Clinical significance of REM sleep behavior disorder in Parkinson’s disease

Nomura, Takashi; Inoue, Yuichi; Kagimura, Tatsuo; Nakashima, Kenichiro

doi:10.1016/j.sleep.2012.10.011

Cited by 102 publications

(71 citation statements)

References 27 publications

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“…Another 1,187 studies were excluded because they were reviews (n = 655), case reports (n = 166), animal studies (n = 306) or editorials (n = 50). Ultimately, 31 articles1278202122232425262728293031323334353637383940414243444546 were included in our analysis (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Clinical variations in Parkinson’s disease patients with or without REM sleep behaviour disorder: a meta-analysis

Zhu

Xie

et al. 2017

Sci Rep

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This study aimed to evaluate the clinical variations in patients with Parkinson’s disease (PD) with (PDRBD) or without REM sleep behaviour disorder (RBD) (Non-RBD), and PDRBD patients were classified into Confirmed-RBD (definite diagnosis with polysomnography, PSG) and Probable-RBD (without PSG re-confirmation). The clinical difference between the groups of patients was measured as an odds ratio (OR) or standardized mean difference (SMD, Cohen d). A total of 31 articles with data from 5,785 participants were obtained for our analysis. Overall, the occurrence of Confirmed-RBD was more frequent in male patients (OR = 1.25; p = 0.038), elderly patients (SMD = 0.25; p = 0.000), and patients with longer disease duration (SMD = 0.30; p = 0.000), increased Hoehn-Yahr scale (SMD = 0.30; p = 0.000), and higher UPDRS-III score (SMD = 0.38; p = 0.002). On the other hand, the frequency of Probable-RBD was increased with disease duration (SMD = 0.29; p = 0.000), Hoehn-Yahr scale (SMD = 0.30; p = 0.000), and UPDRS-III score (SMD = 0.26; p = 0.001). Our study indicate that PDRBD patients may have different clinical features compared to patients with Non-RBD.

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Section: Resultsmentioning

confidence: 99%

Clinical variations in Parkinson’s disease patients with or without REM sleep behaviour disorder: a meta-analysis

Zhu

Xie

et al. 2017

Sci Rep

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“…While PSG inevitably remains the gold standard, studies have supported the use of RBDSQ in screening for pRBD40 and its role in clinical studies. Importantly, it must also be noted that while the RBDSQ does not require the input from a bed partner, thus making it ideal for screening large populations where this information may not be available, this may lead to the underdiagnosis of pRBD.…”

Section: Discussionmentioning

confidence: 99%

REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson's disease

Rolinski

Szewczyk-Królikowski

Tomlinson

et al. 2013

Journal of Neurology, Neurosurgery & Psychiatry

156

109

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BackgroundConcomitant REM sleep behaviour disorder (RBD) is commonly observed in patients with Parkinson's disease (PD). Although the brainstem structures responsible for the symptoms of RBD correspond to the premotor stages of PD, the association of RBD with motor and non-motor features in early PD remains unclear.MethodsThe study evaluated 475 patients with PD within 3.5 years of diagnosis for the presence of probable RBD (pRBD) using the REM Sleep Behaviour Disorder Screening Questionnaire (RBDSQ). A neurologist and a trained research nurse carried out evaluation of each participant blinded to the results of the RBDSQ. Standardised rating scales for motor and non-motor features of PD, as well as health-related quality of life measures, were assessed. Multiple linear and logistic regression analyses were used to determine the relationship between pRBD and a variety of outcomes, controlling for confounding factors.ResultsThe overall frequency of pRBD was 47.2% (95% CI 42.7% to 51.9%). None of the patients had a previous diagnosis of RBD. Patients with PD and concomitant pRBD did not differ on motor phenotype and scored comparably on the objective motor scales, but reported problems with motor aspects of daily living more frequently. Adjusted for age, sex, disease duration and smoking history, pRBD was associated with greater sleepiness (p=0.001), depression (p=0.001) and cognitive impairment (p=0.006).ConclusionspRBD is common and under-recognised in early PD. It is associated with increased severity and frequency of non-motor features, poorer subjective motor performance and a greater impact on health-related quality of life.

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“…When it occurs, it is associated with visuo-perceptual dysfunction, including errors in object recognition (Marques et al , 2010) and complex figure copying (Vendette et al , 2007). The presence of RBD in Parkinson’s disease is also predictive of progressive cognitive dysfunction (Sinforiani et al , 2008; Postuma et al , 2012; Nomura et al , 2013). …”

Section: Clinical Relevancementioning

confidence: 99%