Clinical significance of serum diamine oxidase activity in inflammatory bowel disease

Methods to determine intestinal permeability and bacterial translocation during liver disease

“…Diamine oxidase (DAO) activity in serum correlates inversely with intestinal permeability of the small intestine (Luk et al, 1980; Honzawa et al, 2011). DAO is the main enzyme to catalyze the oxidation of diamines such as histamine, putrescine, and cadaverine (Shakir et al, 1977).…”

“…In the intestine, DAO is specifically located in tips of enterocyte villi, and its activity reflects the integrity and maturity of the small intestinal mucosa (Luk et al, 1980). Serum DAO activity is significantly decreased in patients with Crohn’s disease and ulcerative colitis regardless of the level of disease activity (Honzawa et al, 2011). Considering that serum DAO activity could be easily measured with Enzyme Immunoassay using a commercial kit, it might thus become a convenient method for evaluating small intestinal permeability in patients with intestinal diseases in the future.…”

227 Effect of different cooking methods on histamine levels in selected foods

“…Impaired histamine degradation based on reduced DAO activity, and the resulting excess of histamine, may cause numerous symptoms mimicking an allergic reaction 1 . There are some concrete clinical examples of reduced DAO activity including the subgroup of patients those with atopic dermatitis 7 , that are pregnant 8 , and other chronic disease (e.g., liver cirrhosis 9 , anorexia nervosa 10 , inflammatory bowel disease: ulcerative colitis and Crohn's disease 11 ), and those that use anticancer drugs 12 . Even the abundance of histamine is not the only causative factor for food allergy, there are some evidences which address Table 1.…”

Serum diamine oxidase activity as a predictor of gastrointestinal toxicity and malnutrition due to anticancer drugs

“…reported that DAO activity in the blood significantly correlates with DAO activity in the tissues of the small intestine in animals . Several studies have been reported in which DAO activity was measured and small intestinal lesions were assessed in patients with inflammatory bowel disease, acute mesenteric ischemia, and other diseases . However, there have been only a few reports on the relationship between DAO activity and anticancer‐drug‐induced mucosal damage .…”