Clinical significance of platelet‐to‐lymphocyte ratio in women with preeclampsia

Kim, Mina; Han, Gwan Hee; Kwon, Ja Young; Kim, Young-Han

doi:10.1111/aji.12973

Cited by 37 publications

(45 citation statements)

References 36 publications

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“…PLR has been shown to increase significantly in many inflammatory diseases (11,(13)(14)(15). Consistent with the literature, in our study, PLR was found to be significantly higher in patients with PID, whereas sensitivity (68%) and specificity (60%) of PLR were lower than NLR and WBC, and higher than MPV and PDW.…”

Section: Discussionsupporting

confidence: 91%

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Diagnostic Value of Hematological Parameters in Pelvic Inflammatory Disease

Aliyeva¹,

Kaya²,

Soyman³

et al. 2019

Istanbul Med J

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Section: Discussionsupporting

confidence: 91%

“…MPV, which is a marker of function and activation of platelets, is altered by platelet activation (12,13). MPV has been shown to decrease in inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease in recent studies (16,17).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Hematological Parameters in Pelvic Inflammatory Disease

Aliyeva¹,

Kaya²,

Soyman³

et al. 2019

Istanbul Med J

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“…Their deuterogenic parameters, such as NLR, LMR and PLR, were considered as the inflammation-related indicators with respect to predict many diseases, including pregnancy complications [22,23]. Several studies, sample size ranging from 107-814, suggested that maternal NLR/PLR was positive associated with severe pre-eclampsia/gestational diabetes mellitus/acute appendicitis during pregnancy [24,25,26]. However, some considered that NLR/PLR has no significant association with gestational diabetes mellitus and HELLP syndrome [27,28].…”

Section: Discussionmentioning

confidence: 99%

The benefits of higher LMR for early threatened abortion: A retrospective cohort study

Feng

Chen

et al. 2020

PLoS ONE

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To investigate the relation of inflammation-related parameters and pregnancy outcome in women with the early threatened abortion. Method of study 630 women with early threatened abortion were divided into two groups based on the pregnancy outcome. All of them had the blood routine examination before treating. The differences between two groups were analyzed by the Chi-squared test, Student T test, Mann-Whitney U test, Binary Logistic Regression, Marginal Structural Model and Threshold effect analysis. Results We found that there is no significant difference in the pregnancy outcome for NLR (OR:0.92, CI95%:0.72, 1.17) and PLR (OR:1.00, CI%:0.99, 1.01). However, a difference had a statistical significance in the pregnancy outcome when LMR less than 2.19 (OR:0.39, CI95%:0.19,0.82). Conclusions This study suggested that higher LMR was related to the lower risk of miscarriage in the women with early threatened abortion in a way.

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“…Other hematological and radiological variables studied along with PLT indices in preeclampsia have validated the use of MPV to prognosticate the disease progression. [192021] A study done by Kim et al . showed that PLT-lymphocyte ratio predicted a shorter time interval between admission and delivery of the preeclampsia cases.…”

Section: Discussionmentioning

confidence: 99%

Significance of platelet indices as severity marker in nonthrombocytopenic preeclampsia cases

Reddy

Prasad

2019

J Lab Physicians

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CONTEXT: Preeclampsia is often asymptomatic, and hence, its detection depends on signs or investigations. The platelet (PLT) parameters, in cases of preeclampsia with normal PLT count, are seldom analyzed. Hence, this study was undertaken to study the PLT parameters in nonthrombocytopenic preeclampsia cases. AIM: The aim was to evaluate the use of PLT indices as severity markers in nonthrombocytopenic preeclampsia cases. SUBJECTS AND METHODS: This prospective study was done on 120 cases of severe preeclampsia, 115 cases of preeclampsia without severe features, and 203 normal pregnant women admitted in the obstetrics wards during the study period of 1 year. The PLT indices obtained by analyzing anticoagulated blood were recorded. STATISTICAL ANALYSIS USED: Analysis of variance test was used to see the significance of association. Receiver operating characteristic (ROC) curve and binary regression analysis was used to estimate the cutoff value and examine the predictive value of the PLT parameters in the disease progression of preeclampsia. RESULTS: Even in the absence of thrombocytopenia, mean platelet volume (MPV) and PLT distribution width were significantly higher in severe preeclampsia group (P < 0.001) and were also positively correlating with mean arterial pressure (r = 0.38 and 0.20, respectively). ROC curve analysis showed that MPV had the highest area under the curve of 0.78 (95% confidence interval [0.719‒0.842]). Cutoff value of >10.95 fl for MPV was found to have significant predictive value for disease progression in preeclampsia. CONCLUSIONS: Even in the absence of thrombocytopenia, PLT indices, especially MPV, have a good diagnostic significance in detecting severe preeclampsia. Further studies are required to evaluate their role as biomarkers in preeclampsia.

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Clinical significance of platelet‐to‐lymphocyte ratio in women with preeclampsia

Abstract: The PLR is an easily accessible and cost-effective parameter, which may be used as a more useful marker for prediction of PE compared to platelet indices. Our study showed that PLR can serve as a useful diagnostic marker of PE.

Cited by 37 publications

References 36 publications

Diagnostic Value of Hematological Parameters in Pelvic Inflammatory Disease

Diagnostic Value of Hematological Parameters in Pelvic Inflammatory Disease

The benefits of higher LMR for early threatened abortion: A retrospective cohort study

Significance of platelet indices as severity marker in nonthrombocytopenic preeclampsia cases

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