Clinical significance of non-invasive skin autofluorescence measurement in patients with diabetes: a systematic review and meta-analysis

Hosseini, Mahboobeh Sadat; Razavi, Zahra; Ehsani, Amir Houshang; Firooz, Alireza; Afazeli, Siamack

doi:10.1016/j.eclinm.2021.101194

Cited by 13 publications

(10 citation statements)

References 56 publications

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“…Taken together, a multicentre study with 280 T2D and 280 healthy control subjects in China, con rmed that the SAF continues to be a reliable tool of AGEs accumulation which is related to long-term complications of diabetes [33], particularly in the cardiovascular eld [34]. AGEs have also been related as biomarkers for different complications in T2D patients [35], different than the skin ones intended in this study. It also supported the fact that SAF shows differences in males than females and that gender, ethnicity and race may play a major role in these variations.…”

Section: Discussionmentioning

confidence: 54%

Potential Association of Type-2 Diabetes (T2D) and Advanced Glycation End Products (AGEs) measured by Skin Autofluorescence in Chinese Population

Ouyang

Ni²,

Quéral

et al. 2022

Preprint

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Background: Type-2 diabetes (T2D) has been associated with increased endogenous formation of advanced glycation end products (AGEs). Their accumulation in different tissues including articular collagen, skeletal and smooth vascular muscles, or glomerular basement membranes in T2D patients have been implicated. Objective: To assess the potential association of T2D in skin ageing associated with AGEs in Chinese population.Methods: A multicentre study was conducted in Chinese population of 560 subjects aged between 50 and 70 years who were evenly assigned in two groups of 280 each, paired by health status (healthy/diabetic), gender, and age group well balanced for hormonal replacement therapy/menopausal status, body mass index (BMI), smoking status and skin characteristics. Skin conditions were examined by a dermatologist and skin autofluorescence (SAF) a marker of AGEs measured by a validated non-invasive in vivo measurement technique.Results: The results from this study confirmed the association of diabetes and skin ageing as increased AGEs accumulation were measured using SAF and contributed evidence on gender and ethnic origin on AGEs variations. This study opens the path of further investigation into the identification of significant effects of diabetes on major facial skin complexion parameters.

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Section: Discussionmentioning

confidence: 54%

Potential Association of Type-2 Diabetes (T2D) and Advanced Glycation End Products (AGEs) measured by Skin Autofluorescence in Chinese Population

Ouyang

Ni²,

Quéral

et al. 2022

Preprint

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“…[ 56 ] Moreover, we discovered a connection between HbA1c and SAF levels in our earlier research. [ 3 ] The absence of relationship between HbA1c and AGEs in some of the studies considered may be because of the shorter HbA1c turnover time compared to SAF, the different approaches to managing the hyperglycemic condition, and the subsequent oxidative stress experienced by people. [ 20 ] Correspondingly, some studies including review articles and meta-analyses have declared the validity of AGE measurement by SAF as a noninvasive tool to expect diabetic vascular complications.…”

Section: Discussionmentioning

confidence: 99%

“…It is estimated to be one of the top 10 causes of death in adults. [ 1 2 3 ] Excess tissue glucose reacts with macromolecules such as nucleic acids, lipids, and proteins nonenzymatically, as a consequence, heterogeneous advanced glycation end products (AGE) would be produced. Thus, such irreversible alteration in macromolecule structures will impair their function.…”

Section: Introductionmentioning

confidence: 99%

“…In our previous meta-analysis study, we obtained that higher SAF measurements were significantly associated with several diabetic complications, such as retinopathy, nephropathy, and neuropathy. [ 3 ] Similarly, a recent meta-analysis study demonstrated that SAF as a novel technology can successfully evaluate the risk of diabetic foot ulcers. [ 6 ] In addition, in a study, the authors suggested SAF measurement as a noninvasive technology for the detection of DM and individuals with impaired fasting glucose.…”

Section: Introductionmentioning

confidence: 99%

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Is skin autofluorescence a novel non-invasive marker in diabetes? A systematic review and meta-analysis of case–control studies

Sadeghi,

Hosseini,

Razavi

et al. 2023

J Res Med Sci

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Background: The advanced glycation end product (AGE) is produced from the nonenzymatic reaction between glucose and macromolecules by aging. Accumulation of AGE causes functional and structural changes in body proteins that lead to impairment of tissue protein functions. We aimed to validate AGE measurement by skin autofluorescence (SAF) in diabetes mellitus (DM) compared to the nondiabetes population. Materials and Methods: We searched the PubMed, Cochrane, and Scopus databases from their inception till September 18, 2022, for casecontrol studies measuring AGE by SAF. Nonhuman studies, as well as review articles, study proposals, editorials, case reports, or congress posters, were excluded. We used a random effects model to assess the standard mean difference (MD) of age, body mass index (BMI), HbA1c, and SAF between diabetes and nondiabetes individuals. Results: Higher SAF in DM patients indicated more accumulation of AGE compared with the nondiabetic population. Furthermore, HbA1c was considerably higher in DM patients. The MD of age, male gender, and BMI were significantly different between the DM individuals, compared with nondiabetic subjects, which can lead to altered SAF level and AGE production. There was a remarkable heterogeneity between diabetes and nondiabetes when measuring age, gender, and BMI, as well as HbA1c and SAF level. Conclusion: This study could not confirm the validity of SAF as a surrogate marker in diabetes patients. Interestingly, metabolic load and high BMI can increase SAF, considerably. Altogether, SAF could be helpful in the future as a marker for metabolic syndrome or diabetes.

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“…Additionally, as the number of complications increases, the SAF value also increases. Hosseini et al [ 45 ], in a systematic review and meta-analysis, suggested that SAF levels could be a predictor of chronic micro and macrovascular complications in DM.…”

Section: Saf and Diabetic Microvascular Complicationsmentioning

confidence: 99%

Advanced Glycations End Products in the Skin as Biomarkers of Cardiovascular Risk in Type 2 Diabetes

Planas

Simó‐Servat

Hernández

et al. 2022

IJMS

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The incidence and prevalence of diabetes are increasing worldwide, and cardiovascular disease (CVD) is the leading cause of death among subjects with type 2 diabetes (T2D). The assessment and stratification of cardiovascular risk in subjects with T2D is a challenge. Advanced glycation end products are heterogeneous molecules produced by non-enzymatic glycation of proteins, lipids, or nucleic acids. Accumulation of advanced glycation end products is increased in subjects with T2D and is considered to be one of the major pathogenic mechanism in developing complications in diabetes. Skin AGEs could be assessed by skin autofluorescence. This method has been validated and related to the presence of micro and macroangiopathy in individuals with type 2 diabetes. In this context, the aim of this review is to critically summarize current knowledge and scientific evidence on the relationship between skin AGEs and CVD in subjects with type 2 diabetes, with a brief reference to other diabetes-related complications.

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Clinical significance of non-invasive skin autofluorescence measurement in patients with diabetes: a systematic review and meta-analysis

Cited by 13 publications

References 56 publications

Potential Association of Type-2 Diabetes (T2D) and Advanced Glycation End Products (AGEs) measured by Skin Autofluorescence in Chinese Population

Potential Association of Type-2 Diabetes (T2D) and Advanced Glycation End Products (AGEs) measured by Skin Autofluorescence in Chinese Population

Is skin autofluorescence a novel non-invasive marker in diabetes? A systematic review and meta-analysis of case–control studies

Advanced Glycations End Products in the Skin as Biomarkers of Cardiovascular Risk in Type 2 Diabetes

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