Clinical significance of plasma MMP‐2 and MMP‐9 levels as biomarkers for tumor expression in breast cancer patients in Egypt

Alrehaili, Amani A.; Gharib, Amal F.; Karam, Rehab A.; Alhakami, Reem Ali; Sawy, Wael Hassan El; Elrahman, Tamer M. Abd

doi:10.1007/s11033-019-05216-5

Cited by 18 publications

(11 citation statements)

References 24 publications

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“…Expression of MMP-2 was not found to be differentially regulated between the tumor and adjacent normal tissue in both the cohort. These observations are in alliance with a recent finding that showed no significant difference in MMP-2 levels between breast cancer and normal tissues 40 . On the contrary, the levels of MMP-2 were significantly upregulated in colorectal cancer tissues than in normal tissues 41 .…”

Section: Discussionsupporting

confidence: 90%

Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance

Bhadwal

Randhawa

Vaiphei

et al. 2022

Sci Rep

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Despite numerous reports on the altered sphingolipids metabolism in human cancers, their clinical significance in breast cancer remains obscure. Previously, we identified the high levels of sphingolipids, ceramide phosphates and sphingosine phosphates, and the genes involved in their synthesis, CERK and SPHK1, in breast cancer patients. The present study aimed to determine the correlations of CERK and SPHK1 with clinical outcomes as well as metastasis and drug resistance markers. Both local and TCGA cohorts were analysed. High-confidence regulatory interaction network was constructed to find association of target genes with metastasis and drug resistance. Furthermore, correlations of CERK and SPHK1 with selected metastasis and drug resistance markers were validated in both cohorts. Overexpression of CERK and SPHK1 was associated with nodal metastasis, late tumor stage and high proliferation potency. In addition, increased CERK expression was also indicative of poor patient survival. Computational network analysis revealed the association of CERK and SPHK1 with known metastasis markers MMP-2 and MMP-9 and drug resistance markers ABCC1 and ABCG2. Correlation analysis confirmed the associations of target genes with these markers in both local as well as TCGA cohort. The above findings suggest clinical utility of CERK and SPHK1 as potential biomarkers in breast cancer patients and thus could provide novel leads in the development of therapeutics.

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Section: Discussionsupporting

confidence: 90%

Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance

Bhadwal

Randhawa

Vaiphei

et al. 2022

Sci Rep

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“… 28 29 MMP-2 and MMP-9 are crucial regulators in TPC cell migration. 30 31 Our results showed that SOX12 silencing suppresses the expression of PCNA, Cyclin D1, Snail, MMP-2, and MMP-9 and promotes E-cadherin expression. Accordingly, we deemed that SOX12 promotes the proliferation, migration, and invasion of thyroid cancer cells by regulating the expression of PCNA, Cyclin D1, E-cadherin, Snail, MMP-2, and MMP-9.…”

Section: Discussionmentioning

confidence: 69%

SOX12 Promotes Thyroid Cancer Cell Proliferation and Invasion by Regulating the Expression of POU2F1 and POU3F1

Bao

Yang

et al. 2022

Yonsei Med J

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Purpose SOX12 is overexpressed in many cancers, and we aimed to explore the biological function and mechanism of SOX12 in thyroid cancer. Materials and Methods We first analyzed the expression of SOX12 in thyroid cancer using data in The Cancer Genome Atlas. Immunohistochemistry and qRT-PCR were performed to identify SOX12 expression in thyroid cancer tissue and cells. Thyroid cancer cells were transfected with small interfering RNA targeting SOX12, and cellular functional experiments, including CCK8, wound healing, and Transwell assays, were performed. Protein expression was examined by Western blot analysis. A xenograft model was developed to evaluate the effect of SOX12 on tumor growth in vivo. Results SOX12 expression was increased in thyroid cancer tissue and cells. SOX12 promoted cell proliferation, migration, and invasion and accelerated tumor growth in vivo. The expression of PCNA, Cyclin D1, E-cadherin, Snail, MMP-2, and MMP-9 was affected by SOX12 knockdown. Bioinformatic analysis showed that SOX12 could interact with the POU family. SOX12 knockdown inhibited the expression of POU2F1, POU2F2, POU3F1 and POU3F2, and SOX12 expression showed a positive correlation with POU2F1, POU3F1, and POU3F2 expression in clinical data. POU2F1 and POU3F1 were able to reverse the effect of SOX12 knockdown on thyroid cancer cells. Conclusion SOX12 affects the progression of thyroid cancer by regulating epithelial-mesenchymal transition and interacting with POU2F1 and POU3F1, which may be novel targets for thyroid cancer molecular therapy.

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“…They are matrix degradation enzymes (such as MMP), responsible for the degradation of the main constituents of basement membrane and extracellular matrix, facilitating the invasion of tumor cells and favoring the spread of cancer cells and metastases ( Nagase et al, 2006 ; Shuman Moss et al, 2012 ; Jabłońska-Trypuć et al, 2016 ). High MMP-2 and -9 levels were associated with esophageal carcinomas ( Koyama et al, 1990 ) and breast ( Alrehaili et al, 2020 ), oral ( Lin et al, 2004 ), bladder ( Fouad et al, 2019 ), skin ( Fundyler et al, 2004 ), larynx ( Liu et al, 2005 ) cancer. In this systematic review, only one in vivo study (10%) reported a decrease in the levels of MMP-2 and MMP-9 in liver cancer after treatment with carvacrol ( Subramaniyan et al, 2014 ), the majority 8.6% ( n = 6) were in vitro studies.…”

Section: Discussionmentioning

confidence: 99%

Antitumor Effects of Carvacrol and Thymol: A Systematic Review

et al. 2021

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Background: It is estimated that one in five people worldwide faces a diagnosis of a malignant neoplasm during their lifetime. Carvacrol and its isomer, thymol, are natural compounds that act against several diseases, including cancer. Thus, this systematic review aimed to examine and synthesize the knowledge on the antitumor effects of carvacrol and thymol.Methods: A systematic literature search was carried out in the PubMed, Web of Science, Scopus and Lilacs databases in April 2020 (updated in March 2021) based on the PRISMA 2020 guidelines. The following combination of health descriptors, MeSH terms and their synonyms were used: carvacrol, thymol, antitumor, antineoplastic, anticancer, cytotoxicity, apoptosis, cell proliferation, in vitro and in vivo. To assess the risk of bias in in vivo studies, the SYRCLE Risk of Bias tool was used, and for in vitro studies, a modified version was used.Results: A total of 1,170 records were identified, with 77 meeting the established criteria. The studies were published between 2003 and 2021, with 69 being in vitro and 10 in vivo. Forty-three used carvacrol, 19 thymol, and 15 studies tested both monoterpenes. It was attested that carvacrol and thymol induced apoptosis, cytotoxicity, cell cycle arrest, antimetastatic activity, and also displayed different antiproliferative effects and inhibition of signaling pathways (MAPKs and PI3K/AKT/mTOR).Conclusions: Carvacrol and thymol exhibited antitumor and antiproliferative activity through several signaling pathways. In vitro, carvacrol appears to be more potent than thymol. However, further in vivo studies with robust methodology are required to define a standard and safe dose, determine their toxic or side effects, and clarify its exact mechanisms of action.This systematic review was registered in the PROSPERO database (CRD42020176736) and the protocol is available at https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=176736.

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Clinical significance of plasma MMP‐2 and MMP‐9 levels as biomarkers for tumor expression in breast cancer patients in Egypt

Cited by 18 publications

References 24 publications

Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance

Clinical relevance of CERK and SPHK1 in breast cancer and their association with metastasis and drug resistance

SOX12 Promotes Thyroid Cancer Cell Proliferation and Invasion by Regulating the Expression of POU2F1 and POU3F1

Antitumor Effects of Carvacrol and Thymol: A Systematic Review

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