Clinical significance of plasma fibrinogen and D-dimer in predicting the chemotherapy efficacy and prognosis for small cell lung cancer patients

Zhu, Liangjun; Li, J.; Chen, P.; Jiang, Qian; Tang, Xinping

doi:10.1007/s12094-015-1350-7

Cited by 57 publications

(65 citation statements)

References 34 publications

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“…These findings are in accordance with previous reports regarding other malignancies, such as lung, [35] esophageal, [36] gastric, [37] colorectal, [34] and ovarian [7] cancer. Most importantly, high plasma fibrinogen levels have been correlated with poor response to therapy, including response to trastuzumab treatment in HER2-positive breast cancer.…”

Section: Discussionsupporting

confidence: 93%

Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients

Zhang

Long²

2017

Medicine

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Hyperfibrinogenemia has been reported to be a predictor of poor prognosis in cancer patients, and in hepatocellular carcinoma (HCC) patients, survival remains uncertain and unpredictable. The aim of the present study was to evaluate the association between the level of plasma fibrinogen and overall survival in HCC patients.Overall, 308 patients with histologically proven HCC were included in our study. Univariate and multivariate analyses were performed to identify predictive risk factors for the rates of overall survival and tumor recurrence.Patients in the high-fibrinogen-level group were more likely to have advanced stage HCC, portal vein invasion, and tumors that were greater in number and larger in diameter than were patients in the low-fibrinogen-level group (all P < .05). The long-term overall survival rate of patients in the high-fibrinogen group was much lower than that of patients in the normal-fibrinogen group (P = .008), and similar outcomes were observed in the subgroup of patients who underwent radical therapies for HCC (P = .003). The results of the univariate and multivariate analyses indicated that high plasma fibrinogen remained independently associated with poorer overall survival. In addition, high plasma fibrinogen levels were associated with nonresponse to transarterial chemoembolization (TACE) (P < .001).Elevated plasma fibrinogen was independently associated with advanced HCC stage, poor prognosis, and nonresponse to TACE and may, therefore, serve as a valuable clinical biomarker for predicting prognosis in HCC patients.

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Section: Discussionsupporting

confidence: 93%

Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients

Zhang

Long²

2017

Medicine

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“…For instance, D‐dimer levels can be utilized as a predictor of immediate mortality in patients with in‐hospital cardiac arrest . An increasing body of evidence suggests the existence of a relationship between activation of coagulation and tumor angiogenesis, progression, and metastatic spread . Fibrinogen and D‐dimer levels are easily obtainable tests commonly ordered for inpatients.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have reported that plasma fibrinogen and/or D‐dimer levels can predict poor prognosis in several types of malignancies including ovarian, breast, colorectal, lung, gastric, and pancreatic cancer . In lung cancer, plasma fibrinogen and D‐dimer levels have been shown to be associated with tumor pathological stage, response to therapy, and survival . In epithelial cell origin ovarian cancer, pretreatment plasma D‐dimer and fibrinogen have been shown to be able to predict disease progression and surgical outcome as well as to help identify and treat high‐risk populations .…”

Section: Introductionmentioning

confidence: 99%

Fibrinogen and D‐dimer levels elevate in advanced hepatocellular carcinoma: High pretreatment fibrinogen levels predict poor outcomes

Liu

Guo

Gao

et al. 2017

Hepatology Research

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“…A number of studies have shown that plasma fibrinogen level is upregulated in various cancers and may account for progression and metastasis [5–8]. However, there are conflicting findings on the role of plasma fibrinogen and survival outcomes in RCC.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis

Tian

Hong

Jing

et al. 2017

BioMed Research International

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Background. Although numerous studies have shown that plasma fibrinogen is linked to renal cell carcinoma (RCC) risk, the consistency and magnitude of the effect of plasma fibrinogen are unclear. The aim of the study was to explore the association between plasma fibrinogen and RCC prognosis. Methods. An electronic search of Embase, PubMed/MEDLINE, and the Cochrane databases was performed to identify relevant studies published prior to June 1, 2016. Results. A total of 3744 patients with RCC from 7 published studies were included in the meta-analysis. The prognostic and clinical relevance of plasma fibrinogen are evaluated in RCC patients. Statistical significance of the combined hazard ratio (HR) was detected for overall survival, cancer-specific survival, and disease-free survival. Our pooled results showed that elevated plasma fibrinogen was significantly associated with clinical stage and Fuhrman grading. The level of plasma fibrinogen was not found to be associated with tumor type and gender. Conclusions. Elevated plasma fibrinogen is a strong indicator of poorer prognosis of patients with RCC, whereas the plasma fibrinogen is not significantly associated with tumor type. Therefore, plasma fibrinogen could be used in patients with RCC for risk stratification and decision providing a proper therapeutic strategy.

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Clinical significance of plasma fibrinogen and D-dimer in predicting the chemotherapy efficacy and prognosis for small cell lung cancer patients

Abstract: Fibrinogen and D-dimer levels after two cycles of chemotherapy are predictors for response on chemotherapy and prognosis in SCLC patients.

Cited by 57 publications

References 34 publications

Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients

Elevated serum plasma fibrinogen is associated with advanced tumor stage and poor survival in hepatocellular carcinoma patients

Fibrinogen and D‐dimer levels elevate in advanced hepatocellular carcinoma: High pretreatment fibrinogen levels predict poor outcomes

Clinical and Prognostic Effect of Plasma Fibrinogen in Renal Cell Carcinoma: A Meta-Analysis

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