Clinical significance of plasma HDL subfractions (HDL2, HDL3) in patients with peripheral arterial disease (PAD) in the Greek population

Kalofoutis, A.; Papapanagiotou, Angeliki; Tzivras, Michalis

doi:10.1016/s0009-9120(98)00099-x

Cited by 6 publications

(7 citation statements)

References 28 publications

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“…In the Cardiovascular Health Study (2), the same increment of HDL-cholesterol was associated with a 15% lower prevalence of low AAI. These findings are consistent in that HDL-cholesterol levels were reduced in patients with peripheral arterial disease (27).…”

Section: Discussionsupporting

confidence: 84%

Ankle-Arm Blood Pressure Index and Cardiovascular Risk Factors in Elderly Japanese Men

et al. 2003

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Section: Discussionsupporting

confidence: 84%

Ankle-Arm Blood Pressure Index and Cardiovascular Risk Factors in Elderly Japanese Men

et al. 2003

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“…Due to statin treatment, plasma TC and LDL‐C levels were significantly decreased in all PAD patients compared to N subjects (Table 2). HDL‐C levels in all PAD patients were significantly lower than in N subjects, in good agreement with previous reports 19,20 . TG concentrations were increased in all PAD patients compared to N subjects.…”

Section: Resultssupporting

confidence: 92%

“…The data regarding HDL 2 and HDL 3 composition in PAD patients are scarce. It was reported that HDL 2 ‐C, HDL 3 ‐C, and their major protein, ApoAI, are significantly reduced in PAD patients compared to normal subjects 19,20 . PON1 activity plays an important role in conferring antioxidant properties to HDL 21,22 .…”

Section: Introductionmentioning

confidence: 99%

“…It was reported that HDL 2 -C, HDL 3 -C, and their major protein, ApoAI, are significantly reduced in PAD patients compared to normal subjects. 19,20 PON1 activity plays an important role in conferring antioxidant properties to HDL. 21,22 It was reported that the decrease of PON1 activity together with the presence of oxidized ApoAI in HDL from hyperlipidemic hamsters modifies the quality of HDL, rendering them dysfunctional.…”

Section: Introductionmentioning

confidence: 99%

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Clusterin, paraoxonase 1, and myeloperoxidase alterations induce high‐density lipoproteins dysfunction and contribute to peripheral artery disease; aggravation by type 2 diabetes mellitus

et al. 2021

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Peripheral artery disease (PAD) is an atherosclerotic disorder affecting arteries of the lower limbs, the major risk factors including dyslipidemia and diabetes mellitus (DM). We aimed to identify alterations of the proteins in high-density lipoproteins (HDL) associated with HDL dysfunction in PAD patients. HDL 2 and HDL 3 were isolated from plasma of PAD patients with/without DM (PAD-DM/PAD) and healthy subjects (N). Apolipoprotein AI (ApoAI), ApoAII, ApoCIII, clusterin (CLU), paraoxonase 1 (PON1), myeloperoxidase (MPO), and ceruloplasmin (CP) were measured in HDL 2 /HDL 3 and plasma. Oxidation and glycation of the analyzed proteins were assessed as malondialdehyde-protein adducts (MDA) and advanced glycation end-products (AGE), respectively. The anti-inflammatory effect of HDL 3 was estimated as its potential to reduce monocyte adhesion to tumor necrosis factor α-activated endothelial cells. We show that in PAD patients compared to N subjects: (i) HDL 2 presented increased levels of MDA-PON1, AGE-PON1, AGE-ApoAI, ApoAII, ApoCIII, and CP levels, and decreased PON1 levels; (ii) HDL 3 had increased levels of MDA-and AGE-CLU and -ApoAI, MDA-PON1, ApoCIII, CLU, MPO, CP, and reduced PON1 levels. All these alterations were exacerbated by DM. These changes were more pronounced in HDL 3 , which had reduced antiinflammatory potential in PAD and became pro-inflammatory in PAD-DM. In PAD patients' plasma, CLU levels and MPO specific activity increased, while PON1 specific activity decreased. In conclusion, HDL function

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“…High-density lipoprotein structure (as measured by subfraction concentration) is associated with CVD risk ( 15 , 16 ), and measurement of HDL function (as measured by HDL-C efflux capacity) has emerged as a robust marker of prevalent and incident CVD ( 17 ). The clinical significance and profile of HDL subfractions in patients with PAD are also not well understood with reports of both increased ( 18 ) and decreased ( 19 ) HDL3 levels in the setting of reduced HDL2 and HDL-C. The HDL subfractions, HDL2 and HDL3, are particles with unique size and density that may have distinct cholesterol efflux capacities ( 20 ), exhibit unique efflux responses to drug therapy ( 21 ), and have differential associations with CVD events ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

High-Density Lipoprotein Subfractions and Cholesterol Efflux Capacity Are Not Affected by Supervised Exercise but Are Associated with Baseline Interleukin-6 in Patients with Peripheral Artery Disease

Albaghdadi

Wang

Gao

et al. 2017

Front. Cardiovasc. Med.

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ObjectiveTo quantify the association between high-density lipoprotein (HDL) subfractions, efflux capacity, and inflammatory markers at baseline and the effect of supervised exercise on these HDL parameters in patients with peripheral artery disease (PAD).MethodsThe study to improve leg circulation (SILC) was a randomized trial of supervised treadmill exercise, leg resistance training, or control in individuals with PAD. In a post hoc cross-sectional analysis, we quantified the associations between baseline HDL subfraction concentrations (HDL2 and HDL3), HDL-C efflux capacity, and inflammatory markers [C-reactive protein (CRP) and interleukin-6 (IL-6)]. We then examined the effect of supervised exercise on changes in these lipoprotein parameters and inflammatory markers in 88 patients from SILC.ResultsBaseline HDL-C efflux capacity was associated with baseline concentrations of HDL2 (β = 0.008, p = 0.0106), HDL3 (β = 0.013, p < 0.0001), and IL-6 (β = −0.019, p = 0.03). Baseline HDL3 concentration was inversely associated with IL-6 concentration (β = −0.99, p = 0.008). Compared to control, changes in HDL2, HDL3, normalized HDL-C efflux capacity, CRP, or IL-6 were not significantly different at 6 months following the structured exercise intervention.ConclusionHDL efflux and HDL3 were inversely associated with IL-6 in PAD patients. Structured exercise was not associated with changes in HDL subfractions, HDL-C efflux capacity, CRP, and IL-6 in PAD patients. Our preliminary findings support the theory that inflammation may adversely affect HDL structure and function; however, further studies are needed to evaluate these findings.

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Clinical significance of plasma HDL subfractions (HDL2, HDL3) in patients with peripheral arterial disease (PAD) in the Greek population

Cited by 6 publications

References 28 publications

Ankle-Arm Blood Pressure Index and Cardiovascular Risk Factors in Elderly Japanese Men

Ankle-Arm Blood Pressure Index and Cardiovascular Risk Factors in Elderly Japanese Men

Clusterin, paraoxonase 1, and myeloperoxidase alterations induce high‐density lipoproteins dysfunction and contribute to peripheral artery disease; aggravation by type 2 diabetes mellitus

High-Density Lipoprotein Subfractions and Cholesterol Efflux Capacity Are Not Affected by Supervised Exercise but Are Associated with Baseline Interleukin-6 in Patients with Peripheral Artery Disease

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