Clinical Significance of Nontuberculous Mycobacteria Isolated From Respiratory Specimens in Korea

Koh, Won‐Jung; Kwon, O Jung; Jeon, Kyeongman; Kim, Tae Sung; Lee, Kyung Soo; Park, Young Kil; Bai, Gill Han

doi:10.1378/chest.129.2.341

Cited by 252 publications

(217 citation statements)

References 31 publications

(37 reference statements)

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“…Most isolates were MAC members (9/13, 69%), a predominance also noted in previous studies in the United States, Europe, and west Asian countries (25%) (1,8), and South Korea (48%) (9 isolates in the random sample. Previous North American studies have suggested that M. intracellulare is the more common pulmonary pathogen within the MAC (1).…”

Section: Discussionsupporting

confidence: 82%

Clinical Relevance of Nontuberculous Mycobacteria, Oman

Al-Mahruqi¹,

Ingen²,

Al-Busaidy³

et al. 2009

Emerg. Infect. Dis.

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Little is known about the clinical relevance of nontuberculous mycobacteria (NTM) in the Arabian Peninsula. We assessed the prevalence and studied a random sample of isolates at a reference laboratory in Muscat, Oman. NTM cause disease in this region, and their prevalence has increased.N ontuberculous mycobacteria (NTM) are common inhabitants of the environment and have been cultured from water, soil, and animal sources worldwide. NTM are opportunistic pathogens, mostly affecting patients with preexisting pulmonary disease such as chronic obstructive pulmonary disease or tuberculosis (TB), or those with systemic impairment of immunity. The latter group includes those with HIV infection, those using immunosuppressive drugs, and those with leukemia (1).Because NTM are common in the environment and resistant to commonly used disinfectants, they can be present in nonsterile patient material such as sputum and contaminated medical equipment (bronchoscope washers or samples in the laboratory) and consequently cause pseudoinfection (1,2). To distinguish pseudoinfections from NTM disease and establish the clinical relevance of isolated NTM, the American Thoracic Society (ATS) has published diagnostic criteria (1).Studies on the clinical relevance of NTM have traditionally been restricted to western countries, where the incidence of TB is relatively low. More recently, research has been initiated in African and East Asian countries (1-5). There have been no recent reports on isolation and clinical relevance of NTM on the Arabian Peninsula. We analyzed a random sample of NTM isolated from clinical samples in Oman by using molecular techniques. Their clinical relevance was retrospectively analyzed by applying the updated ATS diagnostic criteria for NTM disease (1). The StudyPrevalence of NTM at the Central Public Health Laboratory (CPHL), the national TB reference laboratory of the Ministry of Health in Muscat, Oman, was assessed by using a laboratory database. The CPHL Institutional Review Board reviewed and approved this study. The CPHL received 5,488 samples submitted for Mycobacterium spp. culture during 2006-2007. Samples were subcultured in Lowenstein-Jensen medium and automated Mycobacterial Growth Indicator Tubes (MGIT960; Becton Dickinson, Franklin Lakes, NJ, USA) and incubated at 36°C. A total of 491 (9%) samples yielded positive cultures. M. tuberculosis complex bacteria were isolated from 445 (91%) samples, and NTM were isolated from 46 samples (9%). Most NTM were cultured from respiratory samples (sputum, n = 36, 78%; bronchial lavage, n = 2, 4%); the remainder were from lymph nodes (n = 3, 6%), urine (n = 2, 4%), or other sources (n = 3, 6%). The percentage of NTM increased from 7.6% (18/235) in 2006 to 10.9% (28/256) in 2007.Thirteen samples were randomly selected from all NTM isolated at CPHL during January 2006-September 2007. Selected NTM were subjected to molecular identification at the Dutch National Mycobacteria Reference Laboratory (National Institute for Public Health and the Environment, Bilthoven, ...

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Section: Discussionsupporting

confidence: 82%

Clinical Relevance of Nontuberculous Mycobacteria, Oman

Al-Mahruqi¹,

Ingen²,

Al-Busaidy³

et al. 2009

Emerg. Infect. Dis.

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“…3,23 Also, in a study from Korea, MABSC was among the most frequently isolated NTM species with considerably higher clinical relevance compared to our results. 24 The exact reason for such apparent regional differences remains unknown. However, the limited significance of M. kansasii in our study may result from its infrequent isolation and the fact that many patients had a concomitant disease (i.e.…”

Section: Clinical Relevance Differs By Ntm Speciesmentioning

confidence: 99%

Microbiological criteria in non-tuberculous mycobacteria pulmonary disease: a tool for diagnosis and epidemiology

Janković¹,

Sabol²,

Žmak³

et al. 2016

int j tuberc lung dis

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“…24 Koh ve ark., MAC'ye bağlı akciğer hastalığında nodüler bronşektazi formunun %52, üst lob kavite formunun ise %42 oranında tespit edildiğini bildirmiştir. 25 Bizim çalışmamızda hastaların radyolojik incelemesinde 27 (%64,3) hastada bilateral lezyonlar ve göğüs radyografisinde en sık olarak kavite (%64,3), segmenter veya subsegmenter homojen opasiteler (%57,8) ATS ve BTS, tedaviye yanıtsız olan veya nük-seden olgularda ilaç duyarlılık testinin yapılmasını önermektedir. 10,15 Rutin duyarlılık testleri, MAC izolatlarına yönelik sadece klaritromisin için, M. kansasii izolatlarına yönelik sadece rifampin için, HÜM'lere yönelik ise amikasin, imipenem, doksisilin, kinolonlar, trimetoprim-sülfometoksazol, sefoksitin, klaritromisin, linezolit ve tobramisin için önerilmektedir.…”

Section: Discussionunclassified

Non-Tuberculous Mycobacterial Lung Diseases: Retrospective Analysis of 42 Cases

Kılıçaslan¹,

Kuyucu²,

Babalik³

et al. 2013

Turkiye Klinikleri J Med Sci

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Hsp65PCRREA. Data on therapeutic management, radiological and bacteriological findings, co-morbidities and treatment outcomes were obtained from medical records, direct phone calls to patients and tuberculosis dispensaries. R Re e--s su ul lt ts s: : The most frequently identified NTM types were Mycobacterium abscessus, Mycobacterium avium and Mycobacterium kansasii [n=14 (33.3%), 9 (21.4%) and 8 (19.0%), respectively]. Co-morbidities were identified in 20 (47.6%) [respiratory in 11 (26.2%) and non-respiratory in 9 (21.4%)] patients. Chest x-ray revealed cavity in 27 (63.4%), segmental or subsegmental homogenous opacities in 23 (57.8%) and focal acinar, alveolar, micronodular opacities in 23 (57.8%) patients; 27 (64.3%) cases had bilateral involvement. Drug sensitivity testing for first-line drugs performed in 30 (71.4%) patients revealed isoniazide+rifampicin resistance in 18 (60.0%) patients, while drug sensitivity testing for second-line drugs was performed in 16 (38.1%) patients. Treatment outcome was cure in 26 (61.9%) patients, treatment failure in 2 (4.8%), death in 3 (7.1%), ongoing treatment in 5 (11.9%) and follow-up without treatment in 5 (11.9%) patients, while 1 (2.4%) patient stopped treatment. C Co on nc cl lu us si io on n: : Identification of the mycobacterium type in patients with pulmonary TDM infection is essential for correct diagnosis and best treatment planning in addition to obtaining real-life epidemiologic data in Turkey. Lack of identification of the mycobacterium delays the diagnosis and causes resistance development in TDM patients. In patients with TDM infection, treatment should be planned based on both clinical and bacteriological findings.

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Clinical Significance of Nontuberculous Mycobacteria Isolated From Respiratory Specimens in Korea

Cited by 252 publications

References 31 publications

Clinical Relevance of Nontuberculous Mycobacteria, Oman

Clinical Relevance of Nontuberculous Mycobacteria, Oman

Microbiological criteria in non-tuberculous mycobacteria pulmonary disease: a tool for diagnosis and epidemiology

Non-Tuberculous Mycobacterial Lung Diseases: Retrospective Analysis of 42 Cases

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