Clinical significance of micrometastases in lymph nodes from laryngeal squamous cell carcinoma

Xu, Yunhua; Fei, Mengjia; Wang, Jiadong; Zheng, Lan; Chen, Yiming; Liu, Qiang

doi:10.1016/j.amjoto.2011.10.012

Cited by 10 publications

(14 citation statements)

References 18 publications

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“…Nieuwenhuis et al found that the survival of patients with cN0 but with one or more micrometastases (detected by molecular analysis) was worse compared to patients without micrometastases (10). Similar results were published by Xu et al (18)(19) and Yamazaki et al (21). Presence of unrecognized micrometastases or ones left in situ can also explain regional tumor recurrence in patients with N0 stage or in patients with N+ stage after selective neck dissection.…”

Section: Discussionsupporting

confidence: 73%

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Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

Čelakovský

Kalfeřt

Smatanová

et al. 2015

Acta Med. (Hradec Kralove, Czech Repub.)

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Summary:Background: The goal of this prospective study was to determine the frequency of micrometastases in patients with squamous cell carcinoma (SCC) of the oral cavity, pharynx and larynx in whom elective neck dissection was indicated (cN0). Patients and Methods: A total of 12 patients (10 males and 2 females) were enrolled in the study. The age ranged 42-73 years (median 62 years). Elective neck dissection was performed in all patients (8 ipsilateral, 4 bilateral) and a total of 256 lymph nodes were removed and sent for microscopic examination. Results: The presence of tumor cells in cervical lymph nodes was found in 5/12 (42%) patients. Micrometastases of SCC were found in two patients and isolated tumor cells (ITC) in two other patients. In the remaining one patient with oropharyngeal SCC, a micrometastasis of papillary thyroid carcinoma (PTC) was detected. Positive lymph nodes were localized in level II in three patients with SCC of larynx, hypopharynx and tongue base, respectively, in level I in one patient with SCC of oral tongue and in level III in one patient with PTC. Conclusion: Our results indicate that SCC of head and neck has a high potential for creating micrometastases which frequency is higher compared to clinically detected macrometastases. Therefore, elective neck dissection or radiotherapy of the neck should be considered in patients with high risk of occult metastases or micrometastases.

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Section: Discussionsupporting

confidence: 73%

“…On the other hand, the presence of micrometastases is clinically significant (8,(18)(19)(20). Nieuwenhuis et al found that the survival of patients with cN0 but with one or more micrometastases (detected by molecular analysis) was worse compared to patients without micrometastases (10).…”

Section: Discussionmentioning

confidence: 99%

Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

Čelakovský

Kalfeřt

Smatanová

et al. 2015

Acta Med. (Hradec Kralove, Czech Repub.)

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“…Immunohistochemistry and polymerase chain reaction for pankeratin (AE1/AE3) as well as CK19/20 are very helpful in detecting occult micrometastasis. 1,[9][10][11][12][13][14] Detection of mutated KRAS has been found to be useful in carcinoma of the breast. 1,15 The technique of triple-leveling 16,17 has been used for various tumors.…”

Section: Lymph Node Metastasismentioning

confidence: 99%

Morphological Assessment of Lymph Nodes Draining Carcinoma

Saldanha¹

2016

MGM Journal of Medical Sciences

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Lymph nodes draining tumors are considered anatomic barriers to tumor spread. The involvement of lymph nodes by metastatic spread of tumors signifies the start of a new phase in the progress of a cancer. It indicates that through a succession of molecular changes, the cancer cells have acquired phenotypes that enable them to invade, colonize, and disseminate. Lymph node status is one of the most important indicators of clinical outcome. Lymph nodes are also the site where specific immune interactions between tumor antigens and lymphoid cells take place. Enlargement of nodes may be caused by spread of cancer cells or due to reactive hyperplasia of lymph nodes in response to tumor-associated antigens (TAA). The various lymphoid cell populations react in various ways, giving rise to different morphologic patterns. Only a few studies have investigated possible correlations between the patterns of lymph node reactivity and prognosis in malignant tumors. Histological analysis of the patterns in the regional lymph nodes draining the tumor could elucidate the immunological host-tumor relationship and provide additional information on patient survival. Increasing size of the tumor, higher grade, and stage are likely to show decreased number of reactive lymph nodes. More extensive studies on lymph node immune response patterns will be helpful in providing information on patient prognosis.

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“…Cytokeratin is a basic component of the cellular structure of normal epithelial cells and epithelial cancer cells, and immunohistochemical staining of lymph nodes can facilitate the detection of a single cancer cell or small clusters of cancer cells that could be readily missed by routine histological examinations. In recent studies, 5% to 38% of patients with head and neck SCC were reported to harbor occult metastases not identified by routine histopathology, which were instead detected by immunohistochemistry or molecular biology techniques, and by reverse transcriptase polymerase chain reaction …”

Section: Discussionmentioning

confidence: 99%

“…In recent studies, 5% to 38% of patients with head and neck SCC were reported to harbor occult metastases not identified by routine histopathology, which were instead detected by immunohistochemistry or molecular biology techniques, and by reverse transcriptase polymerase chain reaction. [17][18][19][20] In addition to the TNM stage, tumor depth is an important factor in evaluating the prognosis of patients with head and neck cancer. 21,22 In this study, the correlation between positive micrometastasis findings and the depth of invasion (p < .001) and primary tumor size (p 5 .034) were investigated.…”

Section: Discussionmentioning

confidence: 99%

Prognostic impact of lymph node micrometastasis in oral and oropharyngeal squamous cell carcinomas

et al. 2015

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Clinical significance of micrometastases in lymph nodes from laryngeal squamous cell carcinoma

Cited by 10 publications

References 18 publications

Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

Detection of Cervical Lymph Node Micrometastases in Patients with Squamous Cell Carcinoma of the Oral Cavity, Pharynx and Larynx

Morphological Assessment of Lymph Nodes Draining Carcinoma

Prognostic impact of lymph node micrometastasis in oral and oropharyngeal squamous cell carcinomas

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