoon, Seung Kew; You, Yong‐Ouk; Kim, D.-G.

doi:10.1016/j.transproceed.2013.11.030

Cited by 7 publications

(11 citation statements)

References 14 publications

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“…(20,21) In the present study, modifying the surgical prophylaxis did not prevent the occurrence of post-LT CRAB infection. However, because of the small number of patients, it was not possible to draw a conclusion about the efficacy of that measure.…”

Section: Discussioncontrasting

confidence: 59%

“…There is little knowledge regarding outcomes in SOT recipients colonized by MDR-GNB before transplant, and the impact of modifying the surgical prophylaxis has not been established. (20,21) In the present study, modifying the surgical prophylaxis did not prevent the occurrence of post-LT CRAB infection. However, because of the small number of patients, it was not possible to draw a conclusion about the efficacy of that measure.…”

Section: Discussioncontrasting

confidence: 59%

“…The impact that pre-LT colonization by MDR-GNB has on infectious outcomes after LT has not been well defined. Kim et al (20) reported that, in a small number of LT recipients, colonization by A. baumannii, identified in sputum on the day of LT, was associated with the risk of A. baumannii-associated pneumonia in the posttransplant period. In another study, involving 475 LT recipients, microbiologically proven pre-LT infection was found to be a risk factor for post-LT death from MDR-GNB infection.…”

Section: Discussionmentioning

confidence: 99%

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Carbapenem‐resistant A cinetobacter baumannii acquired before liver transplantation: Impact on recipient outcomes

et al. 2016

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Infection with carbapenem-resistant Acinetobacter baumannii (CRAB) after liver transplantation (LT) is associated with high mortality. This study aimed to identify risk factors for post-LT CRAB infection, as well as to evaluate the impact of pre-LT CRAB acquisition on the incidence of post-LT CRAB infection. This was a prospective cohort study of all patients undergoing LT at our facility between October 2009 and October 2011. Surveillance cultures (SCs) were collected immediately before LT and weekly thereafter, until discharge. We analyzed 196 patients who were submitted to 222 LTs. CRAB was identified in 105 (53.6%); 24 (22.9%) of these patients were found to have acquired CRAB before LT, and 85 (81.0%) tested positive on SCs. Post-LT CRAB infection occurred in 56 (28.6%), the most common site being the surgical wound. Multivariate analysis showed that the risk factors for developing CRAB infection were prolonged cold ischemia, post-LT dialysis, LT due to fulminant hepatitis, and pre-LT CRAB acquisition with pre-LT CRAB acquisition showing a considerable trend toward significance (P = 0.06). Among the recipients with CRAB infection, 60-day mortality was 46.4%, significantly higher than among those without (P < 0.001). Mortality risk factors were post-LT infection with multidrug-resistant bacteria, LT performed because of fulminant hepatitis, retransplantation, prolonged cold ischemia, longer LT surgical time, and pre-LT CRAB acquisition, the last showing a trend toward significance (P = 0.08). In conclusion, pre-LT CRAB acquisition appears to increase the risk of post-LT CRAB infection, which has a negative impact on recipient survival. Liver Transplantation 22 615-626 2016 AASLD.

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Section: Discussioncontrasting

confidence: 59%

Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

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Carbapenem‐resistant A cinetobacter baumannii acquired before liver transplantation: Impact on recipient outcomes

et al. 2016

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“…2 Kolonisasi dapat dideteksi dengan menggunakan kultur swab nasal/ kulit atau metode identifikasi cepat seperti PCR atau chromogenic agar. 4 Pemilihan jenis antibiotik untuk profilaksis sebelum operasi ditentukan berdasarkan data epidemiologi setempat, secara umum generasi ketiga cephalosporin (cefotaxime) dan ampicillin atau piperacillin-tazobactam dapat digunakan sebagai profilaksis yang diberikan selama 1-3 hari. Cefotaxime memberikan cakupan terhadap aktifitas kuman Staphylococcus dan ampicillin memiliki efek anti-enterococci, sementara aktifitas antimikroba piperacillin-tazobactam mencakup Enterobacteriaceae, Enterococci, dan Pseudomonas.…”

Section: B Profilaksis Sebelum Transplantasi Antibiotikunclassified

Protokol Evaluasi Infeksi Bakteri Pre- dan Pasca-Transplantasi Hati Anak

Karyanti¹,

Putri²,

Oswari³

2019

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Infeksi pre- dan pasca-transplantasi hati dipengaruhi oleh gangguan sistem imunonlogi resipien karena penggunaan obat-obat imunosupresi. Komplikasi infeksi tersebut merupakan penyebab penting kejadian infeksi terhadap morbiditas dan mortalitas pada anak anak yang menjalani transplantasi hati. Obat-obatan profilaksis sebelum dan setelah operasi yang direkomendasikan disesuaikan dengan pola mikroba yang berkaitan di setiap rumah sakit. Uji tapis infeksi bakteri penting untuk mencegah terjadinya infeksi pasca-transplantasi hati. Komplikasi terjadinya infeksi sekunder oleh bakteri disebabkan oleh karena penggunaan alat-alat invasif dalam jangka waktu yang lama seperti kateter vena sentral, kateter akses arterial, endotracheal tube, kateter ureter, dan sebagainya. Keberhasilan efektivitas pengobatan antimikroba ditentukan oleh pengelolaan pemasangan atau pelepasan semua alat invasif dan pengontrolan infeksi di rumah sakit.

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“…baumannii, identified in sputum on the day of LT, was associated with the risk of A. baumannii-associated pneumonia in the post-transplant period. (99) In another study, involving 475 LT recipients, microbiologically proven pre-LT infection was found to be a risk factor for post-LT death from MDR GNB infection. (18) In one study, surveillance samples were collected to culture for extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae before LT (19) .…”

Section: Kim Et Al Reported That In a Small Number Of Lt Recipientsmentioning

confidence: 96%

Aquisição de bactéria gram-negativa multidroga resistente antes do transplante de fígado: o impacto no desfecho

Freire¹

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Clinical Significance of Surveillance Culture in Liver Transplant Recipients

Cited by 7 publications

References 14 publications

Carbapenem‐resistant A cinetobacter baumannii acquired before liver transplantation: Impact on recipient outcomes

Carbapenem‐resistant A cinetobacter baumannii acquired before liver transplantation: Impact on recipient outcomes

Protokol Evaluasi Infeksi Bakteri Pre- dan Pasca-Transplantasi Hati Anak

Aquisição de bactéria gram-negativa multidroga resistente antes do transplante de fígado: o impacto no desfecho

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