Clinical significance of serum interleukin-23 and A/G gene (rs17375018) polymorphism in Behçets disease: Relation to neuro-Behçet, uveitis and disease activity

Gheita, Tamer A.; Gamal, Sherif M.; Shaker, Ihab; Fishawy, Hussein S. El; Sisi, Rehab El; Shaker, Olfat; Kenawy, Sanaa A.

doi:10.1016/j.jbspin.2014.10.008

Cited by 30 publications

(21 citation statements)

References 7 publications

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“…involvement, known as "Neuro-BS" (NBS) [1][2][3]. BS inflammatory features were studied in several genetics studies with focus on single nucleotide polymorphisms (SNPs) of genes involved in inflammation and immune response [4,5].…”

Section: Resultsmentioning

confidence: 99%

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AB0013 GENOMIC PROFILING OF INFLAMMATION-RELATED GENES IN NEURO-BEHçET SYNDROME: A PRELIMINARY ITALIAN STUDY

Padula

Leccese²,

Lascaro³

et al. 2019

Abstracts Accepted for Publication

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Section: Resultsmentioning

confidence: 99%

“…BS inflammatory features were studied in several genetics studies with focus on single nucleotide polymorphisms (SNPs) of genes involved in inflammation and immune response [4,5]. A very few papers assessed the mutational state of NBS patients and this characterization was limited to a small number of SNPs [3].…”

Section: Resultsmentioning

confidence: 99%

AB0013 GENOMIC PROFILING OF INFLAMMATION-RELATED GENES IN NEURO-BEHçET SYNDROME: A PRELIMINARY ITALIAN STUDY

Padula

Leccese²,

Lascaro³

et al. 2019

Abstracts Accepted for Publication

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“…IL23 influences Th17 cell responses but shares a common p40 subunit with IL12 [119], and like IL12 has also been shown to be elevated in BD patients with active disease [101,105,120,121]. Ustekinumab, a therapeutic agent, targeting both IL12 and IL23 cytokines has been shown to be therapeutic in BD [122], and subsequently a phase 2 open-label study to evaluate the proofof-concept of ustekinumab in BD (STELABEC) has been recently registered in France.…”

Section: Helper and Regulatory T Lymphocytes Involvement In Bdmentioning

confidence: 99%

Etiology, Immunopathogenesis and Biomarkers in Behçet’s disease

Adeeb¹,

Khan²,

Stack³

et al. 2017

Behcet's Disease

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Behçet's disease (BD) is a type of vasculitis with many distinctive clinical manifestations and multifactorial immunopathogenesis. The cause of BD remains unknown, but it has been postulated that in a genetically predisposed or susceptible population, exogenous agents trigger the dysregulation of both autoinflammatory and autoimmune responses resulting in multisystem vasculitis. There are robust ongoing efforts across the globe to elucidate and identify signature markers to improve and assist in rapid diagnosis of the disease and to tailor the best therapy accordingly. While association of human leukocyte antigen (HLA)-B * 51 (B * 51:01 subtype) allele is well recognized as the strongest genetic susceptibility gene so far among genetically predisposed BD patients, further investigations using the latest technology have led to the identification of several novel single nucleotide polymorphisms (SNPs) and other associated genes involved in the pathogenesis. There are several "established" cytokines known to be involved in the pathogenesis of BD, which have been further implicated in the genome-wide association studies (GWAS)-based cytokine/receptor gene loci studies, as well as numerous "novel" cytokines, which are currently being studied and identified. This chapter offers insights into current knowledge and thoughts regarding the future of biomarkers in BD.

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“…Several markers and mechanisms have been involved in the pathogenesis of BD and development of vascuitis including oxidative stress [2], apoptosis [3,4], cytokine and adipocytokine overproduction [5][6][7], vascular endothelial growth factors [8,9] and gene polymorphism [10]. Vasculitis and endothelial dysfunction are believed to be the pathogenic mechanism of a part but not the whole of the clinical spectrum of the disease [11].…”

Section: Introductionmentioning

confidence: 99%

Assessment of left ventricular function and aortic elastic properties in patients with Behçet’s disease using conventional and tissue Doppler echocardiography

Hassan

Ebaid

2016

The Egyptian Rheumatologist

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Background: Behc¸et disease (BD) is a multisystemic, chronic inflammatory disorder of unknown etiology with diffuse clinical manifestations including the cardiovascular system.Aim of the work: To assess left ventricular (LV) function and thoracic aorta elastic properties in BD patients using Doppler echocardiography and to correlate echocardiographic findings with disease activity.Patients and methods: The LV functions and thoracic aorta elastic properties were assessed in 30 BD patients and 30 controls using conventional and Tissue Doppler Imaging (TDI) echocardiography. Disease activity was evaluated using Behc¸et's disease current activity form (BDCAF). Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), cholesterol and triglyceride levels were measured.Results: In BD patients, ESR and CRP were significantly elevated while cholesterol and triglycerides were comparable to the levels in the control. In conventional echocardiography, BD patients had significantly higher aortic diastolic diameter (p < 0.05), aortic stiffness index (p < 0.001), isovolumic relaxation time (p < 0.001), flow propagation velocity (FPV) and peak E-wave velocity/FPV (E/FPV) (p < 0.001) than the control group while aortic strain was significantly lower

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Clinical significance of serum interleukin-23 and A/G gene (rs17375018) polymorphism in Behçets disease: Relation to neuro-Behçet, uveitis and disease activity

Cited by 30 publications

References 7 publications

AB0013 GENOMIC PROFILING OF INFLAMMATION-RELATED GENES IN NEURO-BEHçET SYNDROME: A PRELIMINARY ITALIAN STUDY

AB0013 GENOMIC PROFILING OF INFLAMMATION-RELATED GENES IN NEURO-BEHçET SYNDROME: A PRELIMINARY ITALIAN STUDY

Etiology, Immunopathogenesis and Biomarkers in Behçet’s disease

Assessment of left ventricular function and aortic elastic properties in patients with Behçet’s disease using conventional and tissue Doppler echocardiography

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