Clinical significance of serum triglyceride elevation at early stage of acute biliary pancreatitis

Cheng, Long; Luo, Zhigang; Ke, Xiang; Ren, Jiandong; Huang, Zhu; Tang, Lijun; Tian, Fanghua

doi:10.1186/s12876-015-0254-x

Cited by 23 publications

(27 citation statements)

References 31 publications

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“…TC, L-DL, and high levels of diabetes B were not associated with gallstones. Previous studies on the relationship between cholesterol and LDL and gallstones were contradictory, and several cross-sectional studies were reported as reverse [22,23], positive [24][25][26], and ineffective [27,28], Several prospective studies of gallstones were not associated with TC and/or low-density lipoprotein [29,30]. The reasons for these inconsistencies are unclear but may be due to differences in research design, research population, lipid measurement methods, or mixed control deficiencies.…”

Section: Discussionmentioning

confidence: 99%

Serum lipid levels are the risk factors of gallbladder stones: a population-based study in China

et al. 2020

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Background: Gallstones are the cause of a majority of biliary tract discomfort. Although many community-based studies have addressed the risk factors for gallstone disease (GSD), little is known about GSD prevalence and risk factors in Chinese populations. , participants (N = 2,068,523) were recruited by Meinian Onehealth Healthcare Co., Ltd. They received a physical examination, and GSD was determined by ultrasound. Results: The prevalence of GSD was 8.1%. Risks of GSD were similar between males and females in all age groups. Risk factors for gallstones include body mass index, waist circumference, waist-to-hip ratio, and physical activity, as well as biological factors such as age, sex, and elevated blood lipid levels. Serum lipid levels of GSD were statistically different from controls in total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (H-DL), lowdensity lipoprotein cholesterol (LDL), and apolipoprotein B (APOB). Furthermore, TC > 5.00 mmol/L, TG > 1.39 mmol/L, HDL < 1.19 mmol/L, LDL > 3.04 mmol/L, and APOB > 0.97 mmol/L were risk factors for gallstones. Conclusions: Serum lipid levels are associated with GSD. TC, TG, LDL, and APOB are risk factors, while HDL is a protective factor.

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Section: Discussionmentioning

confidence: 99%

Serum lipid levels are the risk factors of gallbladder stones: a population-based study in China

et al. 2020

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“…[ 5 ] Elevated triglyceride levels have been shown to increase the severity and mortality in biliary pancreatitis. [ 6 ] In a study by Navarro,[ 7 ] HTGP patients had more severe disease and more complications than patients with biliary pancreatitis. Heavy alcohol intake is also a risk factor for the development of HTG and it has been suggested that alcohol use be stopped in patients with concurrent HTG.…”

Section: Introductionmentioning

confidence: 99%

Differences in severity and outcomes between hypertriglyceridemia and alcohol-induced pancreatitis

et al. 2016

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Background:Alcohol and hypertriglyceridemia (HTG) are among the most common causes of acute pancreatitis (AP) after gallstones. However, differences in severity at the time of presentation and outcomes have not been well-studied.Objective:The aim of this study is to assess the differences between severity at presentation and outcomes of AP of hypertriglyceridemic and alcoholic origins.Materials and Methods:A retrospective review of 177 patients who were discharged with diagnosis of AP was performed. Severity at presentation was identified by the presence of systemic inflammatory response syndrome, bedside index for severity in AP (BISAP) score, and Balthazar index. Outcomes were measured by the length of stay, intensive care unit care, surgical intervention, and mortality.Results:We found 147 patients with alcoholic pancreatitis and 30 patients with hypertriglyceridemic pancreatitis. A larger percentage of hypertriglyceridemic pancreatitis patients (23.33%) had a BISAP score of ≥2 compared to the alcoholic group (12.24%). Only 32.65% of the patients with alcoholic pancreatitis but 60% of the patients with hypertriglyceridemic pancreatitis had the presence of systemic inflammatory response syndrome (SIRS) at admission (P = 0.0067). There were 73.34% hypertriglyceridemic pancreatits patients and only 40.28% alcoholic pancreatitis patients with Balthazar index C or greater, suggesting a higher disease burden at admission for hypertriglyceridemic pancreatitis patients (P = 0.0047). There was a statistically significant difference in the relative number of hypertriglyceridemic and alcoholic pancreatitis patients receiving intensive care (P = 0.00030) and in receiving surgical interventions related to pancreatitis (P = 0.016).Conclusion:Our study found that patients with hypertriglyceridemic pancreatitis have a greater severity of disease and they experience less favorable outcomes than patients with alcoholic pancreatitis.

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“…Hypertriglyceridemia (HTG) accounts for 1 to 4 percent of cases of acute pancreatitis [ 8 , 9 ]. On the other hand, HTG is commonly present at the early stage of non-HTG-induced AP and its clinical significance remains unclear [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Serum Triglyceride Level: A Predictor of Complications and Outcomes in Acute Pancreatitis?

Tariq

Gaduputi

Peralta

et al. 2016

Canadian Journal of Gastroenterology and Hepatology

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Aim. To study serum triglyceride level as a predictor of complications and outcomes in acute pancreatitis. Methods. In this retrospective observational study, 582 patients admitted with acute pancreatitis, who had serum triglyceride levels measured within the first 24 hours, were divided into two groups. The study group consisted of patients with a triglyceride level ≥2.26 mmol/L (group 2) and the control group consisted of triglyceride level of <2.26 mmol/L (group 1). We collected data for baseline demographics, laboratory values, incidence of complications (local and systemic), admission to the intensive care unit (ICU), ICU length of stay, length of total hospital stay, and death in the two groups. Results. A triglyceride level of ≥2.26 mmol/L was found to be an independent predictor of developing altered mental status (p: 0.004), pancreatic necrosis (p: 0.001), acute respiratory distress syndrome (p: 0001), systemic Inflammatory response syndrome (p: 0.001), acute kidney injury (p: 0.001), hospital length of stay (LOS) (p: 0.002), admission to intensive care unit (ICU) (p: 0.002), and ICU LOS (p: 0.003). Conclusion. A triglyceride level of ≥2.26 mmol/L on admission in acute pancreatitis is an independent predictor of developing local and systemic complications, hospital LOS, admission to ICU, and ICU LOS.

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Clinical significance of serum triglyceride elevation at early stage of acute biliary pancreatitis

Cited by 23 publications

References 31 publications

Serum lipid levels are the risk factors of gallbladder stones: a population-based study in China

Serum lipid levels are the risk factors of gallbladder stones: a population-based study in China

Differences in severity and outcomes between hypertriglyceridemia and alcohol-induced pancreatitis

Serum Triglyceride Level: A Predictor of Complications and Outcomes in Acute Pancreatitis?

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