Clinical significance of serum pancreatic enzymes in the quiescent phase of chronic pancreatitis

Lesi, C.; d’Eril, G.V. Melzi; Pavesi, Franco; A, Scandellari; Faccenda, Franca; Casertano, Marianna; Savoia, Marinella; Zoni, L.; M, Peppi

doi:10.1016/s0009-9120(85)80047-3

Cited by 9 publications

(2 citation statements)

References 12 publications

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“…Instead, we used p-type isoamylase as an indicator of the exocrine pancreatic function because a previously published studies demonstrated that a lowered p-type isoamylase level in the serum could provide either supportive or diagnostic evidence for pancreatic insuffi ciency. 13,14 The total amylase level in the serum was of no diagnostic value in this study because salivary isoamylase showed a compensatory elevation (data not shown).…”

Section: Discussionmentioning

confidence: 65%

Long-Term Assessments After Pancreaticoduodenectomy with Pancreatic Duct Invagination Anastomosis

et al. 2007

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Section: Discussionmentioning

confidence: 65%

Long-Term Assessments After Pancreaticoduodenectomy with Pancreatic Duct Invagination Anastomosis

et al. 2007

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“…Clinically, serum amylase and serum lipase are widely used as markers of pancreatitis. However, these markers are not sensitive, show low specificity and are primarily used as additional tools (27). Abnormal levels of serum amylase and serum lipase are caused by Metabolic characteristics of acute necrotizing pancreatitis and chronic pancreatitis a block in the excretion of pancreatic juice, which causes changes in pancreatic function.…”

Section: Introductionmentioning

confidence: 99%

Metabolic characteristics of acute necrotizing pancreatitis and chronic pancreatitis

Tian

Wang

et al. 2012

Mol Med Report

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Abstract. The etiology and pathogenesis of pancreatitis remains unclear. In the presence of pancreatic inflammation, metabolite abnormalities appear before transformation of tissue structure and changes in functions occur. Detection of abnormalities in metabolite levels facilitates a greater understanding of the pathophysiological events and aids in the early diagnosis of the disease. In this study, metabolic profiles from the pancreas of Wistar rats were examined using high-resolution proton magic angle spinning nuclear magnetic resonance (MAS NMR) spectroscopy to investigate the metabolite indicator(s) of acute necrotizing pancreatitis (ANP) and chronic pancreatitis (CP). The animals were divided into three groups: those with histologically confirmed ANP (n=7), those with CP (n=6) and a control group (n=9). The processed NMR spectra were analyzed using principal component analysis (PCA) to extract characteristic metabolites of ANP and CP. Levels of leucine, isoleucine and valine were increased in the ANP group, whereas an opposite trend was observed in the CP group. Increases in phosphocholine, glycerophosphocholine and choline levels, and decreases in fatty acids, lactate, betaine and glycine levels were observed in both the ANP and CP groups. Additionally, the lipid content in the CP group was higher than that observed in the ANP group. An increase in taurine levels was observed only in the CP group. In conclusion, pancreatitis causes a disruption of the metabolism in the pancreas at a molecular level, with increased taurine levels being a potential metabolite indicator for those with CP.

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Role of Serum Enzymes in Chronic Pancreatitis

Favero

Fabris

Basso

et al. 1990

Chronic Pancreatitis

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Clinical significance of serum pancreatic enzymes in the quiescent phase of chronic pancreatitis

Cited by 9 publications

References 12 publications

Long-Term Assessments After Pancreaticoduodenectomy with Pancreatic Duct Invagination Anastomosis

Long-Term Assessments After Pancreaticoduodenectomy with Pancreatic Duct Invagination Anastomosis

Metabolic characteristics of acute necrotizing pancreatitis and chronic pancreatitis

Role of Serum Enzymes in Chronic Pancreatitis

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