Clinical significance of osteopontin expression in T1 and T2 tongue cancers

Background:Early detection of oral squamous cell carcinoma (OSCC) remains one of the most efficient ways to ensure patient survival and improved quality of life. Although specific biomarkers related to OSCC have been investigated, a useful biomarker that assesses the transition potential of potentially malignant lesion to OSCC remains to be found. Osteopontin (OPN) has been recognized as an important factor in tumorigenesis and their expression in OSCC have been investigated earlier. In the present study, evaluation of OPN expression in premalignant and malignant lesions has been carried out to assess their possible role as a biomarker in the early diagnosis and prognosis of OSCC.Objectives:The objective of this study is to evaluate the role of OPN as a biomarker in the diagnosis and prognosis of OSCC.Materials and Methods:The study group consisted of archival paraffin-embedded blocks of ten cases each of varying grades of OSCC, oral epithelial dysplasias and epithelial hyperplasias. Sections were subjected to immunohistochemical staining for the biomarker OPN.Results:A positive OPN expression was noticed in epithelial dysplasias and SCC arising from the oral epithelium. A progressive increase in the intensity of staining was seen with increasing grades of dysplasias and a decrease in OPN expression with an increase in grades was observed in OSCC.Conclusion:The expression of OPN in full thickness of epithelium in severe dysplasias, carcinoma in situ, and in the superficial epithelium of OSCC suggest the possibility of considering OPN expression in full epithelial thickness in dysplasias as an indicator for malignant transformation.

show abstract

“…[3] However, our findings were similar to many of the previous studies which showed negative OPN expression in oral hyperplasias. [910]…”

Section: Discussionmentioning

confidence: 99%

Immunolocalization of osteopontin in dysplasias and squamous cell carcinomas arising from oral epithelium

Aravind

Janardhanan

Rakesh

et al. 2017

J Oral Maxillofac Pathol

View full text Add to dashboard Cite

show abstract

“…It can also be induced by VEGF and is involved in vessel angiogenesis and endothelial cell survival [127–129]. Matsuzaki et al [130] failed to demonstrate a correlation between OPN expression and lymphatic metastases and survival in T1-4 tongue cancer, but OPN expression has also been studied in T1-2 tongue cancer using a different means of immunohistochemical evaluation [131]. Thirty out of 94 patients (31.9%) expressed OPN and this significantly correlated with a more advanced T stage (T2 versus T1) ( P = .004), positive lymph nodes ( P < .001), the presence of tumor necrosis ( P = .016), and greater tumour thickness ( P < .001).…”

Section: Osteopontinmentioning

confidence: 99%

Biomolecular Markers in Cancer of the Tongue

Ferrari

Codecà

Fiore

et al. 2009

Journal of Oncology

View full text Add to dashboard Cite

The incidence of tongue cancer is increasing worldwide, and its aggressiveness remains high regardless of treatment. Genetic changes and the expression of abnormal proteins have been frequently reported in the case of head and neck cancers, but the little information that has been published concerning tongue tumours is often contradictory. This review will concentrate on the immunohistochemical expression of biomolecular markers and their relationships with clinical behaviour and prognosis. Most of these proteins are associated with nodal stage, tumour progression and metastases, but there is still controversy concerning their impact on disease-free and overall survival, and treatment response. More extensive clinical studies are needed to identify the patterns of molecular alterations and the most reliable predictors in order to develop tailored anti-tumour strategies based on the targeting of hypoxia markers, vascular and lymphangiogenic factors, epidermal growth factor receptors, intracytoplasmatic signalling and apoptosis.

show abstract

“…Petrik et al, suggested plasma OPN is an independent prognostic marker for head & neck cancer [15]. Two studies have been carried so far, to evaluate the expression of OPN in human OSCC [16,17]. To the best of knowledge, this is the first study to analyse the expression of OPN in OSCC and patient matched tumour free surgical margins of OSCC.…”

Section: Methodsmentioning

confidence: 99%

Expression of Osteopontin in Oral Squamous Cell Carcinoma and its Surgical Margins-An Immunohistochemical Study

Subramani

Narasimhan

Thiyagarajan

et al. 2015

JCDR

View full text Add to dashboard Cite

Clinical significance of osteopontin expression in T1 and T2 tongue cancers

Abstract: Overexpression of OPN in the tumors implicated a more aggressive tumor behavior and was an important factor for survival. In addition, there might be relationship between OPN and CD105 expressions in angiogenesis.

Cited by 24 publications

References 58 publications

Immunolocalization of osteopontin in dysplasias and squamous cell carcinomas arising from oral epithelium

Immunolocalization of osteopontin in dysplasias and squamous cell carcinomas arising from oral epithelium

Biomolecular Markers in Cancer of the Tongue

Expression of Osteopontin in Oral Squamous Cell Carcinoma and its Surgical Margins-An Immunohistochemical Study

Contact Info

Product

Resources

About