Clinical Significance of N-Terminal Fragment of Natriuretic Peptide in Patients With Systemic Lupus Erythematosus Who Do Not Receive Pathogenetic Therapy

Panafidina, T.; Сохова, М. А.; Попкова, Т. В.; Новикова, Д. С.; Александрова, Е. Н.; Корсакова, Ю. О.; Волков, А. В.

doi:10.14412/1995-4484-2017-376-381

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…В приведенных исследованиях концентрация BNP/NTproBNP определялась только у больных СКВ, получающих патогенетическую терапию. Ранее нами была опубликова-на работа, целью которой являлась оценка концентрации NT-proBNP у пациентов с СКВ, не имеющих КВЗ, и до на-значения иммуносупрессивной терапии [26]. Концентра-ция NT-proBNP у пациентов с СКВ была значительно вы-ше, чем в группе контроля: соответственно 161 и 55 пг/мл (р<0,001), повышенный уровень NT-proBNP (>125 пг/мл) обнаружен у 64% больных СКВ.…”

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Heart Failure in Systemic Lupus Erythematosus: Risk Factors and Diagnostic Features

Panafidina¹,

Popkova²

2018

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With increased survival in patients with systemic lupus erythematosus (SLE), cardiovascular diseases have become the main causes of death. Heart failure (HF) is the final stage of the cardiovascular continuum; decompensation of this condition commonly results in death. Studies of HF, its frequency, risk factors, and diagnostic features in patients with SLE are extremely few. The paper details data on the definition, frequency, current classification, and the algorithm for the diagnosis of HF and comparatively analyzes the risk factors of the latter in the general population and among patients with SLE. HF diagnostic problems in this patient category and possible ways of their resolution are discussed.

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Heart Failure in Systemic Lupus Erythematosus: Risk Factors and Diagnostic Features

Panafidina¹,

Popkova²

2018

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Cardiovascular manifestations of systemic lupus erythematosus: the significance of heart failure

Karateev¹

2023

Naučno-praktičeskaâ revmatologiâ

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The involvement of the cardiovascular system is a typical manifestation of systemic lupus erythematosus (SLE), which determines the high level of mortality and disability of patients. A serious clinical problem is the development of heart failure (HF), which frequency in SLE is 3–4 times more than in the population. The development of this pathology is a complex process that occurs under the influence of systemic autoimmune inflammation and associated with heart damage (pericarditis, myocarditis, endocarditis, сcoronary artery disease, myocardial infarction), disorders of the cardiac conduction system (various arrhythmias), atherosclerosis, arterial hypertension, pulmonary hypertension, thrombosis against connected with bleeding disorders (especially associated with antiphospholipid syndrome), traditional risk factors, as well as the negative effect of anti-rheumatic therapy. Mostly HF in SLE occurs in a subclinical form with a preserved ejection fraction, and is detected using instrumental methods in more than 60% of patients. The management of patients with SLE and HF requires early diagnosis of this pathology, to do this, various diagnostic methods are used (particularly, echocardiography with speckle tracking imaging technique) and the identification of biomarkers such as NT-proBNP. HF therapy in SLE patients is based on the maximal reduction o f the activity of the disease due to rational pathogenetic therapy, also the control of traditional risk factors – antihypertensive therapy, the use of statins and the prevention of arterial and venous thrombosis.

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Clinical Significance of N-Terminal Fragment of Natriuretic Peptide in Patients With Systemic Lupus Erythematosus Who Do Not Receive Pathogenetic Therapy

Abstract: О р и г и н а л ь н ы е и с с л е д о в а н и я ФГБНУ «Научноисследовательский институт ревматологии им. В.А. Насоновой»,

Cited by 2 publications

References 18 publications

Heart Failure in Systemic Lupus Erythematosus: Risk Factors and Diagnostic Features

Heart Failure in Systemic Lupus Erythematosus: Risk Factors and Diagnostic Features

Cardiovascular manifestations of systemic lupus erythematosus: the significance of heart failure

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