Clinical significance of primary lesion FDG uptake for choice between oesophagectomy and endoscopic submucosal dissection for resectable oesophageal squamous cell carcinomas

Nakajo, Masatoyo; Nakajo, Masayuki; Tani, Akio; Kajiya, Yoriko; Shimaoka, Shunji; Matsuda, A; Nioh, Tatsuyuki; Nihara, Tohru; Suenaga, Toyokuni; Tanaka, Sadao; Shirahama, Hiroshi; Higashi, Michiyo; Koriyama, Chihaya

doi:10.1007/s00330-011-2196-1

Cited by 7 publications

(7 citation statements)

References 56 publications

(93 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some previous studies showed low sensitivity of FDG-PET for superficial ECs. The results of our study are consistent with these, and our study is highly important because it confirms the low sensitivity of FDG-PET for ECs in the screening setting[11,13,14,18]. Because of the very low sensitivity, it is believed that FDG-PET is difficult to use as a screening modality for ECs.…”

Section: Discussionsupporting

confidence: 89%

“…Although the usefulness of FDG-PET for the assessment of EC extension and metastasis, detection of EC recurrence after treatment, and evaluation of the response to therapy for EC has been well examined[11-17], only limited data are available on the performance of FDG-PET for EC screening. With respect to the diagnostic ability of FDG-PET for primary EC lesions, EC that invades the submucosal layer or deeper can reportedly be detected, but more superficial ECs are difficult to detect[11,13,14,18]. Based on this finding, it can be hypothesized that FDG-PET is not suitable for EC screening.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Performance of 18-fluoro-2-deoxyglucose positron emission tomography for esophageal cancer screening

Sekiguchi

Terauchi

Kakugawa

et al. 2017

WJG

View full text Add to dashboard Cite

AIMTo evaluate the performance of 18-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) for esophageal cancer (EC) screening.METHODSWe retrospectively analyzed the data of consecutive asymptomatic individuals who underwent FDG-PET and esophagogastroduodenoscopy (EGD) simultaneously for cancer screening at our institution from February 2004 to March 2013. In total, 14790 FDG-PET and EGD procedures performed for 8468 individuals were included in this study, and the performance of FDG-PET for EC screening was assessed by comparing the results of FDG-PET and EGD, considering the latter as the reference.RESULTSThirty-two EC lesions were detected in 28 individuals (31 squamous cell carcinomas and 1 adenocarcinoma). The median tumor size was 12.5 mm, and the depths of the lesions were as follows: Tis (n = 12), T1a (n = 15), and T1b (n = 5). Among the 14790 FDG-PET procedures, 51 examinations (0.3%) showed positive findings in the esophagus; only 1 was a true-positive finding. The screen sensitivity, specificity, positive predictive value, and negative predictive value of FDG-PET for ECs were 3.6% (95%CI: 0.1-18.3), 99.7% (95%CI: 99.6-99.7), 2.0% (95%CI: 0.0-10.4), and 99.8% (95%CI: 99.7-99.9), respectively. Of the 50 FDG-PET false-positive cases, 31 were observed in the lower esophagus, and gastroesophageal reflux disease was observed in 17 of these 31 cases.CONCLUSIONThis study is the first to clarify the FDG-PET performance for EC screening. Based on the low screen sensitivity, FDG-PET is considered to be difficult to use as a screening modality for ECs.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Performance of 18-fluoro-2-deoxyglucose positron emission tomography for esophageal cancer screening

Sekiguchi

Terauchi

Kakugawa

et al. 2017

WJG

View full text Add to dashboard Cite

show abstract

“…Westeterp et al [21] have revealed that tumor size and GLUT-1 expression had an influence on SUV max in ESCC. In contrast, Nakajo et al [22] have suggested that 18 F-FDG uptake in ESCC is associated with p-tumor size, GLUT-1 expression, and tumor depth. However, the p-tumor size is estimated on the basis of the largest diameter and does not always reflect accurate tumor cell density.…”

Section: Discussionmentioning

confidence: 88%

The difference in relationship between 18F-FDG uptake and clinicopathological factors on thyroid, esophageal, and lung cancers

Kaida

Kawahara

Hayakawa

et al. 2014

Nuclear Medicine Communications

View full text Add to dashboard Cite

show abstract

“…The rate of glucose transport via GLUT-1 may be altered under conditions in which the metabolic rate must be adjusted, including during cell division (mitosis and meiosis), differentiation, transformation and nutrient starvation (4). In previous studies (5)(6)(7)(8)(9)(10)(11), Glut-1 expression has been correlated with lymph node metastasis, poor survival rate and clinical stage of head and neck carcinoma (HNC).…”

Section: Introductionmentioning

confidence: 99%

Expression and significance of hypoxia-inducible factor-1α and glucose transporter-1 in laryngeal carcinoma

Chen

Jianying

et al. 2012

Oncology Letters

View full text Add to dashboard Cite

Abstract. Malignant cells show increased glucose uptake in vitro and in vivo. This process is considered to be mediated by glucose transporters (GLUTs). Hypoxia-inducible factor-1α (HIF-1α) may upregulate GLUT-1 expression. Little is known about the correlation between HIF-1α and GLUT-1 expression in laryngeal carcinoma. The current study investigated this correlation immunohistochemically, according to various clinical and pathological features, in 49 paraffin-embedded archival tissue blocks from patients with laryngeal squamous cell carcinoma. HIF-1α and GLUT-1 expression was detected in 63.3 (31/49) and 55.1% (27/49) of the tumour samples, respectively. HIF-1α expression was significantly correlated with lymph node classification (P= 0.018), recurrence (P= 0.02) and metastasis (P= 0.031). GLUT-1A expression was significantly associated with recurrence (P=0.02) and metastasis (P=0.01). Univariate analyses revealed that HIF-1α (χ 2 =8.2; P=0.004) and GLUT-1 expression (χ 2 =9.0; P=0.003) were significantly associated with a poorer survival rate. In a multivariate analysis, GLUT-1 expression (P=0.006) was a significant predictor of poor survival rate, as well as the primary tumour site, lymph node invasion and distant metastasis. Based on Spearman's analysis, GLUT-1 expression and phosphatidylinositol 3-kinase (PI3K) expression were significantly correlated (r=0.504; P=0.000). This is the first study to demonstrate a significant correlation between GLUT-1 and HIF-1α expression in laryngeal carcinoma and to show increased GLUT-1 expression as an independent survival rate predictor. These results suggest that GLUT-1 is a potential new therapeutic target for laryngeal carcinoma.

show abstract

Clinical significance of primary lesion FDG uptake for choice between oesophagectomy and endoscopic submucosal dissection for resectable oesophageal squamous cell carcinomas

Abstract: Primary lesion FDG visibility can be one of the indicators for choosing between oesophagectomy and ESD for resectable oesophageal SCCs.

Cited by 7 publications

References 56 publications

Performance of 18-fluoro-2-deoxyglucose positron emission tomography for esophageal cancer screening

Performance of 18-fluoro-2-deoxyglucose positron emission tomography for esophageal cancer screening

The difference in relationship between 18F-FDG uptake and clinicopathological factors on thyroid, esophageal, and lung cancers

Expression and significance of hypoxia-inducible factor-1α and glucose transporter-1 in laryngeal carcinoma

Contact Info

Product

Resources

About