Clinical significance of serum transaminase values in patients with renal failure.

Yazaki, Kunihiko; Oguchi, Hisao; Tokunaga, Shinichi; Kobayashi, Mamoru; Yamazaki, Tomoo; Hayashi, Keisuke; Tokoo, Masuo; Hora, Kazuhiko; Furuta, Seiichi

doi:10.4009/jsdt.27.1451

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“…The pre cise mechanism of decreased aminotransferase levels in hemodialysis patients has not been clarified yet. but lack of vitamin B6 and/or cofactors has been incriminated [10][11][12], More recently, it has been reported that an unknown uremic substance that is not exchangeable by hemodialysis plays an important role to inhibit the activi ty of serum aminotransferases [13], These findings, how ever, raise the question whether there is actually liver injury in these patients.…”

Section: Discussionmentioning

confidence: 94%

Characteristics of Anti-HCV Antibody-Positive Patients with Hepatocellular Carcinoma on Chronic Hemodialysis: Recommendation of Periodic Ultrasonography for Early Detection

Sakai

Izumi

Tazawa

et al. 1996

Nephron

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We analyzed 10 patients (male:female 9:1, mean age 64.2 years) who developed hepatocelluar carcinoma during the observation period of 2 years among 2,164 chronic hemodialysis patients in 23 dialysis centers. Among them, 409 patients were positive for serum anti-HCV antibodies (19%). They were all positive for serum anti-HCV antibodies but negative for HBs antigen. None of the anti-HCV antibody-negative patients developed hepatocellular carcinoma during this period. Although liver function tests of the patients were almost normal, pathological examination of the liver revealed chronic active hepatitis or cirrhosis. Periodic ultrasonographic examination is necessary for early detection of hepatocellular carcinoma in chronic hemodialysis patients with positive anti-HCV antibodies even if liver function tests are within normal ranges.

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Section: Discussionmentioning

confidence: 94%